DANILA BOBKOV1,2,3,*, ANASTASIA POLYANSKAYA1, ANASTASIA MUSORINA1, GALINA POLJANSKAYA1
BIOCELL, Vol.46, No.9, pp. 2053-2058, 2022, DOI:10.32604/biocell.2022.019469
Abstract All non-immortalized mesenchymal stem cells have a limited proliferative potential, that is, replicative senescence (RS) is an integral characteristic of the life of all mesenchymal stem cells (MSCs). It is known that one of the important signs of RS is a decrease of cell motility, and that violations of migration processes contribute to the deterioration of tissue regeneration. Therefore, the characterization of the properties of the cell line associated with RS is a prerequisite for the effective use of MSCs in restorative medicine. One of the key proteins regulating cell motility is the small GTPase RhoA. The main purpose of… More >
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