David A de la Garza-Kalife¹, Verónica L Loaiza-Gutiérrez¹, Esther Alhelí Hernández-Tobías², Carlos A González-Villarreal³, Jose Francisco Islas¹, Michelle G Santoyo-Suárez¹, Elsa N Garza-Treviño^1,*, Paulina Delgado-Gonzalez^1,*

Oncology Research, Vol.33, No.9, pp. 2243-2262, 2025, DOI:10.32604/or.2025.065222 - 28 August 2025

Abstract Emerging evidence highlights the potential of bioactive compounds, particularly polyphenols, as adjunctive therapeutic agents in the treatment of pancreatic cancer (PC), one of the most aggressive malignancies. This review focuses on epigallocatechin gallate (EGCG) and resveratrol due to their extensively documented anticancer activity, favorable safety profiles, and their unique ability to modulate multiple signaling pathways relevant to pancreatic tumorigenesis. Among polyphenols, these two have shown superior anti-cancer activity, epigenetic regulatory effects, and synergy with standard chemotherapies in preclinical pancreatic cancer models. Resveratrol exhibits anti-proliferative effects by modulating key signaling pathways, including phosphatidylinositol 3 kinase (PI3K)/protein… More > Graphic Abstract

ARTEM P. GUREEV¹, IRINA S. SADOVNIKOVA¹, EKATERINA V. CHERNYSHOVA¹, EKATERINA P. KRUTSKIKH¹, IRINA B. PEVZNER², LJUBAVA D. ZOROVA², VERONIKA V. NESTEROVA¹, POLINA I. BABENKOVA¹, EGOR Y. PLOTNIKOV^2,*

BIOCELL, Vol.49, No.5, pp. 873-892, 2025, DOI:10.32604/biocell.2025.063557 - 27 May 2025

Abstract Background: Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease (AD). Resveratrol is a promising compound for the treatment of various neurodegenerative diseases, including AD. Aims: To investigate mitochondrial damage and the effects of resveratrol on inflammation, cognitive function, and mitochondrial quality control in APP/PS1 mice. Methods: Comparative analysis of mitochondrial DNA (mtDNA) damage was conducted between 10-month-old APP/PS1 mice and age-matched C57BL/6 mice. Assessments included measurement of amyloid-β levels, inflammatory markers, swimming distance in the Morris water maze, and gut microbiome composition. Resveratrol’s effects on cytokine expression, mtDNA levels in plasma, and… More >

TANVI VIJAY GUJARAN^1,#, VIGNESH BALAJI EASWARAN^1,#, RUNALI SANKHE¹, PUGAZHANDHI BAKTHAVATCHALAM^2,3, HERMAN SUNIL DSOUZA⁴, K. SREEDHARA RANGANATH PAI^1,*

Oncology Research, Vol.33, No.2, pp. 381-395, 2025, DOI:10.32604/or.2024.049538 - 16 January 2025

Abstract Background: To date, there is no effective cure for the highly malignant brain tumor glioblastoma (GBM). GBM is the most common, aggressive central nervous system tumor (CNS). It commonly originates in glial cells such as microglia, oligodendroglia, astrocytes, or subpopulations of cancer stem cells (CSCs). Glucose plays an important role in the, which energy metabolism of normal and cancer cells, but cancer cells exhibit an increased demand for glucose is required for their differentiation and proliferation. The main aim of this study is to explore the anti-cancer efficacy of the ketogenic diet against GBM. Also,… More >

MEIR DJALDETTI^*

Oncology Research, Vol.32, No.9, pp. 1389-1399, 2024, DOI:10.32604/or.2024.049745 - 23 August 2024

Abstract Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells to produce pro-inflammatory cytokines, including IL-1β, IL-6, IL-1ra and TNFα. Considering the close association between chronic inflammation and cancer development, RSV’s immunomodulatory properties are one way by which the polyphenol may inhibit cancer initiation, proliferation, neovascularization, and migration. Resveratrol influences the generation of microtumor environment which is one of the key factors in cancer progress. In addition to immunomodulation, RSV inhibits cancer development by expressing anti-oxidant effects, causing cell cycle… More > Graphic Abstract

MONICA SAVIO, VALENTINA MINOIA, PAOLA FULGHIERI, LUCIA ANNA STIVALA^*, VIRGINIE SOTTILE^*

BIOCELL, Vol.46, No.12, pp. 2525-2530, 2022, DOI:10.32604/biocell.2022.022924 - 10 August 2022

Abstract The nutraceutical resveratrol is associated with a range of biological effects, from antibiotic to anti-inflammatory activities. One major axis of research has sought to harness its anti-tumour potential, with promising preclinical results and early clinical trials. A second strong interest relies on the anti-ageing effects ascribed to the compound and its application to stem cell research. It is becoming clear however that these possible favourable effects are conditioned by a set concentration range not easily controllable in vivo. Here we evoke novel developments in the field that could lead to more reliable conditions for the translational More >