LING GONG1, HUAJUN YANG1, YING HUANG2, ZHU LI1, JIN NIE3, MENG YE4, PENG XIE5, DAISHUN LIU2,*
BIOCELL, Vol.46, No.4, pp. 1025-1032, 2022, DOI:10.32604/biocell.2022.018248
Abstract Respiratory syncytial virus (RSV) infection is known as a risk factor for chronic obstructive pulmonary disease (COPD). RSV infection induces the upregulation of Toll-like receptor 3 (TLR3). This study aimed to investigate the association of TLR3 with RSV induced acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Serum/sputum samples from AECOPD patients, stable chronic obstructive pulmonary disease (SCOPD) patients, and healthy controls were collected. Nested PCR was used to detect RSV. The lung function parameters were assessed by blood gas and lung function analysis. The expression levels of inflammatory factors in sputum and serum samples were determined by enzyme-linked immunosorbent… More >
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