Orlando J. CASTEJÓN*
BIOCELL, Vol.39, No.2-3, pp. 33-40, 2015, DOI:10.32604/biocell.2015.39.033
Abstract Twenty one days old Swiss albino mice that received diphenylhydantoin (25 mg/kg, i.p., daily for
15 days) progressively developed gait alterations, changes of behavior and cerebellar ataxia. Cerebellar slices were
processed by conventional transmission electron microscopy. The body of Purkinje cells exhibited fragmented
limiting plasma membranes, dilated nuclear envelopes, swelling and disassembly of nuclear pores, enlargement
of rough and smooth endoplasmic reticulum and a notable detachment of membrane associated ribosomes, together with distorted vacuoles of smooth endoplasmic reticulum, bizarre shaped and swollen mitochondria with
dilated cristae, as well as disrupted limiting lysosomal membranes. Degenerated axosomatic synapses apparently
corresponding to basket… More >
Login
Register
