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  • Open Access

    ARTICLE

    Overexpression of Long Noncoding RNA PTENP1 Inhibits Cell Proliferation and Migration via Suppression of miR-19b in Breast Cancer Cells

    Xianbiao Shi, Xiaoqiao Tang, Lei Su

    Oncology Research, Vol.26, No.6, pp. 869-878, 2018, DOI:10.3727/096504017X15123838050075

    Abstract This study aimed to investigate the effect of long noncoding RNA PTENP1 in the development of breast cancer (BC). Quantitative real-time PCR was utilized to determine the expression of PTENP1 in tissues and cell lines. pcDNA3.1 and shRNA were used to over- and low-express PTENP1 in BC cell lines, and miR-19b mimic and inhibitor were utilized to over- and low-express miR-19b. Then the abilities of cell survival, apoptosis, migration, and invasion were assessed in BC cells with different expression levels of PTENP1 and miR-19b. The expression of PTENP1 was significantly downregulated in both BC tissues More >

  • Open Access

    ARTICLE

    miR-644a Inhibits Cellular Proliferation and Invasion via Suppression of CtBP1 in Gastric Cancer Cells

    Yingchao Li*, Xiaoni Yan*, Li Ren*, Yang Li

    Oncology Research, Vol.26, No.1, pp. 1-8, 2018, DOI:10.3727/096504016X14772410356982

    Abstract Epithelial–mesenchymal transition (EMT) is one of the most important mechanisms in the metastasis of various cancers, including gastric cancer (GC). In this study, we explored the putative significance of miR-644a and its role in EMT-mediated metastasis of GC. We first detected the expression of miR-644a in a cohort of 107 GC tissues using quantitative RT-PCR. The expression of miR-644a was suppressed in GC tissues and was associated with a later clinical stage and tumor metastasis. Restoring the expression of miR-644a could significantly suppress the migration and invasion of HGC-27 and SGC-7901 cells, which might be More >

  • Open Access

    ARTICLE

    Research on the Generation Mechanism and Suppression Method of Aerodynamic Noise in Expansion Cavity Based on Hybrid Method

    Haitao Liu1,2,*, Jiaming Wang1, Xiuliang Zhang1, Yanji Jiang2, Qian Xiao1

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 2747-2772, 2024, DOI:10.32604/cmes.2024.047129

    Abstract The expansion chamber serves as the primary silencing structure within the exhaust pipeline. However, it can also act as a sound-emitting structure when subjected to airflow. This article presents a hybrid method for numerically simulating and analyzing the unsteady flow and aerodynamic noise in an expansion chamber under the influence of airflow. A fluid simulation model is established, utilizing the Large Eddy Simulation (LES) method to calculate the unsteady flow within the expansion chamber. The simulation results effectively capture the development and changes of the unsteady flow and vorticity inside the cavity, exhibiting a high… More > Graphic Abstract

    Research on the Generation Mechanism and Suppression Method of Aerodynamic Noise in Expansion Cavity Based on Hybrid Method

  • Open Access

    ARTICLE

    Suppression of cell pyroptosis by omeprazole through PDE4-mediated autophagy in gastric epithelial cells

    LIPING YE1,2,3,#, HUIYAN SUN4,#, XINHUA LIANG2,#, WENXU PAN2, LI XIANG2,3, WENJUN DU2, LANLAN GENG2, WANFU XU2,3,*, SITANG GONG1,2,3,*

    BIOCELL, Vol.47, No.12, pp. 2709-2719, 2023, DOI:10.32604/biocell.2023.044295

    Abstract Introduction: Helicobacter pylori is a risk factor for the development of peptic ulcers with autophagy dysfunction. Omeprazole was widely known as the first-line regimen for H. pylori-associated gastritis. Objectives: The objective of this work was to assess the role of omeprazole on cell pyroptosis and autophagy. Methods: The clinical samples were collected. Quantitative polymerase chain reaction, western blotting, enzyme linked immunosorbent assay, and immunofluorescence (IF) analysis were conducted to reveal the mechanism of omeprazole on cell pyroptosis and autophagy. Results: The results revealed that omeprazole could decrease cell pyroptosis, which was attributed to the downregulation of cleaved caspase-1 expression,… More >

  • Open Access

    ARTICLE

    Research on Stick-Slip Vibration Suppression Method of Drill String Based on Machine Learning Optimization

    Kanhua Su, Jian Wei*, Meng Li, Hao Li, Wenghao Da, Lang Zhang

    Sound & Vibration, Vol.57, pp. 97-117, 2023, DOI:10.32604/sv.2023.043734

    Abstract During the drilling process, stick-slip vibration of the drill string is mainly caused by the nonlinear friction generated by the contact between the drill bit and the rock. To eliminate the fatigue wear of downhole drilling tools caused by stick-slip vibrations, the Fractional-Order Proportional-Integral-Derivative (FOPID) controller is used to suppress stick-slip vibrations in the drill string. Although the FOPID controller can effectively suppress the drill string stick-slip vibration, its structure is flexible and parameter setting is complicated, so it needs to use the corresponding machine learning algorithm for parameter optimization. Based on the principle of… More > Graphic Abstract

    Research on Stick-Slip Vibration Suppression Method of Drill String Based on Machine Learning Optimization

  • Open Access

    ARTICLE

    Analysis of Sub-Synchronous Oscillation of Virtual Synchronous Generator and Research on Suppression Strategy in Weak Grid

    Chongyang Zhao, Wei Chai, Beibei Rui, Lin Chen*

    Energy Engineering, Vol.120, No.11, pp. 2683-2705, 2023, DOI:10.32604/ee.2023.029620

    Abstract At present, the direct drive permanent magnet synchronous generator (DD-PMSG) grid connected system based on virtual synchronous generator (VSG) control will experience power oscillation at sub synchronous frequencies. The mechanism and characteristics of this new type of sub-synchronous interaction (SSI) are not yet clear, and the system cannot recover to steady state solely based on the characteristics of VSG itself. Especially when connected to a weak current network, oscillations are more pronounced, affecting the stability of the system. In severe cases, the system may trigger shutdown protection and be disconnected from the network. Existing research More >

  • Open Access

    ARTICLE

    Scutellarin alleviates complete freund’s adjuvant-induced rheumatoid arthritis in mice by regulating the Keap1/Nrf2/HO-1 pathway

    JIAN LI1, QINGQING WANG2, XIAOYING ZHANG1,*

    BIOCELL, Vol.47, No.6, pp. 1307-1316, 2023, DOI:10.32604/biocell.2023.028714

    Abstract Scutellarin (SCU) is a herbal flavonoid glucuronide with multiple pharmacological activities, including anti-oxidant, anti-inflammation, vascular relaxation, anti-platelet, and myocardial protection. However, the effect of SCU on complete Freund’s adjuvant (CFA)-induced rheumatoid arthritis (RA) had not been studied. In this study, we investigated the beneficial effects of SCU in the CFA-induced RA mice model and the anti-arthritic activity was evaluated by paw edema. Enzyme-linked immunosorbent assay (ELISA) was carried out to evaluate the plasma levels of immunoglobulin (Ig)G, IgE, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, receptor activator of nuclear factor-κB ligand (RANKL), and osteoprotegerin (OPG).… More >

  • Open Access

    ARTICLE

    LITHIUM-ION BATTERY FIRE SUPPRESSION USING WATER MIST SYSTEMS

    Matt Ghijia,*, Ian Burchb, Brigitta Suendermannb, Grant Gambleb, Vasily Novozhilov a, Paul Josepha, Khalid Moinuddina

    Frontiers in Heat and Mass Transfer, Vol.17, pp. 1-8, 2021, DOI:10.5098/hmt.17.13

    Abstract Lithium-ion batteries (LiBs) have superior energy density and lifetime compared to battery technologies such as lead acid. Despite the widespread application of LiBs in energy storage systems, electronic devices, aerospace and the automotive industry, they present a fire risk. In this study, experiments were conducted to characterize the thermal behavior of the electrolyte (as the main contributor to LiB fires) using a cone calorimeter; investigate the interactions of water mist and a Bunsen burner, as a precursor to examining the effectiveness of a water mist suppression system in extinguishing a LiB fire. In the present… More >

  • Open Access

    ARTICLE

    Harmonic State-Space Based AC-Side Impedance Model of MMC and High Frequency Oscillation Characteristics Analysis

    Hui Fang1, Jingsen Zhou1, Haozheng Wang2,*, Yanxu Wang2, Hongji Xiang1, Yechun Xin2

    Energy Engineering, Vol.120, No.4, pp. 831-850, 2023, DOI:10.32604/ee.2023.025171

    Abstract Recently, high-frequency oscillation of the modular multilevel converter (MMC) based high-voltage direct current (HVDC) projects has attracted great attentions. In order to analyze the small-signal stability, this paper uses the harmonic state-space (HSS) method to establish a detailed frequency domain impedance model of the AC-side of the HVDC transmission system, which considers the internal dynamic characteristics. In addition, the suggested model is also used to assess the system's high-frequency oscillation mechanism, and the effects of the MMC current inner loop control, feedforward voltage links, and control delay on the high-frequency impedance characteristics and the effect More >

  • Open Access

    ARTICLE

    Real-Time Speech Enhancement Based on Convolutional Recurrent Neural Network

    S. Girirajan, A. Pandian*

    Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 1987-2001, 2023, DOI:10.32604/iasc.2023.028090

    Abstract Speech enhancement is the task of taking a noisy speech input and producing an enhanced speech output. In recent years, the need for speech enhancement has been increased due to challenges that occurred in various applications such as hearing aids, Automatic Speech Recognition (ASR), and mobile speech communication systems. Most of the Speech Enhancement research work has been carried out for English, Chinese, and other European languages. Only a few research works involve speech enhancement in Indian regional Languages. In this paper, we propose a two-fold architecture to perform speech enhancement for Tamil speech signal… More >

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