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    ARTICLE

    Association of hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism with susceptibility to renal cell carcinoma/prostate cancer

    HONGYAN LI1,#, CHUNLING LIAO2,#, WENJUAN WENG2, HONGZHEN ZHONG2, TIANBIAO ZHOU2,*

    BIOCELL, Vol.44, No.2, pp. 257-262, 2020, DOI:10.32604/biocell.2020.08826

    Abstract In this study, we used a meta-analysis method to evaluate the relationship between hypoxia-inducible factor-1α (HIF1α) 1772C/T gene polymorphism (rs 11549465) and renal cell carcinoma (RCC)/prostate cancer risk. We searched for relevant studies (before March 1, 2019) on Cochrane Library, Embase, and PubMed. Studies meeting the inclusion criteria were recruited into this meta-analysis. The outcome of dichotomous data was showed in the way of odds ratios (OR), and 95% confidence intervals (CI) were also counted. In this investigation, there was no association between HIF1α 1772C/T gene polymorphism and susceptibility to RCC in Caucasians, Asians as well as overall populations. In… More >

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