Hsing-Ju Wu^1,2, Yu-Chieh Tsai^3,*, Hung-Yu Lin^2,4,*

European Cytokine Network, Vol.37, No.2, pp. 121-135, 2026, DOI:10.32604/ecn.2026.079012 - 30 June 2026

Abstract Backgrounds: Lymph node metastasis is a critical determinant of breast cancer prognosis, yet the specific microenvironmental cytokines driving this process remain elusive. This study aims to identify key prognostic cytokines linking nodal metastasis to tumor microenvironment (TME) remodeling and to evaluate their clinical utility. Methods: A predefined panel of 176 microenvironmental genes was evaluated using differential expression analysis and the Least Absolute Shrinkage and Selection Operator (LASSO) algorithm on the TCGA-BRCA cohort to identify optimal predictors of nodal metastasis. Prognostic value was assessed via Kaplan-Meier, subgroup, and multivariate Cox regression analyses, and validated across five… More > Graphic Abstract

Lihao Lu^1,2, Yan Lu^1,2, Zhenhua Jiang^1,2, Shaoshuai Liu^1,2,*, Yinong Wu^1,2

Frontiers in Heat and Mass Transfer, Vol.24, No.3, 2026, DOI:10.32604/fhmt.2026.080328 - 29 June 2026

Abstract Sub-Kelvin cooling technology is a critical prerequisite for high-sensitivity detection in deep space exploration and quantum computing. Operating identical sorption coolers in parallel is a common engineering approach to enhance cooling capacity and extend hold time for these cryogenic platforms. However, this study reports an unexpected “symmetry breaking” phenomenon observed in a parallel Helium-4 sorption cooling system where the cold heads are connected via Oxygen-Free High Thermal Conductivity (OFHC) copper linkages. Instead of the expected uniform load sharing, the system spontaneously evolves into an asymmetric “quasi-series” operational mode. In this state, one cooler preferentially consumes… More >

Bo Liu, Xue Li^*

BIOCELL, Vol.50, No.7, 2026, DOI:10.32604/biocell.2026.077797 - 29 June 2026

Abstract Background: As a key glycolytic enzyme, Pyruvate kinase M2 (PKM2), which is highly expressed in cancer cells, promotes hepatocellular carcinoma (HCC) proliferation/metastasis. This research investigates the involvement of Ubiquitin protein ligase E3 component N-recognin 7 (UBR7) in HCC progression/glycolysis and its potential mechanisms. Methods: UBR7 expressions in HHL-5, Huh-7, and HepG2 cells were investigated using Quantitative Reverse Transcription Polymerase Chain Reaction and Western Blot. Cell counting kit-8, clone formation experiment, scratch-wound assay, and transwell testing were conducted to assess the malignant biological behaviors of HepG2 and Huh-7 cells; the absorption level of glucose and generation levels… More >

Meng Zhang¹, Lijuan Zhang², Jie Zhang¹, Shiliang Miao², Jiangong Yang², Yajun Zhao^1,*, Feifei Bu¹

Energy Engineering, Vol.123, No.7, 2026, DOI:10.32604/ee.2025.074465 - 18 June 2026

Abstract Conventional electric servo drive systems suffer from high common-mode voltage (CMV) due to the use of zero vectors in Space Vector Pulse Width Modulation (SVPWM). To mitigate this issue, this paper proposes an inverted SVPWM (I-SVPWM) strategy. By simply inverting the switching actions of a specific phase, this strategy avoids the use of zero vectors and achieves an effect similar to Active Zero-State PWM (AZSPWM), thereby effectively suppressing common-mode voltage. Compared with AZSPWM, the proposed method eliminates the need to recalculate vector action times or design new switching sequences. It can be seamlessly implemented by… More > Graphic Abstract

Pengtao Hu¹, Junjie Sun¹, Jian Lu², Chunlei Ge³, Hanzhi Sun¹, Chengyu Lv^1,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.076013 - 22 April 2026

Abstract Liver metastases from colorectal cancer (CRC) are a primary cause of poor patient prognosis, closely linked to the liver’s unique tumor microenvironment (TME). Compared to primary tumors, research on the TME of liver metastases remains insufficient. This review systematically summarizes recent advances in TME research concerning colorectal liver metastases (CRLM), emphasizing its organ-specific characteristics, pivotal role in tumor progression, and influence on treatment response. We delve into the intricate cellular components of the TME—including tumor-associated macrophages, cancer-associated fibroblasts, and myeloid-derived suppressor cells—and non-cellular constituents such as the extracellular matrix and soluble factors. Furthermore, we explore More >

Yan Zhu^1,#, Bin Guan^1,#, Wencai Guan¹, Jihong Zhang¹, Shiyu Wang¹, Jimin Shi¹, Wei Fan¹, Qi Lu^2,3, Lingyun Zhang^4,5,*, Guoxiong Xu^1,2,*

Oncology Research, Vol.34, No.5, 2026, DOI:10.32604/or.2026.075241 - 22 April 2026

Abstract Background: Ovarian cancer poses the greatest threat to survival among gynecologic cancers in women. Long non-coding RNAs (lncRNAs) have emerged as critical regulators in oncogenesis. The current study aimed to elucidate the function and regulatory mechanism of lncRNA KRT7-AS in ovarian cancer. Methods: The clinical significance of KRT7-AS was evaluated through bioinformatics analysis of data from public repositories. KRT7-AS expression was examined by RT-qPCR and fluorescence in situ hybridization. The function analyses were conducted using assays for cell proliferation, migration, invasion, wound healing, and colony formation. Assessment of cell cycle and apoptosis was performed using flow… More >

Bakhtawar Gul¹, Atif Elahi^1,2, Tahir Saleem³, Noor Gul¹, Fahad Algarni⁴, Insaf Ullah^5,*

CMC-Computers, Materials & Continua, Vol.87, No.2, 2026, DOI:10.32604/cmc.2026.069776 - 12 March 2026

Abstract Orthogonal Frequency Division Multiplexing (OFDM) enables efficient Dynamic Spectrum Access (DSA) but suffers from high sidelobe that causes excessive out-of-band (OOB) emissions and expose the system to spectrum-layer cyberattacks such as man-in-the-middle (MITM), eavesdropping, and primary user emulation (PUE) attacks. To address both spectral leakage and its security implications, this paper introduces a secure and intelligent hybrid optimization strategy that combinesan Eigenspace-based Generalized Sidelobe Canceller (ES-GSC) with a Genetic Algorithm (GA), to derive optimally weighted cancellation carriers. The proposed method jointly suppresses sidelobes and reinforces resistance to leakage-based attacks. MATLAB Simulation demonstrate considerable reductions in More >

Chaoyu Wei¹, Haipeng Zhang¹, Weidong Shi^1,*, Yongfei Yang^1,*, Linwei Tan¹, Xianglong Wu², Yurui Dai¹

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.2, 2026, DOI:10.32604/fdmp.2026.074543 - 04 March 2026

Abstract During high-speed operation, mixed-flow pumps are susceptible to cavitation, which destabilizes the internal flow, increases energy losses, and degrades hydraulic efficiency. To assess the effectiveness of blade perforation as a cavitation-mitigation strategy, in this study several mixed-flow pump models incorporating perforations were developed. Numerical simulations were performed for configurations with circular holes positioned at different locations along the blade leading edge, and the computational results were validated against experimental measurements. The findings indicate that the location of the perforations plays a decisive role in cavitation suppression. Moving from the blade rim toward the hub along More >

Pingping Hu^1,2,#, Zhenhao Fei^1,2,#, Jianhua Bai^1,2, Zhiwen Wang^1,2, Yun Jin^1,2,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.070207 - 24 February 2026

Abstract Objectives: Pancreatic cancer (PC) is characterized by poor prognosis due to its limited treatment choices and delayed detection. S100A14 has been implicated in tumor progression, yet its regulatory hierarchy and functional interplay in PC remain unclear. This study aimed to define the role of S100A14 in PC progression. Methods: Integrated bioinformatic analyses of TCGA-PAAD and GSE22780 datasets identified candidate hub genes. Prognostic relevance was assessed via Kaplan-Meier and ROC analyses. Functional experiments were performed in PANC-1 and BxPC-3 cells, including qRT-PCR, CCK-8 assay, Western blotting, Transwell assay, and apoptosis assay. Co-immunoprecipitation (Co-IP) was used to verify… More >

Dmytro A. Kiriziy¹, Oksana V. Dubrovna¹, Oksana G. Sokolovska-Sergiienko¹, Alina S. Holoboroda¹, Victor V. Rohach^1,2, Oleg O. Stasik^1,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.075371 - 30 January 2026

Abstract Water scarcity severely constrains the genetic potential of wheat yield worldwide. Proline is among the most versatile stress-related metabolites in plants, and targeting genes involved in proline synthesis and degradation represents a promising strategy for developing drought-tolerant wheat genotypes. This study evaluates the performance of the photosynthetic apparatus in transgenic wheat line with RNAi-mediated suppression of proline dehydrogenase (ProDH) and in the original (wild-type) genotype, under both drought and recovery conditions. Drought was induced at the flowering stage by lowering soil moisture to 30% field capacity for 7 days, compared with 70% field capacity in… More >