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    A Computational Model for Cortical Endosteal Surface Remodeling Induced by Mechanical Disuse

    He Gong∗,†, Ming Zhang

    Molecular & Cellular Biomechanics, Vol.7, No.1, pp. 1-12, 2010, DOI:10.3970/mcb.2010.007.001

    Abstract In mechanical disuse conditions associated with immobilization and microgravity in spaceflight, cortical endosteal surface moved outward with periosteal surface moving slightly or unchanged, resulting in reduction of cortical thickness. Reduced thickness of the shaft cortex of long bone can be considered as an independent predictor of fractures. Accordingly, it is important to study the remodeling process at cortical endosteal surface. This paper presents a computer simulation of cortical endosteal remodeling induced by mechanical disuse at the Basic Multicellular Units level with cortical thickness as controlling variables. The remodeling analysis was performed on a representative rectangular slice of the cross section… More >

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