Yequan Wang*, Li Yang*, Jin Zhang*, Ruyue Xue*, Zhenyu Tang*, Wei Huang†, Dianming Jiang†, Xinyan Tang*, Peter Chen‡, KL Paul Sung∗,‡,§,¶
Molecular & Cellular Biomechanics, Vol.7, No.2, pp. 105-114, 2010, DOI:10.3970/mcb.2010.007.105
Abstract The anterior cruciate ligament, posterior cruciate ligament, cartilage and meniscus in human knee joint have poor healing ability. Accumulation of MMPs in the joint fluids due to knee injury has been considered as the main reason. Our previous experiments showed that synovium may be the major regulator of MMPs in joint cavity after injury. In this paper, we used human synoviocytes harvested from synovium to determine whether mechanical injury and inflammatory factors will induce MMP-2 production in synoviocytes. With zymography, we found that mechanical compression increased the MMP-2 production by 23% under 6% compressions, 61% under 12% compression and 109%… More >
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