YI ZHENG#, PENGFEI ZHANG#, JINSHENG ZHU#, LINGKAI ZHANG, WENXIAN ZENG*
BIOCELL, Vol.44, No.2, pp. 201-207, 2020, DOI:10.32604/biocell.2020.08770
Abstract Spermatogenesis is a highly efficient and intricate process in the testis by which mature spermatozoa are
produced daily to maintain lifelong male fertility. Essential to this process are spermatogonia capable of both
proliferation and differentiation. Nevertheless, the underlying mechanisms for spermatogonial proliferation and
differentiation remain poorly understood. MicroRNAs (miRNAs) are a category of non-coding small RNAs with
regulatory functions by binding to the 3’ untranslated region (UTR) of the target mRNA. Previous studies have
demonstrated that miRNAs are capable of modulating cell proliferation, differentiation and apoptosis, but the roles of
individual miRNAs in spermatogonial fate determination remain largely elusive. Here,… More >
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