Ching-Wen Huang*, Cheng-Jen Ma*†, Wei-Chih Su*, Yi-Ting Chen‡§, Hsiang-Lin Tsai*¶, Yung-Sung Yeh*#,
Tsung-Kun Chang*, Wen-Hung Hsu**††, Fang-Jung Yu**††, Jaw-Yuan Wang*¶‡‡§§¶¶##
Oncology Research, Vol.28, No.7-8, pp. 701-714, 2020, DOI:10.3727/096504020X15986099915822
Abstract This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in
patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression.
We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen adjuvant
chemotherapy. The clinicopathological features and effects of metronomic maintenance therapy with oral capecitabine (daily dose of 850 mg/m2
, twice daily, on days 1–14 every 3 weeks for 6 months) on survival according to
treatment group and EGFR expression were analyzed. By conducting an in vitro cell line study and in vivo study
through… More >
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