SANDRA STICKLER1, BARBARA RATH1, MAXIMILIAN HOCHMAIR2, CLEMENS LANG3, LUKAS WEIGL4, GERHARD HAMILTON1,*
Oncology Research, Vol.31, No.1, pp. 13-22, 2023, DOI:10.32604/or.2022.027281
Abstract Small cell lung cancer (SCLC) is frequently disseminated and has a dismal prognosis with survival times of
approximately two years. This cancer responds well to initial chemotherapy but recurs within a short time as a
globally chemoresistant tumor. Circulating tumor cells (CTCs) are held responsible for metastasis, the extremely high
numbers of these cells in advanced SCLC allowed us to establish several permanent CTC cell lines. These CTCs are
distinguished by the spontaneous formation of large spheroids, termed tumorospheres, in regular tissue culture. These
contain quiescent and hypoxic cells in their interior and are associated with high chemoresistance compared to… More >
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