MINGCAI ZHANG, TANNER CAMPBELL, SPENCER FALCON, JINXI WANG*
BIOCELL, Vol.47, No.10, pp. 2125-2132, 2023, DOI:10.32604/biocell.2023.030161
Abstract Osteoarthritis (OA), the most common form of joint disease, is characterized clinically by joint pain, stiffness, and deformity. OA is now considered a whole joint disease; however, the breakdown of the articular cartilage remains the major hallmark of the disease. Current treatments targeting OA symptoms have a limited impact on impeding or reversing the OA progression. Understanding the molecular and cellular mechanisms underlying OA development is a critical barrier to progress in OA therapy. Recent studies by the current authors’ group and others have revealed that the nuclear factor of activated T cell 1 (NFAT1), a member of the NFAT… More >
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