Hyun-Jung Moon,1
So-Young Park,1
Su-Hoon Lee, Chi-Dug Kang, Sun-Hee Kim
Oncology Research, Vol.27, No.7, pp. 835-847, 2019, DOI:10.3727/096504019X15517850319579
Abstract Recently, novel therapeutic strategies have been designed with the aim of killing cancer stem-like cells (CSCs),
and considerable interest has been generated in the development of specific therapies that target stemnessrelated marker of CSCs. In this study, nonsteroidal anti-inflammatory drugs (NSAIDs) significantly potentiated Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG)-mediated cytotoxicity through
apoptotic and autophagic cell death induction, but COX-2-inhibitory function was not required for NSAIDinduced autophagy in CD44-overexpressing human chronic myeloid leukemia K562 (CD44highK562) cells.
Importantly, we found that treatment with NSAIDs resulted in a dose-dependent increase in LC3-II level and
decrease in p62 level and simultaneous reduction in multiple stemness-related markers… More >
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