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  • Open Access


    Procaine Inhibits the Proliferation and Migration of Colon Cancer Cells Through Inactivation of the ERK/MAPK/FAK Pathways by Regulation of RhoA

    Chang Li*, Shuohui Gao*, Xiaoping Li, Chang Li, Lianjun Ma§

    Oncology Research, Vol.28, No.6, pp. 675-679, 2020, DOI:10.3727/096504021X16137463165406

    Abstract Colon cancer is one of the most lethal varieties of cancer. Chemotherapy remains as one of the principal treatment approaches for colon cancer. The anticancer activity of procaine (PCA), which is a local anesthetic drug, has been explored in different studies. In our study, we aimed to explore the anticancer effect of PCA on colon cancer and its underlying mechanism. The results showed that PCA significantly inhibited cell viability, increased the percentage of apoptotic cells, and decreased the expression level of RhoA in HCT116 cells in a dose-dependent manner (p < 0.05 or p < 0.01). Moreover, PCA increased the… More >

  • Open Access


    The RhoA nuclear localization changes in replicative senescence: New evidence from in vitro human mesenchymal stem cells studies


    BIOCELL, Vol.46, No.9, pp. 2053-2058, 2022, DOI:10.32604/biocell.2022.019469

    Abstract All non-immortalized mesenchymal stem cells have a limited proliferative potential, that is, replicative senescence (RS) is an integral characteristic of the life of all mesenchymal stem cells (MSCs). It is known that one of the important signs of RS is a decrease of cell motility, and that violations of migration processes contribute to the deterioration of tissue regeneration. Therefore, the characterization of the properties of the cell line associated with RS is a prerequisite for the effective use of MSCs in restorative medicine. One of the key proteins regulating cell motility is the small GTPase RhoA. The main purpose of… More >

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