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  • Open Access

    ARTICLE

    Performance Characterization of CR/PU Asphalt for Potential Application in Assembled Fast-Repairing Engineering

    Hong Pang1, Ao Lu1, Ming Xiong1, Chen Chen1, Xian Cao1, Xiong Xu2,3,*, Jing Wang1

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1063-1074, 2024, DOI:10.32604/fdmp.2023.044000

    Abstract Conventional repairing methods for asphalt pavement have some inconveniences, such as insufficient strength, and are typically time-consuming. To address these issues, this study proposes a new technological method to design and prepare a high-performance assembled asphalt concrete block for fast repair of the potholes. A series of composite modified asphalt binders with 10% crumb rubber (CR) and different dosages (0%, 1%, 3%, 5%) of polyurethane (PU) are examined to determine the optimized binder. Subsequently, the corresponding asphalt mixtures are prepared for further comparison and assessment of engineering properties, such as moisture-induced damage, high-temperature deformation, and More >

  • Open Access

    ARTICLE

    Smoothed-Particle Hydrodynamics Simulation of Ship Motion and Tank Sloshing under the Effect of Regular Waves

    Mingming Zhao, Jialong Jiao*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 1045-1061, 2024, DOI:10.32604/fdmp.2023.043744

    Abstract Predicting the response of liquefied natural gas (LNG) contained in vessels subjected to external waves is extremely important to ensure the safety of the transportation process. In this study, the coupled behavior due to ship motion and liquid tank sloshing has been simulated by the Smoothed-Particle Hydrodynamics (SPH) method. Firstly, the sloshing flow in a rectangular tank was simulated and the related loads were analyzed to verify and validate the accuracy of the present SPH solver. Then, a three-dimensional simplified LNG carrier model, including two prismatic liquid tanks and a wave tank, was introduced. Different More >

  • Open Access

    ARTICLE

    A Study on the Performances of Solar Air Collectors Having a Hemispherical Dimple on the Absorber Plate

    Shuilian Li1, Fan Zeng1, Xinli Wei2,*

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.5, pp. 939-955, 2024, DOI:10.32604/fdmp.2023.043614

    Abstract In order to increase the efficiency of solar air collectors, a new variant with a protrusion is proposed in this study, and its performances are analyzed from two points of view, namely, in terms of optics and thermodynamics aspects. By comparing and analyzing the light paths of the protrusion and the dimple, it can be concluded that when sunlight shines on the dimple, it is reflected and absorbed multiple times, whereas for the sunlight shining on the protrusion, there is no secondary reflection or absorption of light. When the lighting area and the properties of… More >

  • Open Access

    ARTICLE

    Long Noncoding RNA MEG3 Suppresses Glioma Cell Proliferation, Migration, and Invasion by Acting as a Competing Endogenous RNA of miR-19a

    Nan Qin*1, Gui-Feng Tong†1, Li-Wei Sun, Xiao-Lin Xu

    Oncology Research, Vol.25, No.9, pp. 1471-1478, 2017, DOI:10.3727/096504017X14886689179993

    Abstract Glioma, with varying malignancy grades and histological subtypes, is the most common primary brain tumor in adults. Long noncoding RNAs (lncRNAs) are non-protein-coding transcripts and have been proven to play an important role in tumorigenesis. Our study aims to elucidate the combined effect of lncRNA maternally expressed gene 3 (MEG3) and microRNA-19a (miR-19a) in human glioma U87 and U251 cell lines. Real-time PCR revealed that MEG3 was downregulated and miR-19a was upregulated in malignant glioma tissues and cell lines. Bioinformatics analyses (TargetScan, miRanda, and starBase V2.0) showed that phosphatase and tensin homolog (PTEN) is a… More >

  • Open Access

    ARTICLE

    3-Phosphoinositide Dependent Protein Kinase-1 (PDK-1) Promotes Migration and Invasion in Gastric Cancer Cells Through Activating the NF-κB Pathway

    Ning Wu*, Changyu He, Bohui Zhu*, Jinling Jiang, Yiwen Chen*, Tao Ma

    Oncology Research, Vol.25, No.7, pp. 1153-1159, 2017, DOI:10.3727/096504017X14845839228545

    Abstract Gastric cancer (GC) is one of the most common cancers and the second leading cause of cancer deaths in the world. Many factors have been reported regarding the progression and development of GC. In this study, we aimed to investigate the correlation of 3-phosphoinositide dependent protein kinase-1 (PDK-1) with cell viability, migration, and invasion of GC. The expression of PDK-1 was measured in different GC cell lines. Thereafter, the expression of PDK-1 was interfered by small hairpin RNA (shRNA) and then incubated with or without the inhibitor of nuclear factor-kB (NF-kB) pyrrolidine dithiocarbamate (PDTC). We… More >

  • Open Access

    ARTICLE

    Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated According to Uridine Diphosphate Glucuronosyltransferase 1A1 Genotyping in Patients With Metastatic Colorectal Cancer

    Cheng-Jen Ma*†‡, Ching-Wen Huang*‡§, Yung-Sung Yeh*†¶, Hsiang-Lin Tsai*§#**, Huang-Ming Hu††‡‡, I-Chen Wu††‡‡, Tian-Lu Cheng§§¶¶, Jaw-Yuan Wang*†‡§**¶¶

    Oncology Research, Vol.25, No.5, pp. 673-679, 2017, DOI:10.3727/97818823455816X14786040691928

    Abstract We analyzed the results of previously treated patients with metastatic colorectal cancer (mCRC) who received regorafenib plus FOLFIRI with the irinotecan dose escalation on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping. Thirteen patients with previously treated mCRC were subjected to UGT1A1 genotyping between October 2013 and June 2015 and were administered regorafenib plus FOLFIRI with irinotecan dose escalation. Patients with UGT1A1*1/*1 and *1/*28 genotypes were administered 180 mg/m2 of irinotecan, whereas those with the UGT1A1*28/*28 genotype were administered 120 mg/m2 of irinotecan. For all patients, the irinotecan dose was increased by 30 mg/m2 every… More >

  • Open Access

    ARTICLE WITHDRAWN

    [ARTICLE WITHDRAWN] Upregulation of MicroRNA-935 Promotes the Malignant Behaviors of Pancreatic Carcinoma PANC-1 Cells via Targeting Inositol Polyphosphate 4-Phosphatase Type I Gene (INPP4A)

    Wang Cuiyue1, Feng Zhen2, Jiang Kaitong3, Zuo Xiuli1

    Oncology Research, Vol.25, No.4, pp. 559-569, 2017, DOI:10.3727/096504016X14759554689565

    Abstract THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020 More >

  • Open Access

    ARTICLE

    Three New Hydroxytetradecenals from Amomum tsao-ko with Protein Tyrosine Phosphatase 1B and Glycogen Phosphorylase Inhibitory Activity

    Xiaolu Qin1,3, Xinyu Li1,3, Yi Yang2, Mei Huang2, Shengli Wu1, Pianchou Gongpan1, Lianzhang Wu2, Juncai He2, Changan Geng1,3,*

    Phyton-International Journal of Experimental Botany, Vol.93, No.5, pp. 875-883, 2024, DOI:10.32604/phyton.2024.048192

    Abstract The fruits of Amomum tsao-ko (Cao-Guo) were documented in Chinese Pharmacopoeia for the treatment of abdominal pain, vomiting, and plague. In our previous study, a series of diarylheptanes and flavonoids with α-glucosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activity have been reported from the middle-polarity part of A. tsao-ko, whereas the antidiabetic potency of the low-polarity constituents is still unclear. In this study, three new hydroxytetradecenals, (2E, 4E, 8Z, 11Z)-6R-hydroxytetradeca-2,4,8,11-tetraenal (1), (2E, 4E, 8Z)-6R-hydroxytetradeca-2,4,8-trienal (2) and (2E, 4E)-6R-hydroxytetradeca-2,4-dienal (3) were obtained from the volatile oils of A. tsao-ko. The structures of compounds 1–3 were determined using spectroscopic data involving 1D and 2D nuclear magnetic More >

  • Open Access

    ARTICLE

    MicroRNA-338-3p Suppresses Proliferation of Human Liver Cancer Cells by Targeting SphK2

    Geqiong Xiao*, Qiong Wang*, Bo Li, Xiaohui Wu, Hui Liao*, Yili Ren*, Ning Ai†*

    Oncology Research, Vol.26, No.8, pp. 1183-1189, 2018, DOI:10.3727/096504018X15151495109394

    Abstract Recent studies have revealed abnormal expression of miRNAs in various tumors. Although microRNA-338-3p (miR-338-3p) plays an important role in many types of tumors, its influence on liver cancer (LC) is unknown. In this study, we found that expression of miR-338-3p was decreased in LC cells and tissues. Colony formation and cell proliferation were suppressed by enhanced expression of miR-338-3p in LC cells. Moreover, miR-338-3p targeted sphingosine kinase 2 (SphK2). Silencing of SphK2 had an identical influence as overexpression of miR-338-3p in LC cells. Overexpression of SphK2 without the 3'-untranslated region remarkably enhanced the growth suppression More >

  • Open Access

    ARTICLE

    Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway

    Xinlu Liu, Xiaodong Tan, Peng Liu, Yunhao Wu, Songying Qian, Xiaobo Zhang

    Oncology Research, Vol.26, No.7, pp. 1123-1131, 2018, DOI:10.3727/096504018X15166223632406

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors known, with an overall 5-year survival rate of less than 6% due to early local invasion and distant metastasis. Exploring suitable therapeutic targets associated with invasion and metastasis is required for improving the prognosis of PDAC. In this study, we investigated the role of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) in PDAC. PGAM1 expression was examined in tissue samples of 54 PDAC patients using immunohistochemistry, and the correlation between clinicopathological expression and PGAM1 expression was determined. A survival curve was generated using the… More >

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