Yun Zhou^1,2, Shixiong Liu^1,2, Ya Zheng^1,3,4, Yuping Wang^1,3,4,*, Yongning Zhou^1,3,4,*

BIOCELL, Vol.49, No.10, pp. 1967-1983, 2025, DOI:10.32604/biocell.2025.069869 - 22 October 2025

Abstract Background: Gastric cancer (GC) is a prevalent cause of death. 3,9-Di-O-methylnissolin (DOM) is a flavonoid isolated from Astragalus membranaceus. It has anticancer and anti-inflammatory effects, but its effect and mechanism of action on GC are not very clear. Methods: The appropriate concentration was selected after observing the effects of varying concentrations of DOM on the viability of GC cells, which was examined through the cell counting kit-8 (CCK-8) assay. The receptor-interacting protein kinase 2 (RIPK2) overexpression plasmid was transfected into GC cells, which were then treated with DOM. Cell cycle and proliferation, RIPK2 levels, and inflammatory… More > Graphic Abstract

Junxing Chen^1,#, Luping Pan^1,#, Yunzhi Liu^1,2, Yan Fang¹, Ruoxuan Li¹, Zhiqin Lu^1,3, Anwen Liu^1,4, Yanqing He^5,*, Zhimin Zeng^1,6,*

Oncology Research, Vol.33, No.8, pp. 2107-2121, 2025, DOI:10.32604/or.2025.064237 - 18 July 2025

Abstract Background: Non-small cell lung cancer (NSCLC) patients with leptomeningeal metastasis (LM) have a very poor prognosis. Intrathecal pemetrexed (IP) has shown moderate efficacy in treating patients with NSCLC-LM. Myelosuppression is the most common adverse effect following IP administration. Despite this trend, the specific risk factors contributing to IP-related myelosuppression remain unclear. Methods: This study conducted a retrospective analysis of lung adenocarcinoma (LUAD) patients with LM who received IP treatment at the Second Affiliated Hospital of Nanchang University from April 2017 to April 2024. Risk factors for myelosuppression were identified through univariate and multivariate logistic regression… More >

Tianshuo Liu^1,2, Xiaoyu Cui¹, Lihao Lu^2,3, Kongkuai Ying^2,*, Yang Wang^2,3, Kangjun Liu², Zilong Wang¹, Zhenhua Jiang^2,3, Shaoshuai Liu^2,3,*

Frontiers in Heat and Mass Transfer, Vol.23, No.3, pp. 739-750, 2025, DOI:10.32604/fhmt.2025.064532 - 30 June 2025

Abstract Helium sorption cooler technology is a key means to realize highly reliable low-vibration very low-temperature environments, which have important applications in fields such as quantum computing and space exploration. The laboratory designed a superfluid suppression small hole and a multi-ribbed condenser, developed a reliable-performance helium sorption cooler (HSC), and conducted experimental studies. Experimental results show that the prototype can achieve the lowest cooling temperature of 873 mK without load by filling 6 MPa helium at room temperature. The low-temperature hold time is 26 h, and the temperature fluctuation is within 0.8 mK. The cooling power More >

Lihua Zuo^1,2,#, Jian Mao^2,#,*

Journal of Psychology in Africa, Vol.35, No.2, pp. 241-247, 2025, DOI:10.32604/jpa.2025.065765 - 30 June 2025

Abstract This study examined how social desirability responses confound the relationship between gender and social media addiction. A total of 496 college student social media users (females = 310, 62.5%, mean age = 20.15, SD = 1.26) completed an online questionnaire on Social Media Addiction and Social Desirability. Mediation analysis revealed that females were at higher risk for social media addiction. On the other hand, the indirect effect of gender on social media addiction via social desirability is associated with lower social media addiction, which suggests that social desirability had a suppression effect on social media More >

Qiang Guo^1,2,*, Rubo Zhang¹, Bingbing Zhang³

CMC-Computers, Materials & Continua, Vol.84, No.1, pp. 1307-1327, 2025, DOI:10.32604/cmc.2025.063288 - 09 June 2025

Abstract Pedestrian detection has been a hot spot in computer vision over the past decades due to the wide spectrum of promising applications, and the major challenge is false positives that occur during pedestrian detection. The emergence of various Convolutional Neural Network-based detection strategies substantially enhances pedestrian detection accuracy but still does not solve this problem well. This paper deeply analyzes the detection framework of the two-stage CNN detection methods and finds out false positives in detection results are due to its training strategy misclassifying some false proposals, thus weakening the classification capability of the following… More >

MIAO YAN¹, DONGXUAN CHI², WEN WANG³, PEI PEI⁴, MIN XIE¹, SHUANGLING LI^1,*

BIOCELL, Vol.49, No.5, pp. 893-906, 2025, DOI:10.32604/biocell.2025.063622 - 27 May 2025

Abstract Background: Transcription factor Krüppel-like factor 3 (KLF3) may be involved in regulating inflammation and lymphocyte function. Immune dysfunction in sepsis involves both hyper-inflammation and immunosuppression. However, studies on T-lymphocyte KLF3 expression in sepsis are lacking. Methods: We induced sepsis in mice via cecal ligation and puncture (CLP), and their survival rate over 7 days was evaluated. To identify the immune status of these mice, we assessed their cytokine levels, organ damage scores, and splenic T-lymphocyte phenotype. Finally, T-lymphocyte KLF3 expression was detected through flow cytometry. Results: Over the 7 days of observation, septic mice demonstrated 64.7%… More >

Youming Song^*, Yuxin Li, Yin Wang, Yuan Xie, Gang Qiao, Jingyi Chen

Journal of Psychology in Africa, Vol.35, No.1, pp. 51-59, 2025, DOI:10.32604/jpa.2025.065781 - 30 April 2025

Abstract Although numerous findings show that people experience both positive and negative experiences with regards to solitude, the relationship between solitude capacity and emotional experience remains unclear. The current study investigated the extent to which emotion regulation may play a suppressive role in the relationship between solitude capacity and emotional experience. Questionnaires on solitude capacity, emotion regulation, and emotional experience were completed by a sample of Chinese college students (n = 844; 432 females; Mean_age = 19.79 years, SD = 1.43 years). The results of the indirect effect test showed that cognitive reappraisal suppresses the prediction of solitude More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.4, pp. 989-989, 2025, DOI:10.32604/or.2024.056912 - 19 March 2025

Abstract This article has no abstract. More >

Qian Yang, Alina Leonie Ruff, Lydia Meder^*

BIOCELL, Vol.49, No.2, pp. 161-165, 2025, DOI:10.32604/biocell.2025.060227 - 28 February 2025

Abstract This article has no abstract. More >

Meng Zhao¹, Jiaao Liu², Yudi Liu³, Zhengwei Long^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1545-1564, 2025, DOI:10.32604/cmes.2025.058773 - 27 January 2025

Abstract Computational Fluids Dynamics (CFD) simulations are essential for optimizing the design of a cockpit’s internal environment, but the complex geometric models consume a significant amount of computational resources and time. Arbitrary simplification of geometric models may result in inaccurate calculations of physical fields. To address this issue, this study establishes a geometric model simplification strategy and successfully applies it to a cockpit. The implementation of the whole approach is divided into three steps, summarized in three methods, namely Sensitivity Analysis Method (SAM), Detail Suppression Method (DSM), and Evaluation Standards Method (ESM). Sensitivity analysis of the More >