Wu Feng^1,2,*, Tengku Anita Raja Hussin¹, Xu Yang³

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071664 - 08 January 2026

Abstract This study investigates the thermo–mechanical behavior of C40 concrete and reinforced concrete subjected to elevated temperatures up to 700°C by integrating experimental testing and advanced numerical modeling. A temperature-indexed Concrete Damage Plasticity (CDP) framework incorporating bond–slip effects was developed in Abaqus to capture both global stress–strain responses and localized damage evolution. Uniaxial compression tests on thermally exposed cylinders provided residual strength data and failure observations for model calibration and validation. Results demonstrated a distinct two-stage degradation regime: moderate stiffness and strength reduction up to ~400°C, followed by sharp deterioration beyond 500°C–600°C, with residual capacity at… More >

Hüseyin Bilgin^*, Bredli Plaku

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071007 - 08 January 2026

Abstract Nonlinear static procedures are widely adopted in structural engineering practice for seismic performance assessment due to their simplicity and computational efficiency. However, their reliability depends heavily on how the nonlinear behaviour of structural components is represented. The recent earthquakes in Albania (2019) and Türkiye (2023) have underscored the need for accurate assessment techniques, particularly for older reinforced concrete buildings with poor detailing. This study quantifies the discrepancies between default and user-defined component modelling in pushover analysis of pre-modern reinforced concrete structures, analysing two representative low- and mid-rise reinforced concrete frame buildings. The lumped plasticity approach… More > Graphic Abstract

Zhangdi Xie^1,2,*, Cantao Zhuang¹, Yong Wu¹, Linghui Niu¹, Jianming Zhao³

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.070531 - 08 January 2026

Abstract This study employed tri-component continuous monitoring data from 10 measurement points on both sides of a base isolation layer in the basement of a large-span high-rise building in Beijing, as well as from a free-field station and roof frame, during a M_w 5.5 magnitude earthquake in Pingyuan, Shandong, in 2023. The H/V spectral ratio method was used to evaluate the structural dynamic response characteristics of the building and analyze the regulatory effect of the base-isolation layer on seismic waves. The results indicate that during the earthquake, the peak frequency of the free-field and the measurement points… More >

Zhengyan Chang, Weiwei Wang, Mingliang Yang, Heng Yang, Qing Dong, Keyuan Zhao, Jie Yuwen^*

Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.066572 - 08 January 2026

Abstract To address the neglect of seismic performance in conventional double-girder bridge crane optimization, this paper introduces a time-history analysis-based seismic optimization methodology for crane structures. Using a 25-t nuclear power crane as a case study, a bridge frame finite element model is established and validated through static analysis, confirming its accurate representation of the physical entity’s mechanical behavior. Furthermore, with bridge mass reduction as the objective and structural strength, stiffness, stability, and seismic mechanical performance as constraints, an optimization model is developed employing the Whale Optimization Algorithm (WOA). More >

Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

Sandra Kałużna^1,*, Monika Świerczewska^1,2, Sylwia Ciesiółka¹, Małgorzata Partyka¹, Michał Nowicki¹, Karolina Wojtowicz¹

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070356 - 30 December 2025

Abstract The last research focuses on the role of exosomes in cancer treatment. Exosomes are extracellular vesicles. They can be secreted by cancer cells, and they can modulate chemotherapy sensitivity. Determining exosomal content opens the possibility for guiding treatment strategies for cancer diseases. Exosomal microRNA are considered one of the prime candidates for exosomal biomarkers. Exosomal circular RNAs represent excellent biomarkers for liquid biopsy because of their stability in many types of cancer. Exosomal proteins remain reliable biomarkers also. Exosomes have emerged as promising therapeutic candidates. Their biological properties render them ideal vectors for drug delivery.… More >

Kai Gui^1,#, Tianyi Yang^1,#, Chengying Xiong¹, Yue Wang¹, Zhiqiang He¹, Wuxian Li^2,3,*, Min Tang^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070143 - 30 December 2025

Abstract Objectives: The mechanism by which specific tumor subsets in colorectal cancer (CRC) use alternative metabolic pathways, particularly those modulated by hypoxia and fructose, to alter the tumor microenvironment (TME) remains unclear. This study aimed to identify these malignant subpopulations and characterize their intercellular signaling networks and spatial organization through an integrative multi-omics approach. Methods: Leveraging bulk datasets, single-cell RNA sequencing, and integrative spatial transcriptomics, we developed a prognostic model based on hypoxia-and fructose metabolism-related genes (HFGs) to delineate tumor cell subpopulations and their intercellular signaling networks. Results: We identified a specific subset of stanniocalcin-2 positive (STC2+)… More > Graphic Abstract

Shujie Yin¹, Zong Li¹, Wen-Bin Ou^1,2,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069049 - 30 December 2025

Abstract Ferroptosis is an iron-dependent, excessive lipid peroxidation-driven form of regulated cell death. The core mechanisms of ferroptosis include lipid peroxidation cascade, System X_c⁻-glutathioneglutathione peroxidase 4 axis, iron and lipid metabolism chaos, the NAD(P)Hferroptosis suppressor protein 1—ubiquinone axis, and GTP cyclohydrolase 1 tetrahydrobiopterin-dihydrofolate reductase axis. Cuproptosis is triggered by copper ions and involves ferredoxin 1-mediated aggregation of lipoylated proteins, differing fundamentally from ferroptosis. Both ferroptosis and cuproptosis exhibit dual roles (promote or inhibit) in cancers. And the sensitivity of different cancer types to ferroptosis varies, which may depend on special metabolic signatures (e.g., E-cadherin loss causes epithelial–mesenchymal More > Graphic Abstract

Yimin Liu^1,#, Bin Liu^2,3,4,#, Huabin Gao¹, Jinlong Wang⁵, Jingya Duan¹, Xiaolan Huang¹, Yuexi Liu¹, Ying Huang¹, Wenjing Liao¹, Ruonan Li^1,*, Hua Linghu^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069007 - 30 December 2025

Abstract Objectives: High-grade serous ovarian cancer (HGSOC), the most common subtype of epithelial ovarian cancer (EOC), exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis. Human epididymis protein 4 (HE4), a key diagnostic biomarker for ovarian cancer, is involved in fibrotic processes in several non-malignant diseases. Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis, this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC. Methods: A total of 126 patients with gynecological conditions were included and divided into… More > Graphic Abstract