PENG YANG1,*, ZHIYING ZOU1, XULING GAO2
BIOCELL, Vol.46, No.1, pp. 207-218, 2022, DOI:10.32604/biocell.2021.014728
Abstract Recent studies have shown that the microtubule disrupting protein Stathmin 1 (STMN1) is differentially
expressed in AML patients and healthy control. The aim of this study was to explore the effects and molecular
mechanism of STMN1 in AML. Here, the expression of STMN1 in peripheral blood cells (PBMCs) and bone marrow
of AML patients and healthy volunteers was detected by RT-PCR and Western blot. STMN1 expression was regulated
by transfected with STMN1 overexpressed plasmid or shRNA in two human leukemia cell lines K562 and HL60. Cell
proliferation was examined by CCK8 and Edu staining. Annexin V and TUNEL assays were… More >
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