Adilijiang Maimaitiming*, Ailijiang Wusiman†, Abulajiang Aimudula†, Xuekelaiti Kuerban*, Pengcheng Su*
Oncology Research, Vol.28, No.1, pp. 13-19, 2020, DOI:10.3727/096504019X15519249902838
Abstract The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and
progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and
a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in
breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation,
migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target
gene of miR-152 in… More >
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