Simone Tammaro¹, Francesco Di Fiore², Felice Crocetto³, Celeste Manfredi^1,*, Claudia Collà Ruvolo³, Gianluigi Califano³, Biagio Barone⁴, Davide Arcaniolo¹, Lorenzo Spirito¹, Francesco Paolo Calace², Pasquale Reccia², Ferdinando Fusco¹, Marco De Sio¹, Raffaele Balsamo²

Canadian Journal of Urology, Vol.33, No.2, pp. 249-259, 2026, DOI:10.32604/cju.2025.072617 - 20 April 2026

Abstract Background: Thulium laser vaporization of the prostate (ThuVAP) is an established treatment for benign prostatic obstruction, but its impact on urodynamic parameters remains poorly defined. This study aimed to quantify the de-obstructive efficacy of ThuVAP through pre- and postoperative urodynamic comparisons and to assess the relationship between urodynamic improvement and symptom relief. Methods: In a prospective single-center cohort (June 2022–June 2024), men with urodynamically confirmed obstruction underwent standardized ThuVAP with a 200-W thulium:YAG system. Baseline and 6-month invasive urodynamics and 12-month clinical follow-up were performed. The primary endpoint was the change in the bladder outlet… More >

Serkan Özcan^1,*, Mertcan Dama², Enis Mert Yorulmaz¹, Osman Köse¹, Sacit Nuri Görgel¹, Yiğit Akın¹

Canadian Journal of Urology, Vol.33, No.2, pp. 377-386, 2026, DOI:10.32604/cju.2025.072282 - 20 April 2026

Abstract Objectives: Holmium laser enucleation of the prostate (HoLEP) is an established treatment for benign prostatic hyperplasia (BPH), but early postoperative dysuria and incontinence remain common concerns. The Virtual Basket (VB) mode has been proposed to reduce tissue trauma. This study evaluated whether VB use improves early postoperative recovery without compromising HoLEP efficacy. Methods: We retrospectively analyzed 168 men who underwent HoLEP between September 2023 and September 2024. Patients were categorized into three groups according to laser settings: 100 W Standard (n = 65), 100 W VB (n = 49), and 80 W VB (n =… More >

Qiang Li¹, Lan Wu², Yi Zhang¹, Di Huang³, Song Ou-Yang¹, Jia-Yu Yang³, Bing-Hui Li^3,*, Xian-Tao Zeng^1,3,4,5,*

Canadian Journal of Urology, Vol.33, No.1, pp. 7-20, 2026, DOI:10.32604/cju.2026.076741 - 28 February 2026

Abstract Objective: Current research highlights periodontal disease as a systemic inflammatory condition that may influence extra-oral diseases such as prostatic diseases, which prompted us to explore the potential association. To evaluate whether periodontal disease is associated with an increased risk of prostatic disease, including prostate cancer, benign prostatic hyperplasia (BPH), and prostatitis. Methods: A systematic search of observational studies concerning the relationship between periodontal disease and prostatic disease was performed in online databases PubMed, Embase, Web of Science, Scopus, CENTRAL, CNKI, and WanFang. Searches were conducted from database inception to 31 July 2025. Pooled hazard ratio… More >

Christian Gozzi¹, Bruno Bucca^2,*, Orietta Dalpiaz³, Aldo Brassetti⁴, Luca Matteo Gobbi², Greta Basile², Miroslav Djordjevic^5,6

Canadian Journal of Urology, Vol.33, No.1, pp. 75-82, 2026, DOI:10.32604/cju.2025.068035 - 28 February 2026

Abstract Overview: Surgical management of benign prostatic hyperplasia (BPH) has evolved significantly, incorporating various minimally invasive procedures aimed at reducing morbidity and optimizing patient outcomes. Despite advancements, transurethral approaches continue to pose risks such as urethral strictures and urinary incontinence due to mechanical and thermal stress. To address these limitations, the Suprapubic Transvesical Adenoma Resection of the Prostate (STAR-P) was developed, offering a direct suprapubic route that bypasses the urethra entirely. Recent studies have validated STAR-P as both feasible and safe, emphasizing advantages such as enhanced visualization of the urinary sphincter, minimized urethral trauma, effective hemostasis,… More >

Mustufa Babar^1,*, Farooz Babar², Noah Hawks-Ladds³, Justin Loloi⁴, Michael Ciatto⁵

Canadian Journal of Urology, Vol.33, No.1, pp. 193-199, 2026, DOI:10.32604/cju.2025.066654 - 28 February 2026

Abstract Background: Prostate cancer is a common malignancy, with many men on active surveillance for localized, low-risk disease also experiencing lower urinary tract symptoms (LUTS) from benign prostatic hyperplasia (BPH). Water Vapor Thermal Therapy (WVTT) is a minimally invasive BPH treatment, but its safety and efficacy in this setting are unclear. Case Description: We report three men with localized PCa on active surveillance who underwent WVTT for LUTS. Conclusions: WVTT appears safe and potentially effective in treating LUTS, especially in those with lower-risk disease and smaller prostate volumes. Further research is needed to confirm safety, efficacy, and More >

Norbert Nass^1,2,*, Atanas Ignatov³, Thomas Kalinski¹

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072793 - 24 February 2026

Abstract Objectives: Vascular endothelial growth factor (VEGF) regulates tumor vascularization in response to hypoxia and inflammatory signals. The polyphenol curcumin is supposed to interfere with inflammation-induced VEGF secretion and might therefore support anti-VEGF-based treatments. We aimed to investigate the interaction between curcumin and the inflammatory cytokine Interleukin-1β (IL-1β) for VEGF secretion in breast cancer cell lines representing major breast cancer subtypes. Methods: VEGF in cell cultures was detected by Western blot and enzyme-linked immunosorbent assay (ELISA). Kinase phosphorylation was investigated by Western blotting. Gene expressions were analyzed by correlation tests. VEGF was evaluated in a retrospective… More > Graphic Abstract

Vishal Rastogi^1,#, Deepak Verma^2,#, Saurabh Verma³, Prakash Haloi¹, Shruti Kapoor⁴, Havagiray R. Chitme¹, Nethaji Muniraj^5,*, Priyanka Saroj^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.072620 - 24 February 2026

Abstract Metastatic brain tumors undergo profound metabolic–epigenetic reprogramming driven by the unique constraints of the brain microenvironment. Hypoxia-inducible factor-1α (HIF1α) enhances glycolytic flux, lactate accumulation, and histone lactylation, collectively supporting metastatic colonization and immune evasion. Key metabolites including acetyl-CoA, S-adenosylmethionine (SAM), α-ketoglutarate (α-KG), fumarate, and 2-hydroxyglutarate (2-HG)—directly modify chromatin states by regulating histone acetyltransferases, DNA/histone methyltransferases, and α-KG dependent dioxygenases such as Ten-Eleven Translocation (TET) enzymes and lysine demethylases (KDMs). These metabolic shifts result in aberrant DNA methylation, histone lysine residue at position 27 on Histone H3 (H3K27) trimethylation, and depletion of 5-hydroxymethylcytosine (5hmC), all of… More >

Mehran Tarif¹, Mohammadhossein Homaei^2,*, Abbas Mirzaei³, Babak Nouri-Moghaddam³

CMC-Computers, Materials & Continua, Vol.87, No.1, 2026, DOI:10.32604/cmc.2025.071676 - 10 February 2026

Abstract The Routing Protocol for Low-power and Lossy Networks (RPL) is widely used in Internet of Things (IoT) systems, where devices usually have very limited resources. However, RPL still faces several problems, such as high energy usage, unstable links, and inefficient routing decisions, which reduce the overall network performance and lifetime. In this work, we introduce TABURPL, an improved routing method that applies Tabu Search (TS) to optimize the parent selection process. The method uses a combined cost function that considers Residual Energy, Transmission Energy, Distance to the Sink, Hop Count, Expected Transmission Count (ETX), and More >

Ryan G. McQueen¹, Paulina M. Gutkin², George M. Hoffman³, Ronald K. Woods^4,*

Congenital Heart Disease, Vol.20, No.6, pp. 683-692, 2025, DOI:10.32604/chd.2025.075838 - 10 February 2026

Abstract Objective: The objective of this study was to understand intraoperative risk factors for post-Norwood extracorporeal membrane oxygenation (ECMO) in patients with hypoplastic left heart syndrome (HLHS). Methods: We conducted a retrospective, single-institution review of all patients with HLHS who underwent a Norwood procedure (nadir cardiopulmonary bypass temperature ≤ 22°C) over a 12-year period with quantitative and qualitative analysis. Results: Of 102 Norwood patients, 14 (13.7%) required ECMO. ECMO patients had longer median cardiopulmonary bypass (CPB) times (276 vs. 172 min, p < 0.001) and myocardial ischemic times (98.5 vs 83 min, p = 0.021). Longer CPB time was More >

Eduard Belskikh^1,*, Yuliya Marsyanova², Denis Melnikov³, Oleg Uryasev¹, Valentina Zvyagina²

BIOCELL, Vol.49, No.11, pp. 2093-2123, 2025, DOI:10.32604/biocell.2025.069272 - 24 November 2025

Abstract Elevated homocysteine is a clinically relevant metabolic signal in chronic obstructive pulmonary disease (COPD). Higher circulating levels track with oxidative stress, endothelial dysfunction, mitochondrial impairment, and pulmonary vascular remodeling, rise with disease severity, and may contribute to the excess cardiovascular risk—although effect sizes and causality remain uncertain. This review centers on the homocysteine–carnitine relationship in COPD pathophysiology. Carnitine deficiency, prevalent in COPD, can worsen mitochondrial bioenergetics, promote accumulation of acyl intermediates, and reduce nitric oxide bioavailability via endothelial nitric oxide synthase uncoupling (eNOS). Conversely, restoring carnitine status in experimental and early clinical settings has been… More >