Anoud Bani-Hani^1,*, Anaïs Lavorel², Newel Bessadet³

CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 3895-3913, 2021, DOI:10.32604/cmc.2021.015355 - 06 May 2021

Abstract Since December 2019, a new pandemic has appeared causing a considerable negative global impact. The SARS-CoV-2 first emerged from China and transformed to a global pandemic within a short time. The virus was further observed to be spreading rapidly and mutating at a fast pace, with over 5,775 distinct variations of the virus observed globally (at the time of submitting this paper). Extensive research has been ongoing worldwide in order to get a better understanding of its behaviour, influence and more importantly, ways for reducing its impact. Data analytics has been playing a pivotal role… More >

Wael Alosaimi¹, Rajeev Kumar^2,*, Abdullah Alharbi¹, Hashem Alyami³, Alka Agrawal⁴, Gaurav Kaithwas⁵, Sanjay Singh⁶, Raees Ahmad Khan⁴

Intelligent Automation & Soft Computing, Vol.28, No.3, pp. 617-628, 2021, DOI:10.32604/iasc.2021.016703 - 20 April 2021

Abstract COVID-19 pandemic has unleashed an unprecedented humanitarian crisis in the world at present. With each passing day, the number of patients afflicted with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is rising at an alarming pace, so much so that some countries are now combating the second wave of the contagion. As the death ratio due to the Virus increases, the medical fraternity and pharmacologists are working relentlessly to identify and prescribe a standardized and effective course of treatment for treating COVID-19 patients. However, medical specialists are confused about opting for the most efficacious course… More >

YASHVI SHARMA, SUCHI GUPTA, SUJATA MOHANTY^*

BIOCELL, Vol.45, No.3, pp. 517-520, 2021, DOI:10.32604/biocell.2021.014621 - 03 March 2021

Abstract In these times of despair when a nano-sized organism, the SARS-CoV-2, has rendered the human race helpless, made the global health status decline, and drowned the world economy, a ray of hope comes from another nano-sized particle, the exosome. The potential of mesenchymal stem cells has already been established in COVID-19; however, cell-based therapy has its risks. We thereby propose cell-free therapy using stem cells-derived exosomes to fight against COVID-19, as they can be a game-changer owing to their immunomodulatory nature, which combats the cytokine storm characterizing this disease, and their practical efficiency, which will More >

Huma¹, Muhammad Khalid Sohail², Nadeem Akhtar³, Dost Muhammad³, Humaira Afzal⁴, Muhammad Rafiq Mufti⁵, Shahid Hussain^6,*, Mansoor Ahmed¹

CMC-Computers, Materials & Continua, Vol.67, No.3, pp. 3737-3748, 2021, DOI:10.32604/cmc.2021.014398 - 01 March 2021

Abstract This study aims to identify the potential association of mental health and social media forum during the outbreak of COVID-19 pandemic. COVID-19 brings a lot of challenges to government globally. Among the different strategies the most extensively adopted ones were lockdown, social distancing, and isolation among others. Most people with no mental illness history have been found with high risk of distress and psychological discomfort due to anxiety of being infected with the virus. Panic among people due to COVID-19 spread faster than the disease itself. The misinformation and excessive usage of social media in… More >

Fahad Ahmad^1,*, Saleh N. Almuayqil², Mamoona Humayun², Shahid Naseem³, Wasim Ahmad Khan⁴, Kashaf Junaid⁵

CMC-Computers, Materials & Continua, Vol.66, No.3, pp. 2265-2282, 2021, DOI:10.32604/cmc.2021.013067 - 28 December 2020

Abstract COVID-19 is a pandemic that has affected nearly every country in the world. At present, sustainable development in the area of public health is considered vital to securing a promising and prosperous future for humans. However, widespread diseases, such as COVID-19, create numerous challenges to this goal, and some of those challenges are not yet defined. In this study, a Shallow Single-Layer Perceptron Neural Network (SSLPNN) and Gaussian Process Regression (GPR) model were used for the classification and prediction of confirmed COVID-19 cases in five geographically distributed regions of Asia with diverse settings and environmental… More >

Kashaf Junaid^1,*, Sumera Qasim², Humaira Yasmeen³, Hasan Ejaz¹, Abdullah Alsrhani¹, Muhammad Ikram Ullah¹, Fahad Ahmad⁴, Abdul Rehman⁵

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 707-714, 2021, DOI:10.32604/cmc.2020.012976 - 30 October 2020

Abstract Coronavirus disease 2019 (COVID-19) is a current pandemic that has affected more than 195 countries worldwide. In this severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, when treatment strategies are not yet clear and vaccines are not available, vitamins are an excellent choice to protect against this viral infection. The rationale behind this study was to examine the inhibitory effect of vitamins B, C, and D against the main protease of SARSCoV-2 and angiotensin-converting enzyme 2 (ACE2), which have critical rolesin the immune system. Molecular docking, performed by using MOE-Dock of the Chemical Computing Group,… More >

Abdu Gumaei^1,2,*, Mabrook Al-Rakhami¹, Mohamad Mahmoud Al Rahhal³, Fahad Raddah H. Albogamy³, Eslam Al Maghayreh³, Hussain AlSalman¹

CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 315-329, 2021, DOI:10.32604/cmc.2020.012045 - 30 October 2020

Abstract The fast spread of coronavirus disease (COVID-19) caused by SARSCoV-2 has become a pandemic and a serious threat to the world. As of May 30, 2020, this disease had infected more than 6 million people globally, with hundreds of thousands of deaths. Therefore, there is an urgent need to predict confirmed cases so as to analyze the impact of COVID-19 and practice readiness in healthcare systems. This study uses gradient boosting regression (GBR) to build a trained model to predict the daily total confirmed cases of COVID-19. The GBR method can minimize the loss function More >

Benjamin Schrijver^1,a, Jorn L. J. C. Assmann^1,a, Adriaan J. van Gammeren², Roel C. H. Vermeulen³, Lützen Portengen³, Peter Heukels⁴, Anton W. Langerak¹, Willem A. Dik¹, Vincent H. J. van der Velden^1,b, Ton A. A. M. Ermens^2,b

European Cytokine Network, Vol.31, No.4, pp. 154-167, 2020, DOI:10.1684/ecn.2020.0456

Abstract COVID-19 differs substantially between individuals, ranging from mild to severe or even fatal. Heterogeneity in the immune response against SARS-COV-2 likely contributes to this. Therefore, we explored the temporal dynamics of key cellular and soluble mediators of innate and adaptive immune activation in relation to COVID-19 severity and progression.
Forty-four patients with a PCR-proven diagnosis of COVID-19 were included. Extensive cellular (leukocytes and T-lymphocyte subsets) and serological immune profiling (cytokines, soluble cell surface molecules, and SARS-CoV-2 antibodies) was performed at hospital admission and every 3-4 days during hospitalization. Measurements and disease outcome were compared between… More >

Vipin Tyagi¹, Ajay Kumar Sharma², Mahendra Bhandari³

Canadian Journal of Urology, Vol.27, No.3, pp. 10205-10212, 2020

Abstract Introduction: The novel coronavirus disease 2019 (COVID-19) pandemic has afflicted > 3.3 million people around the world since December 2019. Though more than 1000 publications have appeared in scientific journals addressing a plethora of questions, there is a considerable hiatus in understanding the behavior and natural history of the virus and its impact on urology. Also, a modified approach is the need of the hour in taking care of patients, as urologists should safeguard their teams, families, and patients.
Material and methods: The authors have used guidelines from the USA, Canada, UK, Europe, and India for making… More >

VIVEK KUMAR, VISHNU AGARWAL^*

BIOCELL, Vol.44, No.4, pp. 461-467, 2020, DOI:10.32604/biocell.2020.011090 - 24 December 2020

Abstract The world is facing a new healthcare crisis with the rise and spread of novel coronavirus since December 2019. Also known as Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2), the disease associated with SARSCoV-2 is even called COVID-19. The infection is said to have originated from the bat community and transmitted to humans through an intermediate host (yet unknown) in Wuhan, in the Hubei region of China. COVID-19 is having a pulverizing impact on the scientific community. As of August 13, 2020, the number of confirmed cases had reached up to 20,439,814 and the death More >