YUAN BI1,2,#, TIANQI LI2,#, HONGJIE PAN2, MING GUO2, LIANGKANG CHEN2, QI QI1, MEIXIN ZHANG2, LINGLING ZHANG2, LININ YU2, XIAOFENG WAN2, HUAJUN ZHENG2,*, RUNSHENG LI2,*
BIOCELL, Vol.44, No.3, pp. 301-313, 2020, DOI:10.32604/biocell.2020.011208
Abstract Elemental sulfur has been used as a traditional Chinese medicine to treat the late-onset hypogonadism and
impotence without a clarified mechanism for many hundreds of years. In the present study, mice were received sulfur
or distilled water for 35 days by daily intragastric gavage at a dose of 250 mg/kg body weight. Then, the serum
testosterone level and genes associated with testicular testosterone biosynthesis (TTB) were detected. The gut
microbiota was also analyzed by 16S rRNA gene sequencing. Serum testosterone level was significantly increased by
291.1% in sulfur-treated mice. The H2S levels in serum and feces were significantly increased. The… More >
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