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    3D Fluid-Structure Interaction Canine Heart Model with Patch to Quantify Mechanical Conditions for Optimal Myocardium Stem Cell Growth and Tissue Regeneration

    Heng Zuo*, Dalin Tang*,†,‡, Chun Yang*,§, Glenn Gaudette, Kristen L. Billiar, Pedro J. del NidokII

    Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 67-85, 2015, DOI:10.3970/mcb.2015.012.067

    Abstract Right ventricular (RV) dysfunction is a common cause of heart failure in patients with congenital heart defects and often leads to impaired functional capacity and premature death. Myocardial tissue regeneration techniques are being developed for the potential that viable myocardium may be regenerated to replace scar tissues in the heart or used as patch material in heart surgery. 3D computational RV/LV/Patch models with fluid-structure interactions (FSI) were constructed based on data from a healthy dog heart to obtain local fluid dynamics and structural stress/strain information and identify optimal conditions under which tissue regeneration techniques could… More >

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