ZHIPING WEI1,2, YAJUN LIU1, MEIWEN YANG3, MENGDI LI1, KEXIN LI1, LUXI ZHENG1, HUIQIONG GUO1, FENFANG HONG4,*, SHULONG YANG1,*
BIOCELL, Vol.45, No.4, pp. 1005-1012, 2021, DOI:10.32604/biocell.2021.014581
Abstract Background and Objective: LTB4 has been shown to be involved in rheumatoid arthritis (RA) pathogenesis.
The effect of Dioscin(Dio) on the LTB4 pathway of RA have not been reported yet. This study aimed at further
exploring whether Dioscin’s effects on TNF-α induced collagen-induced arthritis (CIA) rat fibroblast-like synoviocytes
(FLS) connected with the LTB4 and its receptor pathway. Materials & Methods: In this experiment, control group,
TNF-α group, and different concentrations of Dioscin groups were established. Cell viability was evaluated using
MTT assay. The levels of LTB4 in the samples of above groups were measured using ELISA. The mRNA expression
levels… More >
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