H.R. CONTRERAS1, V. PAREDES1, B. URQUIETA2, L. DEL VALLE4, E. BUSTOS-OBREGÓN3
BIOCELL, Vol.30, No.3, pp. 423-429, 2006, DOI:10.32604/biocell.2006.30.423
Abstract Parathion® is an organophosphorate pesticide amply used in agriculture. Many alterations induced by organophosphorate pesticides have been described, such as: cytogenetic alterations in germinal cells, oligozoospermia and teratozoospermia in the mouse. The effect of Parathion®, both pure (PP) and commercial (PC), on mouse interstitial cell testosterone production was evaluated in vivo and in vitro. Male mice were intraperitoneally injected with a single dose of 1/3 LD50 of Parathion®, both PP and PC. The animals were sacrificed at 1, 8 and 40 days post injection to evaluate the impact of disrupting testosterone production on spermatogonia, spermatocytes and elongated spermatids. The plasma… More >
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