Hong Chen^1,2, Runze Yang^1,2, Jing Tian^1,2, Boyuan Xu^1,2, Qiang Chen³, Yuzong Chen^1,2, Ming-Xiao Zhao^1,2,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2025.072276 - 30 January 2026

Abstract Panax species are globally recognized for their high medicinal and economic value, yet large-scale cultivation is constrained by high production costs, progressive soil acidification, and persistent soil-borne diseases. Although various soil improvement strategies have been tested, a comprehensive synthesis of their comparative effectiveness has been lacking. Here, we conducted a meta-analysis of 1381 observations from 54 independent studies to evaluate the effects of conventional fertilizers, microbial fertilizers, organic amendments, and inorganic amendments on Panax cultivation. Our results demonstrate that microbial fertilizers, organic amendments, and inorganic amendments significantly increased soil pH, thereby ameliorating soil acidification. Among them,… More >

Mong-Fong Horng^1,#, Thanh-Lam Nguyen^1,#, Thanh-Tuan Nguyen^2,*, Chin-Shiuh Shieh^1,*, Lan-Yuen Guo³, Chen-Fu Hung⁴, Chun-Chih Lo¹

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.075064 - 29 January 2026

Abstract The global population is rapidly expanding, driving an increasing demand for intelligent healthcare systems. Artificial intelligence (AI) applications in remote patient monitoring and diagnosis have achieved remarkable progress and are emerging as a major development trend. Among these applications, mouth motion tracking and mouth-state detection represent an important direction, providing valuable support for diagnosing neuromuscular disorders such as dysphagia, Bell’s palsy, and Parkinson’s disease. In this study, we focus on developing a real-time system capable of monitoring and detecting mouth state that can be efficiently deployed on edge devices. The proposed system integrates the Facial… More >

Min Hee Kim¹, Boyoon Huh¹, Joo-Won Park^1,*, Woo-Jae Park^2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071523 - 19 January 2026

Abstract Breast cancer is one of the most prevalent malignancies among women and comprises a heterogeneous spectrum of molecular subtypes with distinct biological behaviors. Among various regulatory molecules, sphingolipids play pivotal roles in dynamically modulating fundamental cellular processes such as proliferation, apoptosis, and metastasis through metabolic interconversions, including phosphorylation, glycosylation, and the generation of sphingosine-1-phosphate. This review aims to elucidate the mechanisms through which sphingolipid metabolism orchestrates cancer cell fate and drives breast cancer progression. Particular emphasis is placed on the balance between proapoptotic ceramides and pro-survival metabolites, such as sphingosine-1-phosphate, which collectively influence tumor growth More >

Bu Zou^1,#, Yi-En Xu^2,#, Hui-Chan He³, Zu-Lu Ye², Da-Lei Zhou², Cai-Yun He^2,*, Chan Huang^4,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.069453 - 19 January 2026

Abstract Objectives: Gastric cancer (GC) remains a major global health concern, and Phosphoinositide-3-Kinase Regulatory Subunit 1 (PIK3R1), a regulatory subunit of the PI3K signaling pathway, may play a critical yet underexplored role in GC progression. This study aimed to investigate the prognostic significance of PIK3R1 in GC and its association with the tumor immune microenvironment. Methods: PIK3R1 expression and its clinical relevance were analyzed using datasets from GC patients who underwent gastrectomy, including cohorts from The Cancer Genome Atlas (TCGA) and the Sun Yat-sen University Cancer Center (SYSUCC). Prognostic models integrating PIK3R1 expression with clinical parameters… More >

Sarra B. Shakartalla^1,2,3, Iman M. Talaat^1,2,4,*, Nival Ali¹, Shahenaz S. Salih^1,5, Zainab M. Al Shareef^1,2, Noura Alkhayyal⁶, Riyad Bendardaf^2,7,*, Sameh S. M. Soliman^1,8,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070808 - 30 December 2025

Abstract Objectives: Breast cancer (BC) is the leading cause of cancer-related mortality in women, largely due to metastasis. This study aims to explore the role of purine nucleoside phosphorylase (PNP), a key enzyme in purine metabolism, in the aggressiveness and metastatic behavior of BC. Methods: A comprehensive analysis was performed using in silico transcriptomic data (n = 2509 patients), immunohistochemical profiling of BC tissues (n = 103), and validation through western blotting in multiple BC cell lines. Gene expression and survival analyses were conducted using Tumor Immune Estimation Resource (TIMER), Gene Expression Profiling Interactive Analysis 2 (GEPIA2), and… More >

Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong^*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

Jing Cai^1,#, Haoyun Zhu^1,#, Weiling Guo¹, Ting Huang¹, Pangzhou Chen^1,2, Wen Zhou¹, Ziyun Guan^1,3,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069902 - 30 December 2025

Abstract Background: Therapeutic responses of breast cancer vary among patients and lead to drug resistance and recurrence due to the heterogeneity. Current preclinical models, however, are inadequate for predicting individual patient responses towards different drugs. This study aimed to investigate the patient-derived breast cancer culture models for drug sensitivity evaluations. Methods: Tumor and adjacent tissues from female breast cancer patients were collected during surgery. Patient-derived breast cancer cells were cultured using the conditional reprogramming technique to establish 2D models. The obtained patient-derived conditional reprogramming breast cancer (CRBC) cells were subsequently embedded in alginate-gelatin methacryloyl hydrogel microspheres… More >

Chia-Hui Liu^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-18, 2026, DOI:10.32604/cmc.2025.072887 - 09 December 2025

Abstract The Industrial Internet of Things (IIoT) has emerged as a cornerstone of Industry 4.0, enabling large-scale automation and data-driven decision-making across factories, supply chains, and critical infrastructures. However, the massive interconnection of resource-constrained devices also amplifies the risks of eavesdropping, data tampering, and device impersonation. While digital signatures are indispensable for ensuring authenticity and non-repudiation, conventional schemes such as RSA and ECC are vulnerable to quantum algorithms, jeopardizing long-term trust in IIoT deployments. This study proposes a lightweight, stateless, hash-based signature scheme that achieves post-quantum security while addressing the stringent efficiency demands of IIoT. The… More >

Liangjian Lei^1,2, Yihang Lu^1,2,*

Frontiers in Heat and Mass Transfer, Vol.23, No.6, pp. 2109-2126, 2025, DOI:10.32604/fhmt.2025.072643 - 31 December 2025

Abstract Internal thermal mass, such as furniture and partitions, plays a crucial role in enhancing building energy efficiency and indoor thermal comfort by passively regulating temperature fluctuations. However, the irregular geometry of these elements poses a significant challenge for accurate modeling in building energy simulations. This study addresses this gap by developing a rigorous analytical model that idealizes internal thermal mass as a sphere, thereby capturing multi-directional heat conduction effects that are neglected in simpler one-dimensional slab models. The transient heat conduction within the sphere is solved analytically using Duhamel’s theorem for three representative indoor air… More >

Hasan Jhaveri^*, Mariela Martinez-Rivera, Brent Nose, Jordan Foreman, Aaron C. Lentz

Canadian Journal of Urology, Vol.32, No.6, pp. 597-603, 2025, DOI:10.32604/cju.2025.068095 - 30 December 2025

Abstract Objectives: There is limited in vivo data on the maximum safe instrument size that can be passed through an artificial urinary sphincter (AUS) cuff. While 21 French instruments are generally safe with the commonly used 4.5 cm cuff, larger instruments or smaller cuffs may require unbuckling to avoid urethral erosion. This study aimed to identify if artificial urinary sphincter cuff ‘unbuckling’ affects device longevity and risk of erosion. Methods: A retrospective study of patients at a quaternary health system who underwent unbuckling was conducted. Using the Epic Clarity database and Duke Enterprise Data Unified Content Explorer… More >