Fen Liu*†, Shaojun Liu*, Feiyan Ai*†, Decai Zhang*†, Zhiming Xiao*, Xinmin Nie‡, Yunfeng Fu§
Oncology Research, Vol.28, No.5, pp. 553-557, 2020, DOI:10.3727/096504020X16032056440094
Abstract Colorectal cancer (CRC) is one of the most common malignancies in the world, with a high incidence and a
high mortality. However, the pathogenesis of CRC carcinogenesis is still unexplored. In this study, we investigated the role of miR-107 in the regulation of CRC cell proliferation and apoptosis. First, the expression of
miR-107 was observed to be aberrantly increased in human CRC tumor tissues and cell lines when compared to
the colonic control tissues and colon epithelial cells. Further study showed that the proliferative and apoptotic
capacities of human CRC SW480 and LoVo cells were aberrantly regulated by miR-107. The… More >
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