Darío E. IGLESIAS*, Silvina S. BOMBICINO, Alberto BOVERIS, Laura B. VALDEZ
BIOCELL, Vol.40, No.1, pp. 27-30, 2016, DOI:10.32604/biocell.2016.40.027
Abstract Complex III plays a central role in the mitochondrial respiratory chain transferring electrons from
ubiquinol to cytochrome c and pumping protons to the intermembrane space, contributing to the protonmotive
force. Furthermore, complex III can act as a source of O2
•- in the presence of ubiquinol and antimycin, an
expermiental condition in which the oxidation of the cytochrome b hemes is blocked. The O2
•- dismutation
catalyzed by superoxide dismutase produces H2O2, a known second messenger in redox signalling. Results from
our laboratory have shown that NO, released from GSNO or from SPER -NO or generated by mtNOS, inhibits
electron… More >
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