BENJIANG QIAN1, YOUFENG HUANG2, ZHENQIANG QIU2, XIAOYAN YING3, GUANG YANG3, HUIZHANG LI2,*, JIANMING TAN1,*
BIOCELL, Vol.45, No.3, pp. 599-615, 2021, DOI:10.32604/biocell.2021.014633
Abstract Tet methylcytosine dioxygenase 2 (TET2) acts as an antioncogene that is investigated in different cancers. But
the effects of TET2 in renal cell cancer (RCC) is still known little. Here, quantitative real-time PCR (qRT-PCR), Western
blot, and immunofluorescence were performed to exam gene and protein expression. Cell proliferation was measured
using Cell Counting Kit-8 (CCK-8). Transwell assay was performed to detect cell metastasis viability. Flow cytometry
was performed to analyze the cell cycle and cell apoptosis. The effects of TET2 on RCC growth in vivo was analyzed
using a mouse xenograft model.We found that TET2 and miR-200c were decreased in… More >
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