Eduard Belskikh^1,*, Yuliya Marsyanova², Denis Melnikov³, Oleg Uryasev¹, Valentina Zvyagina²

BIOCELL, Vol.49, No.11, pp. 2093-2123, 2025, DOI:10.32604/biocell.2025.069272 - 24 November 2025

Abstract Elevated homocysteine is a clinically relevant metabolic signal in chronic obstructive pulmonary disease (COPD). Higher circulating levels track with oxidative stress, endothelial dysfunction, mitochondrial impairment, and pulmonary vascular remodeling, rise with disease severity, and may contribute to the excess cardiovascular risk—although effect sizes and causality remain uncertain. This review centers on the homocysteine–carnitine relationship in COPD pathophysiology. Carnitine deficiency, prevalent in COPD, can worsen mitochondrial bioenergetics, promote accumulation of acyl intermediates, and reduce nitric oxide bioavailability via endothelial nitric oxide synthase uncoupling (eNOS). Conversely, restoring carnitine status in experimental and early clinical settings has been… More >

Phillip Taboada¹, Rohit R. Badia¹, Dhillon Advano¹, Andrew Murphy¹, Christina Sze¹, Ryan J. Mauck¹, Jennifer Tse¹, Jeffrey Gahan², Claus G. Roehrborn¹, Ramy Goueli^1,*

Canadian Journal of Urology, Vol.32, No.5, pp. 491-499, 2025, DOI:10.32604/cju.2025.068150 - 30 October 2025

Abstract Background: Aquablation is a robotic-assisted, water jet-based transurethral therapy for benign prostatic hyperplasia (BPH). Concerns about postoperative hematuria led to the practice of limited transurethral resection (TUR) with cauterization. This study aimed to assess the impact of tranexamic acid (TXA) on hematuria outcomes when combined with limited TUR after Aquablation. Methods: We retrospectively analyzed men undergoing Aquablation at our institution (October 2020–July 2024). Demographic, prostate, surgical, and hematuria outcomes were extracted from electronic medical records. Kruskal-Wallis test compared medians. Results: Of 131 patients, 113 (86%) had limited TUR; 31 (27%) received 1 g TXA perioperatively. TXA… More >

Ozgu Aydogdu^1,*, Onur Erdemoglu², Halil Ibrahim Bozkurt², Tansu Degirmenci², Michael Winder³

Canadian Journal of Urology, Vol.32, No.5, pp. 529-538, 2025, DOI:10.32604/cju.2025.064564 - 30 October 2025

Abstract Objectives: Treatment of patients with lower urinary tract symptoms (LUTS) is often challenging. In men, the origin of LUTS, in particular overactive bladder (OAB) symptoms, is often due to prostate enlargement. However, patients with chronic prostate inflammation (CPI) also frequently experience OAB. Thus far, it is not known if the inflammation per se or concomitant prostate enlargement is the underlying cause of LUTS. Currently, we aim to examine if there is any correlation between CPI and the persistence of OAB symptoms in patients with benign prostate hyperplasia (BPH). Methods: Fifty-one men underwent transurethral resection of… More >

Huan Liu^1,#, Yan Li^2,#, Jizhang Qiu¹, Junchao Zhang¹, Huan Lai¹, Xinhua Zhang^1,*

Canadian Journal of Urology, Vol.32, No.4, pp. 255-269, 2025, DOI:10.32604/cju.2025.066523 - 29 August 2025

Abstract Benign prostatic hyperplasia (BPH) represents a prevalent etiology of lower urinary tract symptoms (LUTS) in the male population, clinically defined by a non-malignant proliferation of prostatic tissue. While BPH exhibits a high prevalence among older male populations globally, the precise underlying mechanisms contributing to its development remain incompletely elucidated. Mitochondria, essential organelles within eukaryotic cells, are critical for cellular bioenergetics, the regulation of reactive oxygen species (ROS) generation, and the modulation of cell death pathways. The maintenance of mitochondrial homeostasis involves a complex interplay of processes. By synthesizing previous literature, this review discusses mitochondrial homeostasis More >

Iqbal Singh^1,*, Himanshu Agrawal², Vidhi Maurya², Sanjay Gupta², Alpana Raizada³

Canadian Journal of Urology, Vol.32, No.4, pp. 299-308, 2025, DOI:10.32604/cju.2025.064827 - 29 August 2025

Abstract Objectives: Benign prostatic hyperplasia (BPH) is a common benign tumor in men, with an age-related prevalence of multifactorial etiology. The present study aimed to accurately assess and predict the effect of co-existing metabolic syndrome (MtS) upon treatment outcomes of combination medical therapy in select patients of lower urinary tract symptoms (LUTS) due to BPH. Methods: After obtaining informed consent from the patients, 70 eligible patients with LUTS due to BPH with and without MtS were enrolled in this study from September 2022 to January 2024 from the outpatient clinic at the University College of Medical… More >

Matthew S. Lee, Trey R. Sledge, Amanda K. Seyer, Robert Qi, Kevin Koo^*

Canadian Journal of Urology, Vol.32, No.4, pp. 325-333, 2025, DOI:10.32604/cju.2025.064255 - 29 August 2025

Abstract While cystolitholapaxy for bladder stones is commonly performed using a transurethral approach, large or complex stone burdens in patients with complex lower urinary tract anatomy may make this inefficient or infeasible. Percutaneous cystolitholapaxy is a safe, effective, minimally invasive alternative for diverse indications, including patients with benign prostatic hyperplasia, urethral stricture disease, closed bladder neck, continent catheterized channel, or other urinary diversion. In this article, we review the indications for and advantages of percutaneous cystolitholapaxy and describe our step-by-step technique for this procedure, including representative imaging and favored equipment. We also discuss preoperative and postoperative More >

Hailong Li^1,#, Wen Ouyang^2,#, Yiyin Long¹, Yun Peng¹, Ziyi Liu¹, Qi Zhou¹, Rong Xu^1,*, Wei Du^1,*

Oncology Research, Vol.33, No.9, pp. 2549-2571, 2025, DOI:10.32604/or.2025.065050 - 28 August 2025

Abstract Background: The study aimed to explore the clinical value of mitochondrial ribosomal protein L18 (MRPL18) in breast cancer. Methods: Multiple databases were used to validate the expression of MRPL18. The prognostic impact and predictive value of MRPL18 were evaluated by using predictive models. Protein-protein interaction (PPI) networks were constructed by using GeneMANIA. Enrichment analysis is used to explore the signaling pathway regulated by MRPL18. Cell counting kit-8 (CCK-8) assays, colony formation, migration assays, flow cytometry, and xenograft models were employed to evaluate the role of MRPL18 in tumor progression. The immune response of MRPL18 was More >

Maazen Alsabaan¹, Jasmin Praful Bharadiya², Vishwanath Eswarakrishnan³, Adnan Mustafa Cheema⁴, Zaid Bin Faheem⁵, Jehad Ali^6,*

CMC-Computers, Materials & Continua, Vol.85, No.1, pp. 1135-1160, 2025, DOI:10.32604/cmc.2025.066969 - 29 August 2025

Abstract The healthcare sector involves many steps to ensure efficient care for patients, such as appointment scheduling, consultation plans, online follow-up, and more. However, existing healthcare mechanisms are unable to facilitate a large number of patients, as these systems are centralized and hence vulnerable to various issues, including single points of failure, performance bottlenecks, and substantial monetary costs. Furthermore, these mechanisms are unable to provide an efficient mechanism for saving data against unauthorized access. To address these issues, this study proposes a blockchain-based authentication mechanism that authenticates all healthcare stakeholders based on their credentials. Furthermore, also… More >

Atena Shiranzaei^1,*, Emad Alizadeh², Mahdi Rabbani³, Sajjad Bagheri Baba Ahmadi^4,*, Mohsen Tajgardan⁵

CMC-Computers, Materials & Continua, Vol.84, No.3, pp. 5381-5402, 2025, DOI:10.32604/cmc.2025.064414 - 30 July 2025

Abstract The sinkhole attack is one of the most damaging threats in the Internet of Things (IoT). It deceptively attracts neighboring nodes and initiates malicious activity, often disrupting the network when combined with other attacks. This study proposes a novel approach, named NADSA, to detect and isolate sinkhole attacks. NADSA is based on the RPL protocol and consists of two detection phases. In the first phase, the minimum possible hop count between the sender and receiver is calculated and compared with the sender’s reported hop count. The second phase utilizes the number of DIO messages to More >

Xinxin Liu^1,#, Yueyue Zhang^1,#, Rahat Sharif¹, Weiqin Mo², Zhenrong Li¹, Guiling Yang¹, Chao Song¹, Ting Ye^2,*, Changming Chen^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.6, pp. 1695-1709, 2025, DOI:10.32604/phyton.2025.063349 - 27 June 2025

Abstract The color difference of capsicum fruit is closely related to the type and content of pigment in the peel, which is mainly determined by anthocyanins, chlorophyll, and carotenoids. This study used green “CA59” and purple “Z81” pepper fruits as parents to create the F₂ generation. The fruit color of 466 F₂ population was identified, and the extreme individuals from this population were selected for Bulked Segregant Analysis (BSA) using resequencing. Genetic analysis revealed that a pair of genes controls the expression of the purple fruit trait in capsicum. Using functional annotation, expression analysis, and sequencing analysis… More >