XINFU FAN^1,2,#, JIE CHEN^3,#, ZONGMENG ZHANG^4,#, FANGHUI CHEN⁵, HAOSEN WANG⁶, YAFEI CAI⁶, JUN LI^7,*

BIOCELL, Vol.46, No.6, pp. 1527-1535, 2022, DOI:10.32604/biocell.2022.018269 - 07 February 2022

Abstract Spinal cord injury (SCI) remains an intractable clinical challenge of neurosurgery, it can be divided into two stages: uncontrollable primary injury induced by mechanical damage and controllable secondary injury regulated by continuous cell death. The apoptosis was the one of most important events in secondary injury, previous studies revealed that excessive endoplasmic reticulum (ER) stress breaks down the homeostasis and triggers apoptosis in the spinal cord. To deter or alleviate the secondary jury, we screen one of fat-soluble compounds, salubrinal, which was an inhibitor of eIF2α dephosphorylation can repair SCI by inhibiting ER stress in… More >

Bing Zhang¹, Sujie Yang¹, Mengru Liu¹, Panyue Wen², Xiuyu Liu¹, Gang Tang^1,*, Xiangrong Xu^3,4,*

Journal of Renewable Materials, Vol.10, No.5, pp. 1201-1220, 2022, DOI:10.32604/jrm.2022.018047 - 22 December 2021

Abstract Biomass phytic acid has potential flame retardant value as the main form of phosphorus in plant seeds. In this study, phytate-based flame retardants aluminum phytate (PA-Al) and iron phytate (PA-Fe) were synthesized and characterized. Subsequently, they were introduced into rigid polyurethane foam (RPUF) as flame retardants by one-step water-blown method. The results indicated that RPUF/PA-Fe30 exhibited the highest char residue of 22.1 wt%, significantly higher than 12.4 wt% of RPUF. Cone calorimetry analysis showed that the total heat release (THR) of RPUF/PA-Al30 decreased by 17.0% and total smoke release (TSR) decreased by 22.0% compared with pure RPUF, More > Graphic Abstract

PRIYANKA THAKUR¹, REENA V. SAINI^2,3,*, ANIL K. CHHILLAR⁴, NEERAJ K. SAINI⁵, VIJAY KUMAR THAKUR⁶, SAMARJEET SINGH SIWAL⁷, ADESH K. SAINI^2,3,*

BIOCELL, Vol.46, No.2, pp. 309-324, 2022, DOI:10.32604/biocell.2022.016916 - 20 October 2021

Abstract Breast cancer, also recognized as the principal cause of cancer-related deaths among women, is the second most familiar and prevalent form of cancer. New diagnostic and prognostic biomarkers that are highly specific are urgently needed for its early prognosis. MicroRNAs (miRNAs), a class of non-coding RNAs, are known to control the biological processes involving transcription, post-transcriptional and covalent modifications, splicing, translation, cell differentiation, proliferation, apoptosis, cancer progression, and invasion. Any dysregulation in miRNA expression, demonstrating their oncogenic and tumor-suppressive functions, contributes to cancer progression. MicroRNA-21 (miR-21), an ‘onco-miR’ in breast cancer, is involved in tumor… More >

Matt Ghiji^a,*, Ian Burch^b, Brigitta Suendermann^b, Grant Gamble^b, Vasily Novozhilov ^a, Paul Joseph^a, Khalid Moinuddin^a

Frontiers in Heat and Mass Transfer, Vol.17, pp. 1-8, 2021, DOI:10.5098/hmt.17.13

Abstract Lithium-ion batteries (LiBs) have superior energy density and lifetime compared to battery technologies such as lead acid. Despite the widespread application of LiBs in energy storage systems, electronic devices, aerospace and the automotive industry, they present a fire risk. In this study, experiments were conducted to characterize the thermal behavior of the electrolyte (as the main contributor to LiB fires) using a cone calorimeter; investigate the interactions of water mist and a Bunsen burner, as a precursor to examining the effectiveness of a water mist suppression system in extinguishing a LiB fire. In the present… More >

NIMA HEMMAT¹, MOHAMMAD AMIN DOUSTVANDI¹, ZAHRA ASADZADEH¹, AHAD MOKHTARZADEH¹, BEHZAD BARADARAN^1,4,*, HOSSEIN BANNAZADEH BAGHI^1,2,3,*

Oncology Research, Vol.29, No.2, pp. 141-148, 2021, DOI:10.32604/or.2022.023346 - 13 July 2022

Abstract Cervical cancer is a growing global disease in developing countries. Persistent infection with human papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5 oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle, apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer More >

Jianfeng Yang^*, Yu Ding

Energy Engineering, Vol.118, No.6, pp. 1839-1853, 2021, DOI:10.32604/EE.2021.015930 - 10 September 2021

Abstract With the widespread application of power electronic equipment in the power grid, the harmonic problem of the power grid becomes more pronounced, reducing the efficiency of power production, transmission, and utilization, and interfering with the normal operation of the power grid. Based on the requirements of harmonic suppression and power system protection, a shunt active power filter (SAPF) is proposed as an effective harmonic suppression method. However, there are problems with impulse current and impulse voltage in the starting process of SAPF. Impulse current and impulse voltage cause the power grid and switchgear to bear… More >

Luis Alfonso Aguilar Pérez^1,*, Daniel Nieto Ángel^1,*, Moisés Roberto Vallejo Pérez², Daniel Leobardo Ochoa Martínez¹, David Espinosa Victoria³, Andrés Rebolledo Martinez⁴, Abel Rebouças São José⁵

Phyton-International Journal of Experimental Botany, Vol.90, No.4, pp. 1205-1216, 2021, DOI:10.32604/phyton.2021.015109 - 27 April 2021

Abstract The development and implementation of sustainable and environmentally friendly agricultural practices are indispensable as alternatives to pesticide use and to keep populations of soil-borne plant pathogens at levels that do not affect crop productivity. The present research evaluates the incidence of soil-borne phytopathogens on the pineapple variety MD-2, which was subjected to different treatments: Incorporation of Crotalaria juncea into the soil (organic amendment), application of dolomitic lime to soil (inorganic amendment), and the use of plastic mulch covering the soil. During the crop cycle (15 months), the following variables were evaluated: plant height (cm), fruit weight (kg·plant⁻¹… More >

Dongdong Zheng^1,#, Chi Shen^1,2,#, Wenshi Liu¹, Wenjing Lv¹, Xiaofei Li^1,*

Congenital Heart Disease, Vol.16, No.4, pp. 373-381, 2021, DOI:10.32604/CHD.2021.015260 - 19 April 2021

Abstract Objectives: Pulmonary arterial hypertension in congenital heart disease (PAH-CHD) is the most common type of PAH and increases morbidity and mortality in patients with CHD. Right heart catheterization (RHC) is the standard method to diagnose PAH. However, RHC is an invasive and complicated method with relatively high cost. Noninvasive, feasible, and cost-efficient methods are urgently needed. The objective of this study was to evaluate three potential biomarkers of PAH-CHD: Hepatocyte growth factor (HGF), osteopontin (OPN), and suppression of tumorigenicity 2 (ST2). Methods: Plasma samples were collected from patients with CHD (n = 46) and healthy individuals (n… More >

Majed Al Fayi^*†, Ahmad Alamri^*, Prasanna Rajagopalan^*†

Oncology Research, Vol.28, No.2, pp. 177-189, 2020, DOI:10.3727/096504019X15746768080428

Abstract Drug discovery research to fight lung cancer is incessantly challenged by drug resistance. In this study, we used drug-resistant lung cancer stem like cells (A549-CS) to compare the efficacy of standard drugs like cisplatin (DDP) and gemcitabine (GEM) with a novel arylidene derivative IOX-101. A549-CS was derived from regular A549 cells by growing in special media. Resistance proteins were detected using Western blotting. Cell proliferations were assessed by MTT assay. Cytokine release was enumerated using enzyme-linked immunosorbent assay. The effect of drugs on apoptosis and cell cycle was studied with flow cytometry protocols. Apoptosis-related proteins,… More >

Qie Guo^*, Xiao Li^*, Meng-Na Cui^*, Jia-Lin Sun^*, Hong-Yan Ji^*, Bei-Bei Ni^*, Mei-Xing Yan^†

Oncology Research, Vol.28, No.5, pp. 533-540, 2020, DOI:10.3727/096504020X15919605976853

Abstract Cancer is one of the most serious diseases that are harmful to human health. Systemic chemotherapy is an optimal therapeutic strategy for the treatment of cancer, but great difficulty has been encountered in its administration in the form of multidrug resistance (MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved in the MDR development of tumor cells. In this review, we will focus on the role of CD13 in MDR generation based on the current evidence. More >