T. Edwin Ponraj^1,*, J. Charles²

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 1189-1203, 2023, DOI:10.32604/iasc.2023.033383

Abstract The mutation is a critical element in determining the proteins’ stability, becoming a core element in portraying the effects of a drug in the pharmaceutical industry. Doing wet laboratory tests to provide a better perspective on protein mutations is expensive and time-intensive since there are so many potential mutations, computational approaches that can reliably anticipate the consequences of amino acid mutations are critical. This work presents a robust methodology to analyze and identify the effects of mutation on a single protein structure. Initially, the context in a collection of words is determined using a knowledge graph for feature selection purposes.… More >

DIEGO MASONE^1,2,*

BIOCELL, Vol.47, No.1, pp. 1-14, 2023, DOI:10.32604/biocell.2023.024146

Abstract The inflexible concept of membrane curvature as an independent property of lipid structures is today obsolete. Lipid bilayers behave as many-body entities with emergent properties that depend on their interactions with the environment. In particular, proteins exert crucial actions on lipid molecules that ultimately condition the collective properties of the membranes. In this review, the potential of enhanced molecular dynamics to address cell-biology problems is discussed. The cases of membrane deformation, membrane fusion, and the fusion pore are analyzed from the perspective of the dimensionality reduction by collective variables. Coupled lipid-protein interactions as fundamental determinants of large membrane remodeling events… More >

QING YIN¹, CAIHONG LIU¹, WENYING JIANG¹, HAIHUI GONG¹, CHUNYUN LI^1,2,3,*, ZUPING HE^1,2,3,*

BIOCELL, Vol.47, No.1, pp. 33-39, 2023, DOI:10.32604/biocell.2023.023567

Abstract Yes-associated protein 1 (YAP1) is a downstream effector of the Hippo signaling pathway, and it is involved in tumorigenesis, tissue repair, growth, and development. In this review, the biological roles and the mechanisms of YAP1 in mediating stem cell fate decisions are discussed, including cell proliferation, differentiation, and apoptosis. In general, YAP1 promotes the proliferation and differentiation of stem cells, including embryonic stem cells and adult stem cells. It inhibits apoptosis by binding to the transcription factors, e.g., transcriptional enhanced associate domain (TEAD), Smad, runt-related transcription factor 1/2, p73, p63, and Erb84, to maintain tissue homeostasis. The translocalization of YAP1… More >

BINFEN HOU¹, LI ZHAO¹, T IANHAO ZHAO¹, MINGMING YANG¹, WANWAN ZHU¹, XIAODONG CHEN², XIQUAN KE¹, ZHENZENG MA¹, LIN GU¹, MENG WANG¹, MIN DENG^1,*

BIOCELL, Vol.47, No.1, pp. 175-186, 2023, DOI:10.32604/biocell.2022.021359

Abstract Aim: Gastric cancer (GC) is one of the most common malignant tumors. Chrysophanol has been reported to possess antitumor effects on a variety of cancers; however, its role in GC remains unclear. This study aimed to investigate the effects of chrysophanol on the proliferation, pyroptosis, migration, and invasion of GC cells. Methods: Human GC cell lines MKN 28 and AGS cells were treated with different concentrations of chrysophanol, then cell proliferation, migration, invasion and pyroptosis were determined by CCK-8, colony-forming assay, wound healing assay, Transwell assay, and flow cytometry. Cell migration and invasion were reassessed in these transfected cells following… More >

Dongliang Zhu^1,*, Jun Yang², Jiaxin Xu³

Oncologie, Vol.24, No.3, pp. 471-482, 2022, DOI:10.32604/oncologie.2022.024062

Abstract G-protein coupled estrogen receptor (GPER) is a transmembrane receptor that mediates non-genomic effects of estrogen. This study aimed to investigate the role of GPER in the stemness formation and malignancies in triple negative breast cancer (TNBC) cells. Spheroids of MDA-MB-468 cells were induced by mammosphere culture, and the proportion of the CD44⁺ /CD24^−/low stem cell subpopulation was detected. Malignant characteristics, expression of GPER and stemness-related markers, and tumorigenesis in a xenograft assay were compared between the mammospheres and adherent cultured cells. The impacts of 17β-estradiol (E2) and the GPER-specific antagonist G15 were studied in in vitro assays. The proportion of… More >

Shaopeng Li, Peng Wang, Jun Qiu, Yiju Xie, Dawei Yin, Kexue Deng^*

Oncologie, Vol.24, No.3, pp. 527-538, 2022, DOI:10.32604/oncologie.2022.022815

Abstract Background: To compare the differential diagnostic value of iterative decomposition of water and fat with the echo asymmetrical and least-squares estimation quantitation sequence (IDEAL-IQ) with that of intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) in differentiating between alpha fetoprotein (AFP)-negative hepatocellular carcinoma (HCC) and focal nodular hyperplasia (FNH). Materials and Methods: A total of 28 AFP-negative HCC cases and 15 FNH cases were scanned using the IDEAL-IQ and IVIM-DWI magnetic resonance imaging (MRI) protocols. Two radiologists independently assessed the fat fraction (FF) and the iron level surrogate (R2*) derived from the IDEAL-IQ images and the apparent diffusion coefficient (ADC), pure… More >

Pushpa Bhardwaj¹, Susheel Kalia^2,3,*, Amit Kumar¹, Hemant Mittal⁴

Journal of Renewable Materials, Vol.1, No.4, pp. 302-310, 2013, DOI:10.7569/JRM.2013.634123

Abstract The objective of the present study is to elucidate the effect of peroxide treatment and graft copolymerization on water absorption behavior of soy protein fi bers in order to make them suitable as a reinforcing material. Grafting of poly(methyl acrylate) and copolymers was successfully carried out on peroxide-treated soy protein fi bers. Different reaction parameters were optimized in order to get maximum percentage grafting. The grafted fi bers were evaluated for water absorption behavior in deionized water. Maximum grafting has been found at 0.219 mol/l of methyl acrylate, 0.0096:0.145 mol/l of FAS:H₂O₂ , 323 K, and 90minutes. Graft copolymerization results… More >

David Grewell^*, Sean T. Carolan, Gowrishankar Srinivasan

Journal of Renewable Materials, Vol.1, No.4, pp. 231-241, 2013, DOI:10.7569/JRM.2013.634120

Abstract : Soy protein plastic formulations were developed through iterative experimental stages to produce waterstable, soy protein isolate (SPI)-based plastic resins. The protein polymer-based materials are glycerol and water plasticized resins that have been described as thermoplastics [1] by some researchers and have been described as materials that behave similar to thermoplastics upon application of heat and pressure [2]. Previous researchers have developed SPI plastic for various applications, all of which were adversely effected by water absorption. The formulations in this research included anhydride chemistries, such as maleic anhydride (MA), phthalic anhydride (PA), and bifunctional chemistries, such as adipic acid in… More >

Philippe Evon^1,2,*, Ika A. Kartika³, Luc Rigal^1,2

Journal of Renewable Materials, Vol.2, No.1, pp. 52-65, 2014, DOI:10.7569/JRM.2013.634131

Abstract The infl uence of thermo-pressing conditions on the mechanical properties of particleboards obtained from Jatropha press cakes was evaluated in this study. Conditions such as molding temperature and press cake oil content were included. All particleboards were cohesive, with proteins and fibers acting respectively as binder and reinforcing fillers. Generally, it was the molding temperature that most affected particleboard mechanical properties. The most resistant boards were obtained using 200°C molding temperature. Glass transition of proteins then occurred during molding, resulting in effective wetting of the fi bers. At this optimal molding temperature, the best compromise between fl exural properties (7.2… More >

A. Pizzi^1,2,*, C. Zollfrank³, X. Li¹, M. Cangemi¹, A. Celzard⁴

Journal of Renewable Materials, Vol.2, No.3, pp. 230-234, 2014, DOI:10.7569/JRM.2014.634114

Abstract Protein rigid foams based on albumin coreacted with camphor and an aldehyde were converted into silicon carbide (SiC) foams. This was carried out by putting albumin-derived template foams in contact with silicon compounds in liquid phase and calcinating the mix obtained at a relatively low temperature of 500°C to eliminate the protein and leave the SiC foam. The transformation was followed by scanning electron microscopy (SEM) from the natural albumin foams to the gel obtained by infi ltrating them with tetraethyl orthosilicate (TEOS) and to the appearance of the SiC foams after calcination. X-ray diffraction (XRD) and Raman spectra were… More >