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  • Open Access

    ARTICLE

    Screen for autophagy-related biomarkers in osteoarthritis based on bioinformatic analysis

    CHAO LIU*

    BIOCELL, Vol.48, No.2, pp. 339-351, 2024, DOI:10.32604/biocell.2023.047044

    Abstract Introduction: Osteoarthritis (OA) is still an important health problem, and understanding its pathological mechanisms is essential for its diagnosis and treatment. There is evidence that autophagy may play a role in OA progression, but the exact mechanism remains unclear. Methods: In this study, we adopted a multi-prong approach to systematically identify the key autophagy-related genes (ARGs) associated with OA. Through weighted gene co-expression network analysis, we initially identified significant gene modules associated with OA. Subsequent differential gene analysis performed on normal and OA specimens. Further analysis later using the MCC algorithm highlighted hub ARGs. These genes were then incorporated into… More >

  • Open Access

    ARTICLE

    Overexpression of RUNX1 mitigates dexamethasone-induced impairment of osteogenic differentiation and oxidative stress injury in bone marrow mesenchymal stem cells by promoting alpha-2 macroglobulin transcription

    QINGJIAN HE1, HUIXIN ZHU2,3, SHANHONG FANG4,5,*

    BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109

    Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression by kits, OD by alkaline… More >

  • Open Access

    ARTICLE

    M2 macrophages predicted the prognosis of breast cancer by combing a novel immune cell signature and promoted cell migration and invasion of cancer cells in vitro

    QI XIA1, XING CHEN2, QINGHUA MA3, XIANXIU WEN2,*

    BIOCELL, Vol.48, No.2, pp. 217-228, 2024, DOI:10.32604/biocell.2023.027414

    Abstract Background: Breast cancer (BC) is the most common cancer and the leading cause of cancer death in women. Immune features play an important role in improving the prognosis prediction of BC. However, while previous immune signatures consisted mainly of immune genes, immune cell-based signatures have been rarely reported. Methods: In this study, we report that a novel immune cell signature is effective in improving prognostic prediction by combining M2 macrophages. We identified 17 differentially infiltrating immune cells between cancer and normal groups. Prognostic features of the four immune cells identified by LASSO COX analysis showed good performance for survival risk… More >

  • Open Access

    ARTICLE

    Deep Learning Model for News Quality Evaluation Based on Explicit and Implicit Information

    Guohui Song1,2, Yongbin Wang1,*, Jianfei Li1, Hongbin Hu1

    Intelligent Automation & Soft Computing, Vol.38, No.3, pp. 275-295, 2023, DOI:10.32604/iasc.2023.041873

    Abstract Recommending high-quality news to users is vital in improving user stickiness and news platforms’ reputation. However, existing news quality evaluation methods, such as clickbait detection and popularity prediction, are challenging to reflect news quality comprehensively and concisely. This paper defines news quality as the ability of news articles to elicit clicks and comments from users, which represents whether the news article can attract widespread attention and discussion. Based on the above definition, this paper first presents a straightforward method to measure news quality based on the comments and clicks of news and defines four news quality indicators. Then, the dataset… More >

  • Open Access

    ARTICLE

    Driving Activity Classification Using Deep Residual Networks Based on Smart Glasses Sensors

    Narit Hnoohom1, Sakorn Mekruksavanich2, Anuchit Jitpattanakul3,4,*

    Intelligent Automation & Soft Computing, Vol.38, No.2, pp. 139-151, 2023, DOI:10.32604/iasc.2023.033940

    Abstract Accidents are still an issue in an intelligent transportation system, despite developments in self-driving technology (ITS). Drivers who engage in risky behavior account for more than half of all road accidents. As a result, reckless driving behaviour can cause congestion and delays. Computer vision and multimodal sensors have been used to study driving behaviour categorization to lessen this problem. Previous research has also collected and analyzed a wide range of data, including electroencephalography (EEG), electrooculography (EOG), and photographs of the driver’s face. On the other hand, driving a car is a complicated action that requires a wide range of body… More >

  • Open Access

    ARTICLE

    Gastric cancer secreted miR-214-3p inhibits the anti-angiogenesis effect of apatinib by suppressing ferroptosis in vascular endothelial cells

    WEIXUE WANG#, TONGTONG WANG#, YAN ZHANG, TING DENG, HAIYANG ZHANG*, YI BA*

    Oncology Research, Vol.32, No.3, pp. 489-502, 2024, DOI:10.32604/or.2023.046676

    Abstract Different from necrosis, apoptosis, autophagy and other forms of cell death, ferroptosis is a mechanism that catalyzes lipid peroxidation of polyunsaturated fatty acids under the action of iron divalent or lipoxygenase, leading to cell death. Apatinib is currently used in the third-line standard treatment of advanced gastric cancer, targeting the anti-angiogenesis pathway. However, Apatinib-mediated ferroptosis in vascular endothelial cells has not been reported yet. Tumor-secreted exosomes can be taken up into target cells to regulate tumor development, but the mechanism related to vascular endothelial cell ferroptosis has not yet been discovered. Here, we show that exosomes secreted by gastric cancer… More >

  • Open Access

    ARTICLE

    Low expression of fatty acid oxidation related gene ACADM indicates poor prognosis of renal clear cell carcinoma and is related to tumor immune infiltration

    JIECHUAN QIU1, TIANMIN YANG1, YANNING SUN2, KAI SUN2, YINGKUN XU3, QINGHUA XIA1,*

    Oncology Research, Vol.32, No.3, pp. 545-561, 2024, DOI:10.32604/or.2023.030462

    Abstract This research aims to identify the key fatty acid beta-oxidation (FAO) genes that are altered in kidney renal clear cell carcinoma (KIRC) and to analyze the role of these genes in KIRC. The Gene Expression Omnibus (GEO) and FAO datasets were used to identify these key genes. Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain (ACADM) between KIRC and non-cancer samples. The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features. The diagnostic performance of ACADM for KIRC was assessed using a diagnostic receiver… More >

  • Open Access

    RETRACTION

    Retraction: Psychological Support for Public-Funded Normal Students Engaged in Teaching Profession

    Shize Zhi1,2,*

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 81-81, 2024, DOI:10.32604/ijmhp.2024.049077

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Associations of Domain and Pattern of Sedentary Behaviors with Symptoms of Mental Disorders in Saudi Adults: ‘The Sedentary Behavior Paradox’

    Abdullah B. Alansare*

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 11-20, 2024, DOI:10.32604/ijmhp.2023.044656

    Abstract Emerging evidence suggests the existence of ‘paradoxical’ relationships between domain-specific sedentary behavior (SB) and health outcomes. This study assessed the associations of total and domain-specific SB, by pattern, with symptoms of mental disorders in Saudi adults. Participants (n = 554) completed a web-based survey between January 18th, 2023 and February 5th, 2023. Total SB was measured by using the Sedentary Behavior Questionnaire. Total SB was then partitioned into leisure, occupational, and commuting SB during weekdays and on weekend days. Symptoms of mental disorders including symptoms of depression, anxiety, and stress were evaluated by using the DASS-21 questionnaire. Adjusted linear regressions… More >

  • Open Access

    ARTICLE

    The Relationship between Father-Love Absence and Non-Suicidal Self-Injury: Based on Nock’s Integrated Theoretical Model of NSSI

    Yuhan Zhou1,2,#, Xiaojun Li3,#, Yanhui Xiang1,2,4,*

    International Journal of Mental Health Promotion, Vol.26, No.1, pp. 31-38, 2024, DOI:10.32604/ijmhp.2023.043167

    Abstract Fathers play an important role in children’s development throughout their lives, and Father-Love Absence (FLA) leads to more behavioral problems, including Non-Suicidal Self-Injury (NSSI). However, there has been no research on the relationship between FLA and NSSI and its influencing mechanism. This study is based on Nock’s integrated theoretical model of NSSI, aiming to explore the influence of FLA on NSSI and further investigate the mechanism of Subjective Vitality (SV) and Forgiveness (FORG). This study recruited 1795 adolescents in central China to complete four scales, including Father-Love Absence Scale (FLAS), The Subjective Vitality Scale (SVS), The Tendency to Forgive Scale… More >

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