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  • Open Access


    Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling


    BIOCELL, Vol.47, No.8, pp. 1793-1802, 2023, DOI:10.32604/biocell.2023.030093

    Abstract Background: Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human cancers. Patients often reduce the use of cisplatin due to its side effects, which in turn affects its treatment. This study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for chemotherapy. Methods: Primary human follicle dermal papilla cells (HFDPCs) were used as target cells for cisplatin-induced damage to hair cells. Western blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs damage. Cell survival and cell cycle were analyzed by mitochondrial staining reagent… More >

  • Open Access


    Safflower (Carthamus Tinctorius L.) a Potential Source of Drugs against Cryptococcal Infections, Malaria and Leishmaniasis

    Aknur Turgumbayeva1,2, Gulbaram Ustenova1, Ubaidilla Datkhayev1, Khairolla Rahimov3, Silvijus Abramavicius4,5, Agile Tunaityte4,*, Kairat Zhakipbekov1,6, Kaldanay Kozhanova1, Saken Tulemissov7, OzikhanUstenova8, Gulmira Datkayeva9, Edgaras Stankevicius1,10

    Phyton-International Journal of Experimental Botany, Vol.89, No.1, pp. 137-146, 2020, DOI:10.32604/phyton.2020.07665

    Abstract In this research we present that Carthamus Tinctorius L. (gen. Asteraceae, otherwise known as Safflower) (Fig. 1) may contain agents active in Cryptococcal infections, malaria and Leishmaniasis, as treatment options are becoming scarce due to drug resistance development. Phytochemistry and pharmacological activities (antimicrobial, antimalarial, antileishmanial) of C. tinctorius L. were analyzed. The composition of volatile oil of safflower dried flowers was analyzed by gas chromatography-mass spectrophotometry with flame ionization detector (GC-FID) and in vitro sensitivity assays were performed to assess biological activity. 8 known and 3 unknown compounds were detected in the extract (Fig. 1). Then the Safflower ointment was… More >

  • Open Access


    Fruit development of two high oleic safflower (Carthamus tinctorius L.) cultivars

    Franchini MC1, AC F lemmer1, LI Lindström1, MA David2, PA Fernandez3

    Phyton-International Journal of Experimental Botany, Vol.83, pp. 379-388, 2014, DOI:10.32604/phyton.2014.83.379

    Abstract The purpose of this study was to describe fruit development in two high oleic safflower (Carthamus tinctorius L.) cultivars during four growing seasons. Pericarp histogenesis, and dynamics of pericarp and seed dry weight and fruit water content were studied. The dynamics of the pericarp and seed growth was similar between cultivars and years. The pericarp completed its growth before the seed. Pericarp potential size was already set at anthesis as no cell division was observed at this time. Maximum pericarp dry weight was achieved 8 days after anthesis, when cell wall lignification concluded. At this time, twinned prismatic simetric crystals… More >

  • Open Access


    Yield and stability of safflower varieties (Carthamus tinctorius L.) in the Semiarid Pampean Region

    Mirassón HR1, IR Palomo2, RE Brevedan2, MN Fioretti2

    Phyton-International Journal of Experimental Botany, Vol.80, pp. 147-151, 2011, DOI:10.32604/phyton.2011.80.147

    Abstract Safflower production is mainly concentrated in northwestern Argentina although the most suitable area for its production is the central, Semiarid Pampean Region. The response of different varieties able to produce high sustainable yields was studied under different environments, with the idea of promoting these varieties in the study region. Six variety trials were carried out at two locations in the study area, Santa Rosa (La Pampa, 36° 39’ S, 64° 16’ W) and Tres Picos (Buenos Aires, 38° 16’ S, 62° 13’ W), during several years. Relative yield was used as a measure of safflower stability. Varieties S-541, S-200 and… More >

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