NIMA HEMMAT¹, MOHAMMAD AMIN DOUSTVANDI¹, ZAHRA ASADZADEH¹, AHAD MOKHTARZADEH¹, BEHZAD BARADARAN^1,4,*, HOSSEIN BANNAZADEH BAGHI^1,2,3,*

Oncology Research, Vol.29, No.2, pp. 141-148, 2021, DOI:10.32604/or.2022.023346

Abstract Cervical cancer is a growing global disease in developing countries. Persistent infection with human papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5 oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle, apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer cells. The results demonstrate that… More >

Jie Xu^*1, Zhongzhou Su^*1, Qiuping Ding^†, Liang Shen^*, Xiaohu Nie^*, Xuyan Pan^*, Ai Yan^*, Renfu Yan^*, Yue Zhou^*, Liqin Li^‡, Bin Lu^*

Oncology Research, Vol.27, No.7, pp. 819-826, 2019, DOI:10.3727/096504018X15478559215014

Abstract Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remain poorly understood. Herein we found that mRNA levels of TMEM168 were overexpressed in GBM patients (n=85) when compared with healthy people (n=10), which was also supported by data from The Cancer Genome Atlas (TCGA). Kaplan–Meier analysis of Gene Expression Omnibus dataset GSE16011 suggested that enhanced TMEM168 expression was associated with shorter survival time. To investigate whether and how TMEM168 functioned in… More >

Majed Al Fayi^*†, Ahmad Alamri^*, Prasanna Rajagopalan^*†

Oncology Research, Vol.28, No.2, pp. 177-189, 2020, DOI:10.3727/096504019X15746768080428

Abstract Drug discovery research to fight lung cancer is incessantly challenged by drug resistance. In this study, we used drug-resistant lung cancer stem like cells (A549-CS) to compare the efficacy of standard drugs like cisplatin (DDP) and gemcitabine (GEM) with a novel arylidene derivative IOX-101. A549-CS was derived from regular A549 cells by growing in special media. Resistance proteins were detected using Western blotting. Cell proliferations were assessed by MTT assay. Cytokine release was enumerated using enzyme-linked immunosorbent assay. The effect of drugs on apoptosis and cell cycle was studied with flow cytometry protocols. Apoptosis-related proteins, caspases, and other signaling protein… More >

Qie Guo^*, Xiao Li^*, Meng-Na Cui^*, Jia-Lin Sun^*, Hong-Yan Ji^*, Bei-Bei Ni^*, Mei-Xing Yan^†

Oncology Research, Vol.28, No.5, pp. 533-540, 2020, DOI:10.3727/096504020X15919605976853

Abstract Cancer is one of the most serious diseases that are harmful to human health. Systemic chemotherapy is an optimal therapeutic strategy for the treatment of cancer, but great difficulty has been encountered in its administration in the form of multidrug resistance (MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved in the MDR development of tumor cells. In this review, we will focus on the role of CD13 in MDR generation based on the current evidence. More >

Meixian Li¹, Xin Hu¹, Jie Yang¹, Hongyu Yang^1,3,*, Yao Yuan^2,*

Journal of Renewable Materials, Vol.10, No.10, pp. 2639-2654, 2022, DOI:10.32604/jrm.2022.019491

Abstract In this work, a bio-based flame retardant (Cy-HEDP) was synthesized from cytosine and HEDP through a facile salt-forming reaction and embedded into epoxy matrix to improve the flame retardancy and smoke suppression performance. The product Cy-HEDP was well characterized by FTIR, ¹ H and ³¹P NMR and SEM tests. On the basis of the results, by adding 15 wt% Cy-HEDP, the EP₁₅ can pass UL-94 V-0 rating, and the total smoke production (TSP) as well as total heat release (THR) can be decreased by 61.05% (from 22.61 to 8.7 m² /m² ) and 39.44% (from 103.19 to 62.50 MJ/m² )… More > Graphic Abstract

Pengfei Guan¹, Ping Li², Yiqiang Wu¹, Xingong Li¹, Guangming Yuan¹, Yingfeng Zuo^1,*

Journal of Renewable Materials, Vol.10, No.9, pp. 2451-2463, 2022, DOI:10.32604/jrm.2022.020459

Abstract To enhance mechanical properties and improve flame retardancy and smoke suppression of fast-growing poplar wood in wood applications, the wood was impregnated and modified. An organic phenolic prepolymer and inorganic sodium silicate was used as contrasting impregnation modifiers and wood samples were impregnated by a bionic “respiration” method with alternating positive and negative pressure. The weight percentage gain, density increase ratio, mechanical properties (bending and compressive strength and hardness), and water absorption rate of inorganic and organic-impregnated modified poplar wood (IIMPW and OIMPW, respectively) were compared and these properties in IIMPW were found to be higher than those of OIMPW… More >

MASASHI KAWAMI^*, RYOKO YUMOTO, MIKIHISA TAKANO

BIOCELL, Vol.46, No.8, pp. 1861-1865, 2022, DOI:10.32604/biocell.2022.019667

Abstract A number of drugs induce pulmonary injury and subsequently lead to serious lung diseases such as pulmonary fibrosis as the adverse drug reactions. However, an effective preventive approach against drug-induced pulmonary fibrosis has not been established due to poor understanding of common preventive targets in a variety of drugs showing pulmonary toxicity. Epithelial-mesenchymal transition (EMT), a cellular phenotypic change of the epithelial to mesenchymal state, contributes to the development of pulmonary fibrosis through the conversion of damaged alveolar epithelium into myofibroblasts. As several drugs with pulmonary toxicity have been reported to induce EMT, EMT serves as a bridge between the… More >

Y. A. Amer¹, A. T. EL-Sayed², M. N. Abd EL-Salam^3,*

Sound & Vibration, Vol.56, No.2, pp. 89-104, 2022, DOI:10.32604/sv.2022.011838

Abstract In our consideration, a comparison between four different types of controllers for suppression the vibrations of the cantilever beam excited by an external force is carried out. Those four types are the linear velocity feedback control, the cubic velocity feedback control, the non-linear saturation controller (NSC) and the positive position feedback (PPF) controller. The suitable type is the PPF controller for suppression the vibrations of the cantilever beam. The approximate solution obtained up to the first approximation by using the multiple scale method. The PPF controller effectiveness is studied on the system. We used frequency-response equations to investigate the stability… More >

Álvaro Rodríguez-Peña¹, Ana C. Gonzalez-Franco¹, Jared Hernández-Huerta¹, Nora A. Salas-Salazar¹, Dámaris L. Ojeda-Barrios¹, Esteban Sánchez², Loreto Robles-Hernández^1,*

Phyton-International Journal of Experimental Botany, Vol.91, No.7, pp. 1341-1351, 2022, DOI:10.32604/phyton.2022.019728

Abstract Antibiotics are widely used in fire blight management programs, yet there are no studies that demonstrate the evaluation of their efficacy in Mexico. Therefore, the present study was conducted to investigate the effects of the active ingredients in five commercial products (Kasumin^® 2L, Agrygent Plus^®, Agricultural Terramycin^®, Agrimicin^® 100, and Actigard^®) on fire blight suppression, and fruit yield and quality of apple (Malus domestica Borkh.) cv. Golden Glory. The experiment was conducted in a commercial orchard using a completely randomized block design, with six treatments: (1) Oxytetracycline [Ox], 110 mg L⁻¹; (2) Kasugamycin [Kas], 4.7 mL L⁻¹; (3) Oxytetracycline + Gentamicin [Ox… More >

Peipei Hong^1,#, Mei Wang^2,#, Liting Zhi², Hongwei Chen^2,3,4,*, Kefeng Liu¹, Hongli Wang²

Phyton-International Journal of Experimental Botany, Vol.91, No.6, pp. 1211-1226, 2022, DOI:10.32604/phyton.2022.018435

Abstract The branching system of higher plants plays a very important role in plant morphogenesis, and the number of branches can directly affect crop yield and the ornamental value of plants. It is a complicated development process involving complex molecular mechanisms. The ‘Cailinghong’ variety of Salvia splendens is characterized by its great branching ability with the ability to grow into a spherical form naturally, without pinching. To gain insight into the molecular events during the branching development of S. splendens, suppressive subtractive hybridization (SSH) technology was used to screen differentially expressed genes between the erect plant type (strain 35) and the… More >