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  • Open Access

    ARTICLE

    Salubrinal alleviates traumatic spinal cord injury through suppression of the eIF2α/ATF4 pathway in mouse model

    XINFU FAN1,2,#, JIE CHEN3,#, ZONGMENG ZHANG4,#, FANGHUI CHEN5, HAOSEN WANG6, YAFEI CAI6, JUN LI7,*

    BIOCELL, Vol.46, No.6, pp. 1527-1535, 2022, DOI:10.32604/biocell.2022.018269

    Abstract Spinal cord injury (SCI) remains an intractable clinical challenge of neurosurgery, it can be divided into two stages: uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death. The apoptosis was the one of most important events in secondary injury, previous studies revealed that excessive endoplasmic reticulum (ER) stress breaks down the homeostasis and triggers apoptosis in the spinal cord. To deter or alleviate the secondary jury, we screen one of fat-soluble compounds, salubrinal, which was an inhibitor of eIF2α dephosphorylation can repair SCI by inhibiting ER stress in mice after SCI. Administration of… More >

  • Open Access

    ARTICLE

    Bio-Based Trivalent Phytate: A Novel Strategy for Enhancing Fire Performance of Rigid Polyurethane Foam Composites

    Bing Zhang1, Sujie Yang1, Mengru Liu1, Panyue Wen2, Xiuyu Liu1, Gang Tang1,*, Xiangrong Xu3,4,*

    Journal of Renewable Materials, Vol.10, No.5, pp. 1201-1220, 2022, DOI:10.32604/jrm.2022.018047

    Abstract Biomass phytic acid has potential flame retardant value as the main form of phosphorus in plant seeds. In this study, phytate-based flame retardants aluminum phytate (PA-Al) and iron phytate (PA-Fe) were synthesized and characterized. Subsequently, they were introduced into rigid polyurethane foam (RPUF) as flame retardants by one-step water-blown method. The results indicated that RPUF/PA-Fe30 exhibited the highest char residue of 22.1 wt%, significantly higher than 12.4 wt% of RPUF. Cone calorimetry analysis showed that the total heat release (THR) of RPUF/PA-Al30 decreased by 17.0% and total smoke release (TSR) decreased by 22.0% compared with pure RPUF, which were the lowest, demonstrating… More > Graphic Abstract

    Bio-Based Trivalent Phytate: A Novel Strategy for Enhancing Fire Performance of Rigid Polyurethane Foam Composites

  • Open Access

    REVIEW

    Alteration in the expression of microRNA-21 regulated target genes: Role in breast cancer

    PRIYANKA THAKUR1, REENA V. SAINI2,3,*, ANIL K. CHHILLAR4, NEERAJ K. SAINI5, VIJAY KUMAR THAKUR6, SAMARJEET SINGH SIWAL7, ADESH K. SAINI2,3,*

    BIOCELL, Vol.46, No.2, pp. 309-324, 2022, DOI:10.32604/biocell.2022.016916

    Abstract Breast cancer, also recognized as the principal cause of cancer-related deaths among women, is the second most familiar and prevalent form of cancer. New diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early prognosis. MicroRNAs (miRNAs), a class of non-coding RNAs, are known to control the biological processes involving transcription, post-transcriptional and covalent modifications, splicing, translation, cell differentiation, proliferation, apoptosis, cancer progression, and invasion. Any dysregulation in miRNA expression, demonstrating their oncogenic and tumor-suppressive functions, contributes to cancer progression. MicroRNA-21 (miR-21), an ‘onco-miR’ in breast cancer, is involved in tumor progression and metastasis by suppressing… More >

  • Open Access

    ARTICLE

    A Novel Starting Impulse Suppression Method for Active Power Filter Based on Slowly Rising Curve

    Jianfeng Yang*, Yu Ding

    Energy Engineering, Vol.118, No.6, pp. 1839-1853, 2021, DOI:10.32604/EE.2021.015930

    Abstract With the widespread application of power electronic equipment in the power grid, the harmonic problem of the power grid becomes more pronounced, reducing the efficiency of power production, transmission, and utilization, and interfering with the normal operation of the power grid. Based on the requirements of harmonic suppression and power system protection, a shunt active power filter (SAPF) is proposed as an effective harmonic suppression method. However, there are problems with impulse current and impulse voltage in the starting process of SAPF. Impulse current and impulse voltage cause the power grid and switchgear to bear greater current stress and voltage… More >

  • Open Access

    ARTICLE

    Suppression Effects on Pineapple Soil-Borne Pathogens by Crotalaria juncea, Dolomitic Lime and Plastic Mulch Cover on MD-2 Hybrid Cultivar

    Luis Alfonso Aguilar Pérez1,*, Daniel Nieto Ángel1,*, Moisés Roberto Vallejo Pérez2, Daniel Leobardo Ochoa Martínez1, David Espinosa Victoria3, Andrés Rebolledo Martinez4, Abel Rebouças São José5

    Phyton-International Journal of Experimental Botany, Vol.90, No.4, pp. 1205-1216, 2021, DOI:10.32604/phyton.2021.015109

    Abstract The development and implementation of sustainable and environmentally friendly agricultural practices are indispensable as alternatives to pesticide use and to keep populations of soil-borne plant pathogens at levels that do not affect crop productivity. The present research evaluates the incidence of soil-borne phytopathogens on the pineapple variety MD-2, which was subjected to different treatments: Incorporation of Crotalaria juncea into the soil (organic amendment), application of dolomitic lime to soil (inorganic amendment), and the use of plastic mulch covering the soil. During the crop cycle (15 months), the following variables were evaluated: plant height (cm), fruit weight (kg·plant−1 ), crop yield… More >

  • Open Access

    ARTICLE

    Plasma HGF and OPN as Potential Biomarkers of Pulmonary Arterial Hypertension in Congenital Heart Disease

    Dongdong Zheng1,#, Chi Shen1,2,#, Wenshi Liu1, Wenjing Lv1, Xiaofei Li1,*

    Congenital Heart Disease, Vol.16, No.4, pp. 373-381, 2021, DOI:10.32604/CHD.2021.015260

    Abstract Objectives: Pulmonary arterial hypertension in congenital heart disease (PAH-CHD) is the most common type of PAH and increases morbidity and mortality in patients with CHD. Right heart catheterization (RHC) is the standard method to diagnose PAH. However, RHC is an invasive and complicated method with relatively high cost. Noninvasive, feasible, and cost-efficient methods are urgently needed. The objective of this study was to evaluate three potential biomarkers of PAH-CHD: Hepatocyte growth factor (HGF), osteopontin (OPN), and suppression of tumorigenicity 2 (ST2). Methods: Plasma samples were collected from patients with CHD (n = 46) and healthy individuals (n = 22) and… More >

  • Open Access

    ARTICLE

    A Subsynchronous Oscillation Suppression Method Based on Self-Adaptive Auto Disturbance Rejection Proportional Integral Control of Voltage Source Converter Based Multi-Terminal Direct Current System with Doubly-Fed Induction Generator-Based Wind Farm Access

    Miaohong Su1, Haiying Dong1,2,*, Kaiqi Liu1, Weiwei Zou1

    Energy Engineering, Vol.117, No.6, pp. 439-452, 2020, DOI:10.32604/EE.2020.011805

    Abstract A subsynchronous oscillation suppression strategy based on self-adaptive auto disturbance rejection proportional integral controller is proposed for doublyfed induction generator-based wind farm integrated into grid through voltage source converter based multi-terminal direct current. In this strategy, the nonlinear PI controller is constructed by fal function to replace the traditional linear PI controller, and then the tracking differentiator is used to arrange the appropriate transition process in combination with the idea of active disturbance rejection control, and the self-adaptive auto disturbance rejection proportional integral controller is designed. By applying the controller to the inner loop of the converter on the rotor… More >

  • Open Access

    ARTICLE

    Position and Velocity Time Delay for Suppression Vibrations of a Hybrid Rayleigh-Van der Pol-Duffing Oscillator

    Y. A. Amer1, A. T. El-Sayed2, M. N. Abd El-Salam3,*

    Sound & Vibration, Vol.54, No.3, pp. 149-161, 2020, DOI:10.32604/sv.2020.08469

    Abstract In this paper, we used time delay feedback to minimize the vibrations of a hybrid Rayleigh–van der Pol–Duffing oscillator. This system is a one-degree-offreedom containing the cubic and fifth nonlinear terms and an external force. We applied the multiple scales method to get the solution from first approximation. Graphically and numerically, we studied the system before and after adding time delay feedback at the primary resonance case (Ω ≌ ω). We used MATLAB program to simulate the efficacy of different parameters and the time delay on the main system. More >

  • Open Access

    ARTICLE

    Preparation and Characterization of Tung Oil Toughened Modified Phenolic Foams with Enhanced Mechanical Properties and Smoke Suppression

    Fei Song1,2, Puyou Jia1,*, Caiying Bo1, Xiaoli Ren1, Lihong Hu1, Yonghong Zhou1,*

    Journal of Renewable Materials, Vol.8, No.5, pp. 535-547, 2020, DOI:10.32604/jrm.2020.09304

    Abstract In this study, we prepared a series of tung oil phenolic foams (TPF) by a one-pot method. The FT-IR and 1 H NMR spectra confirm the successful FriedelCrafts grafting of phenol to the long-chain alkyl group in tung oil. Modified TPFs exhibit enhanced mechanical properties, including compressive and flexural strengths of up to 0.278 ± 0.036 MPa and 0.450 ± 0.017 MPa, respectively, which represent increases of 68.75% and 86.72% over those of pure phenolic foam (PF). SEM spectra reveal the TPF microstructure to have uniform hexagonal cell morphology, narrower cell size distribution, and smaller mean cell size, suggesting enhanced… More >

  • Open Access

    ABSTRACT

    Positive Position Feedback Control for Active Suppression of Impact-induced Vibrations Using a Point-wise Fiber Bragg Grating Displacement Sensing System

    K.C. Chuang, C.C. Ma, C.H. Wang

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.19, No.1, pp. 1-2, 2011, DOI:10.3970/icces.2011.019.001

    Abstract Smart flexible structures involve four key elements: actuators, sensors, control strategies, and power conditioning electronics, which makes the structures being capable of realizing specific functions. Recently, fiber Bragg grating (FBG) strain sensors are being considered to be integrated into smart structures since they possess many excellent properties such as low density, small size, simplicity of fabrication, and immunity to electromagnetic fields. In this paper, unlike traditional FBG strain sensors, a fiber Bragg grating (FBG) sensing system which has the ability to detect point-wise out-of-plane displacement responses is set up on a smart cantilever beam to perform active vibration control. The… More >

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