ATTALLA EL-KOTT1,2, EMAN ELBEALY3, FAHMY ELSAID1,4, HAITHAM EL-MEKKAWY1, ABD-EL-KARIM ABD-LATEIF5, ABDULALI TAWEEL6, HEBA KHALIFA2, AHMAD KANDEEL5, KAREEM MORSY1,7, ESSAM IBRAHIM1,8,9, MASHAEL MOHAMMED BIN-MEFERIJ10,*
BIOCELL, Vol.45, No.1, pp. 89-101, 2021, DOI:10.32604/biocell.2021.012516
Abstract This study investigates if the anti-tumor effect of Pterostilbene in the SKOV3 ovarian cancer (OC) cell line involves
inhibition of cell metabolism and tested in this effect involves modulating AMPK and Akt-induced regulation of mTORC1.
Initially, SKOV3 cells were cultured in the humidified conditions in DMEM media for 24 h with or without increasing
concentration of Pterostilbene. Then, the cells were incubated with Pterostilbene (IC50 = 50 µM) under similar conditions
with or without pre-incubation with Dorsomorphin, an AMPK inhibitor. In a dose-dependent manner, Pterostilbene
inhibited SKOV3 cell survival and increased their lysate levels of lactate dehydrogenase (LDH) and single-stranded… More >
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