PRABHAT KUMAR, ANJANA SARKAR, PURNIMA JAIN^*

Journal of Polymer Materials, Vol.39, No.1-2, pp. 121-135, 2022, DOI:10.32381/JPM.2022.39.1-2.8

Abstract Biocompatible graphene derivative materials (GBMs) to harness the maximum potential of pristine graphene biologically, is the most important strategy for its advanced applications in pharmaceutical and other biomedical fields. Currently, scientists are trying to find this by using biopolymer nanocomposites or anchored materials. Nevertheless, tuning the bare GBMs towards biocompatibility is a beautiful approach to exploit the fundamental potential of pristine graphene vis-à-vis suppressing the effects of incorporated biopolymers or anchored materials. Herein, a large-scale, cost-effective, facile, and environment-friendly green synthetic strategy is used for the synthesis of reduced graphene oxide (rGO) nanosheet using L-ascorbic acid (L-AA) as a reducing/stabilizing/capping… More >

Kalaivani Muniandy¹, Zuhaida Asra Ahmad^1,4, Sylvia Annabel Dass¹, Shaharum Shamsuddin², Nethia Mohana Kumaran³, Venugopal Balakrishnan^1,*

Oncologie, Vol.23, No.2, pp. 279-291, 2021, DOI:10.32604/Oncologie.2021.015969

Abstract Spheroids are generally self-assembled cells with the ability to generate their extracellular matrix, including the complex cell-matrix and the cell-cell interactions that resemble the functional characteristics of the corresponding tissue in vivo. The study aimed to develop a three-dimensional (3D) spheroid system for the cervical cancer cell lines, HeLa (HPV18), CaSki (HPV16), SiHa (HPV16), C33A (non-HPV), HT3 (non-HPV) as well as to identify its biological activity in the extracellular form. For the formation of the cervical cancer spheroids, the liquid overlay approach was applied, followed by embedding to the bovine collagen I matrix. Spheroid formation using the liquid overlay approach… More >