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  • Open Access

    ARTICLE

    Suppression Effects on Pineapple Soil-Borne Pathogens by Crotalaria juncea, Dolomitic Lime and Plastic Mulch Cover on MD-2 Hybrid Cultivar

    Luis Alfonso Aguilar Pérez1,*, Daniel Nieto Ángel1,*, Moisés Roberto Vallejo Pérez2, Daniel Leobardo Ochoa Martínez1, David Espinosa Victoria3, Andrés Rebolledo Martinez4, Abel Rebouças São José5

    Phyton-International Journal of Experimental Botany, Vol.90, No.4, pp. 1205-1216, 2021, DOI:10.32604/phyton.2021.015109 - 27 April 2021

    Abstract The development and implementation of sustainable and environmentally friendly agricultural practices are indispensable as alternatives to pesticide use and to keep populations of soil-borne plant pathogens at levels that do not affect crop productivity. The present research evaluates the incidence of soil-borne phytopathogens on the pineapple variety MD-2, which was subjected to different treatments: Incorporation of Crotalaria juncea into the soil (organic amendment), application of dolomitic lime to soil (inorganic amendment), and the use of plastic mulch covering the soil. During the crop cycle (15 months), the following variables were evaluated: plant height (cm), fruit weight (kg·plant−1More >

  • Open Access

    ARTICLE

    Plasma HGF and OPN as Potential Biomarkers of Pulmonary Arterial Hypertension in Congenital Heart Disease

    Dongdong Zheng1,#, Chi Shen1,2,#, Wenshi Liu1, Wenjing Lv1, Xiaofei Li1,*

    Congenital Heart Disease, Vol.16, No.4, pp. 373-381, 2021, DOI:10.32604/CHD.2021.015260 - 19 April 2021

    Abstract Objectives: Pulmonary arterial hypertension in congenital heart disease (PAH-CHD) is the most common type of PAH and increases morbidity and mortality in patients with CHD. Right heart catheterization (RHC) is the standard method to diagnose PAH. However, RHC is an invasive and complicated method with relatively high cost. Noninvasive, feasible, and cost-efficient methods are urgently needed. The objective of this study was to evaluate three potential biomarkers of PAH-CHD: Hepatocyte growth factor (HGF), osteopontin (OPN), and suppression of tumorigenicity 2 (ST2). Methods: Plasma samples were collected from patients with CHD (n = 46) and healthy individuals (nMore >

  • Open Access

    ARTICLE

    IOX-101 Reverses Drug Resistance Through Suppression of Akt/mTOR/NF-κB Signaling in Cancer Stem Cell-Like, Sphere-Forming NSCLC Cell

    Majed Al Fayi*†, Ahmad Alamri*, Prasanna Rajagopalan*†

    Oncology Research, Vol.28, No.2, pp. 177-189, 2020, DOI:10.3727/096504019X15746768080428

    Abstract Drug discovery research to fight lung cancer is incessantly challenged by drug resistance. In this study, we used drug-resistant lung cancer stem like cells (A549-CS) to compare the efficacy of standard drugs like cisplatin (DDP) and gemcitabine (GEM) with a novel arylidene derivative IOX-101. A549-CS was derived from regular A549 cells by growing in special media. Resistance proteins were detected using Western blotting. Cell proliferations were assessed by MTT assay. Cytokine release was enumerated using enzyme-linked immunosorbent assay. The effect of drugs on apoptosis and cell cycle was studied with flow cytometry protocols. Apoptosis-related proteins,… More >

  • Open Access

    REVIEW

    CD13: A Key Player in Multidrug Resistance in Cancer Chemotherapy

    Qie Guo*, Xiao Li*, Meng-Na Cui*, Jia-Lin Sun*, Hong-Yan Ji*, Bei-Bei Ni*, Mei-Xing Yan

    Oncology Research, Vol.28, No.5, pp. 533-540, 2020, DOI:10.3727/096504020X15919605976853

    Abstract Cancer is one of the most serious diseases that are harmful to human health. Systemic chemotherapy is an optimal therapeutic strategy for the treatment of cancer, but great difficulty has been encountered in its administration in the form of multidrug resistance (MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved in the MDR development of tumor cells. In this review, we will focus on the role of CD13 in MDR generation based on the current evidence. More >

  • Open Access

    ARTICLE

    A Subsynchronous Oscillation Suppression Method Based on Self-Adaptive Auto Disturbance Rejection Proportional Integral Control of Voltage Source Converter Based Multi-Terminal Direct Current System with Doubly-Fed Induction Generator-Based Wind Farm Access

    Miaohong Su1, Haiying Dong1,2,*, Kaiqi Liu1, Weiwei Zou1

    Energy Engineering, Vol.117, No.6, pp. 439-452, 2020, DOI:10.32604/EE.2020.011805 - 16 October 2020

    Abstract A subsynchronous oscillation suppression strategy based on self-adaptive auto disturbance rejection proportional integral controller is proposed for doublyfed induction generator-based wind farm integrated into grid through voltage source converter based multi-terminal direct current. In this strategy, the nonlinear PI controller is constructed by fal function to replace the traditional linear PI controller, and then the tracking differentiator is used to arrange the appropriate transition process in combination with the idea of active disturbance rejection control, and the self-adaptive auto disturbance rejection proportional integral controller is designed. By applying the controller to the inner loop of the… More >

  • Open Access

    ARTICLE

    Position and Velocity Time Delay for Suppression Vibrations of a Hybrid Rayleigh-Van der Pol-Duffing Oscillator

    Y. A. Amer1, A. T. El-Sayed2, M. N. Abd El-Salam3,*

    Sound & Vibration, Vol.54, No.3, pp. 149-161, 2020, DOI:10.32604/sv.2020.08469 - 31 August 2020

    Abstract In this paper, we used time delay feedback to minimize the vibrations of a hybrid Rayleigh–van der Pol–Duffing oscillator. This system is a one-degree-offreedom containing the cubic and fifth nonlinear terms and an external force. We applied the multiple scales method to get the solution from first approximation. Graphically and numerically, we studied the system before and after adding time delay feedback at the primary resonance case (Ω ≌ ω). We used MATLAB program to simulate the efficacy of different parameters and the time delay on the main system. More >

  • Open Access

    ARTICLE

    Preparation and Characterization of Tung Oil Toughened Modified Phenolic Foams with Enhanced Mechanical Properties and Smoke Suppression

    Fei Song1,2, Puyou Jia1,*, Caiying Bo1, Xiaoli Ren1, Lihong Hu1, Yonghong Zhou1,*

    Journal of Renewable Materials, Vol.8, No.5, pp. 535-547, 2020, DOI:10.32604/jrm.2020.09304 - 29 April 2020

    Abstract In this study, we prepared a series of tung oil phenolic foams (TPF) by a one-pot method. The FT-IR and 1 H NMR spectra confirm the successful FriedelCrafts grafting of phenol to the long-chain alkyl group in tung oil. Modified TPFs exhibit enhanced mechanical properties, including compressive and flexural strengths of up to 0.278 ± 0.036 MPa and 0.450 ± 0.017 MPa, respectively, which represent increases of 68.75% and 86.72% over those of pure phenolic foam (PF). SEM spectra reveal the TPF microstructure to have uniform hexagonal cell morphology, narrower cell size distribution, and smaller More >

  • Open Access

    ARTICLE

    Inhibition of Proliferation by Knockdown of Transmembrane (TMEM) 168 in Glioblastoma Cells via Suppression of Wnt/β-Catenin Pathway

    Jie Xu*1, Zhongzhou Su*1, Qiuping Ding, Liang Shen*, Xiaohu Nie*, Xuyan Pan*, Ai Yan*, Renfu Yan*, Yue Zhou*, Liqin Li, Bin Lu*

    Oncology Research, Vol.27, No.7, pp. 819-826, 2019, DOI:10.3727/096504018X15478559215014

    Abstract Human glioblastoma multiforme (GBM) accounts for the majority of human brain gliomas. Several TMEM proteins, such as TMEM 45A, TMEM 97, and TMEM 140, are implicated in human brain gliomas. However, the roles of TMEM168 in human GBM remain poorly understood. Herein we found that mRNA levels of TMEM168 were overexpressed in GBM patients (n=85) when compared with healthy people (n=10), which was also supported by data from The Cancer Genome Atlas (TCGA). Kaplan–Meier analysis of Gene Expression Omnibus dataset GSE16011 suggested that enhanced TMEM168 expression was associated with shorter survival time. To investigate whether and… More >

  • Open Access

    ARTICLE

    Suppression of Ambipolar Conduction in Schottky Barrier Carbon Nanotube Field Effect Transistors: Modeling, Optimization Using Particle Swarm Intelligence, and Fabrication

    P. Reena Monica1,*, V. T. Sreedevi2

    CMES-Computer Modeling in Engineering & Sciences, Vol.119, No.3, pp. 577-591, 2019, DOI:10.32604/cmes.2019.04718

    Abstract A mathematical model and experimental analysis of the impact of oxide thickness on the ambipolar conduction in Schottky Barrier Carbon Nanotubes (CNTs) Field Effect Transistor (SB CNTFETs) is presented. Suppression of ambipolar conduction in SB CNTFETs is imperative in order to establish them as the future of IC technology. The ambipolar nature of SB CNTFETs leads to a great amount of leakage current. Employing a gate oxide dielectric of thickness, tox~50 nm suppresses the ambipolar behavior. In an SB CNTFET, it is the electric field at the source/drain contacts that control the conductance and the band… More >

  • Open Access

    ARTICLE

    Overexpression of Long Noncoding RNA PTENP1 Inhibits Cell Proliferation and Migration via Suppression of miR-19b in Breast Cancer Cells

    Xianbiao Shi, Xiaoqiao Tang, Lei Su

    Oncology Research, Vol.26, No.6, pp. 869-878, 2018, DOI:10.3727/096504017X15123838050075

    Abstract This study aimed to investigate the effect of long noncoding RNA PTENP1 in the development of breast cancer (BC). Quantitative real-time PCR was utilized to determine the expression of PTENP1 in tissues and cell lines. pcDNA3.1 and shRNA were used to over- and low-express PTENP1 in BC cell lines, and miR-19b mimic and inhibitor were utilized to over- and low-express miR-19b. Then the abilities of cell survival, apoptosis, migration, and invasion were assessed in BC cells with different expression levels of PTENP1 and miR-19b. The expression of PTENP1 was significantly downregulated in both BC tissues More >

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