KUAILU LIN^1,2, QIANYU GU², XIXI LAI^2,3,*

BIOCELL, Vol.47, No.12, pp. 2681-2696, 2023, DOI:10.32604/biocell.2023.043298

Abstract Objectives: Triple-negative breast cancer (TNBC) poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior. Methods: We analyzed clinical information and mRNA expression data from 162 TNBC patients in TCGA-BRCA and 320 patients in METABRIC-BRCA. Utilizing weighted gene coexpression network analysis, we pinpointed 34 TNBC immune genes linked to survival. The least absolute shrinkage and selection operator Cox regression method identified key TNBC immune candidates for prognosis prediction. We calculated chemotherapy sensitivity scores using the “pRRophetic” package in R software and assessed immunotherapy response using the Tumor Immune Dysfunction and… More >

Alan E. Kazdin^*

International Journal of Mental Health Promotion, Vol.24, No.4, pp. 457-473, 2022, DOI:10.32604/ijmhp.2022.022522

Abstract Advances in precision treatment promise to greatly improve the extent to which therapies for mental disorders are better matched to patient characteristics. At the same, we need to ensure that more readily disseminable and available nonprecison treatments are further developed as well. These treatments refer to standardized interventions that do not have to be individualized and are more readily available. Impetus for this call stems from the treatment gap, namely, the huge difference in the proportion of individuals who are in need of mental health services and who actually receive any form of treatment. The prevalence rates for mental disorders… More >