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  • Open Access

    ARTICLE

    Suppression of Dry-Coupled Rubber Layer Interference in Ultrasonic Thickness Measurement: A Comparative Study of Empirical Mode Decomposition Variants

    Weichen Wang1, Shaofeng Wang1, Wenjing Liu1,*, Luncai Zhou2, Erqing Zhang1, Ting Gao3, Grigory Petrishin4

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071278 - 08 January 2026

    Abstract In dry-coupled ultrasonic thickness measurement, thick rubber layers introduce high-amplitude parasitic echoes that obscure defect signals and degrade thickness accuracy. Existing methods struggle to resolve overlap-ping echoes under variable coupling conditions and non-stationary noise. This study proposes a novel dual-criterion framework integrating energy contribution and statistical impulsivity metrics to isolate specimen re-flections from coupling-layer interference. By decomposing A-scan signals into Intrinsic Mode Functions (IMFs), the framework employs energy contribution thresholds (>85%) and kurtosis indices (>3) to autonomously select IMFs containing valid specimen echoes. Hybrid time-frequency thresholding further suppresses interference through amplitude filtering and spectral focusing. More >

  • Open Access

    ARTICLE

    3,9-Di-O-Methylnissolin Inhibits Gastric Cancer Progression by the RIPK2-Mediated Suppression of the NF-κB Pathway

    Yun Zhou1,2, Shixiong Liu1,2, Ya Zheng1,3,4, Yuping Wang1,3,4,*, Yongning Zhou1,3,4,*

    BIOCELL, Vol.49, No.10, pp. 1967-1983, 2025, DOI:10.32604/biocell.2025.069869 - 22 October 2025

    Abstract Background: Gastric cancer (GC) is a prevalent cause of death. 3,9-Di-O-methylnissolin (DOM) is a flavonoid isolated from Astragalus membranaceus. It has anticancer and anti-inflammatory effects, but its effect and mechanism of action on GC are not very clear. Methods: The appropriate concentration was selected after observing the effects of varying concentrations of DOM on the viability of GC cells, which was examined through the cell counting kit-8 (CCK-8) assay. The receptor-interacting protein kinase 2 (RIPK2) overexpression plasmid was transfected into GC cells, which were then treated with DOM. Cell cycle and proliferation, RIPK2 levels, and inflammatory… More > Graphic Abstract

    3,9-Di-O-Methylnissolin Inhibits Gastric Cancer Progression by the RIPK2-Mediated Suppression of the NF-κB Pathway

  • Open Access

    ARTICLE

    Intrathecal Pemetrexed Administration and Myelosuppression in Patients with Leptomeningeal Metastases from Lung Adenocarcinoma: A Retrospective Study

    Junxing Chen1,#, Luping Pan1,#, Yunzhi Liu1,2, Yan Fang1, Ruoxuan Li1, Zhiqin Lu1,3, Anwen Liu1,4, Yanqing He5,*, Zhimin Zeng1,6,*

    Oncology Research, Vol.33, No.8, pp. 2107-2121, 2025, DOI:10.32604/or.2025.064237 - 18 July 2025

    Abstract Background: Non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) have a very poor prognosis. Intrathecal pemetrexed (IP) has shown moderate efficacy in treating patients with NSCLC-LM. Myelosuppression is the most common adverse effect following IP administration. Despite this trend, the specific risk factors contributing to IP-related myelosuppression remain unclear. Methods: This study conducted a retrospective analysis of lung adenocarcinoma (LUAD) patients with LM who received IP treatment at the Second Affiliated Hospital of Nanchang University from April 2017 to April 2024. Risk factors for myelosuppression were identified through univariate and multivariate logistic regression… More >

  • Open Access

    ARTICLE

    Experimental Study of a Helium Sorption Cooler with Low Temperature Fluctuation and Long Hold Time below 1 K

    Tianshuo Liu1,2, Xiaoyu Cui1, Lihao Lu2,3, Kongkuai Ying2,*, Yang Wang2,3, Kangjun Liu2, Zilong Wang1, Zhenhua Jiang2,3, Shaoshuai Liu2,3,*

    Frontiers in Heat and Mass Transfer, Vol.23, No.3, pp. 739-750, 2025, DOI:10.32604/fhmt.2025.064532 - 30 June 2025

    Abstract Helium sorption cooler technology is a key means to realize highly reliable low-vibration very low-temperature environments, which have important applications in fields such as quantum computing and space exploration. The laboratory designed a superfluid suppression small hole and a multi-ribbed condenser, developed a reliable-performance helium sorption cooler (HSC), and conducted experimental studies. Experimental results show that the prototype can achieve the lowest cooling temperature of 873 mK without load by filling 6 MPa helium at room temperature. The low-temperature hold time is 26 h, and the temperature fluctuation is within 0.8 mK. The cooling power More >

  • Open Access

    ARTICLE

    Social desirability response bias confounds the effect of gender on social media addiction

    Lihua Zuo1,2,#, Jian Mao2,#,*

    Journal of Psychology in Africa, Vol.35, No.2, pp. 241-247, 2025, DOI:10.32604/jpa.2025.065765 - 30 June 2025

    Abstract This study examined how social desirability responses confound the relationship between gender and social media addiction. A total of 496 college student social media users (females = 310, 62.5%, mean age = 20.15, SD = 1.26) completed an online questionnaire on Social Media Addiction and Social Desirability. Mediation analysis revealed that females were at higher risk for social media addiction. On the other hand, the indirect effect of gender on social media addiction via social desirability is associated with lower social media addiction, which suggests that social desirability had a suppression effect on social media More >

  • Open Access

    ARTICLE

    A Pedestrian Sensitive Training Algorithm for False Positives Suppression in Two-Stage CNN Detection Methods

    Qiang Guo1,2,*, Rubo Zhang1, Bingbing Zhang3

    CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1307-1327, 2025, DOI:10.32604/cmc.2025.063288 - 09 June 2025

    Abstract Pedestrian detection has been a hot spot in computer vision over the past decades due to the wide spectrum of promising applications, and the major challenge is false positives that occur during pedestrian detection. The emergence of various Convolutional Neural Network-based detection strategies substantially enhances pedestrian detection accuracy but still does not solve this problem well. This paper deeply analyzes the detection framework of the two-stage CNN detection methods and finds out false positives in detection results are due to its training strategy misclassifying some false proposals, thus weakening the classification capability of the following… More >

  • Open Access

    ARTICLE

    Characterization of Transcription Factor Krüppel-Like Factor 3 Expression in Splenic T Lymphocytes and Association with Immune Status in Septic Mice

    MIAO YAN1, DONGXUAN CHI2, WEN WANG3, PEI PEI4, MIN XIE1, SHUANGLING LI1,*

    BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025

    Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >

  • Open Access

    ARTICLE

    Solitude capacity and emotional experience in Chinese college students: The suppression effect of emotion regulation

    Youming Song*, Yuxin Li, Yin Wang, Yuan Xie, Gang Qiao, Jingyi Chen

    Journal of Psychology in Africa, Vol.35, No.1, pp. 51-59, 2025, DOI:10.32604/jpa.2025.065781 - 30 April 2025

    Abstract Although numerous findings show that people experience both positive and negative experiences with regards to solitude, the relationship between solitude capacity and emotional experience remains unclear. The current study investigated the extent to which emotion regulation may play a suppressive role in the relationship between solitude capacity and emotional experience. Questionnaires on solitude capacity, emotion regulation, and emotional experience were completed by a sample of Chinese college students (n = 844; 432 females; Meanage = 19.79 years, SD = 1.43 years). The results of the indirect effect test showed that cognitive reappraisal suppresses the prediction of solitude More >

  • Open Access

    RETRACTION

    Retraction: Overexpression of long noncoding RNA PTENP1 inhibits cell proliferation and migration via suppression of miR-19b in breast cancer cells

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.4, pp. 989-989, 2025, DOI:10.32604/or.2024.056912 - 19 March 2025

    Abstract This article has no abstract. More >

  • Open Access

    COMMENTARY

    A Commentary on RIPK2: The Hidden Driver of MHC-I Related Immune Suppression in Cancer

    Qian Yang, Alina Leonie Ruff, Lydia Meder*

    BIOCELL, Vol.49, No.2, pp. 161-165, 2025, DOI:10.32604/biocell.2025.060227 - 28 February 2025

    Abstract This article has no abstract. More >

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