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    Microglial TRPV1 in epilepsy: Is it druggable for new antiepileptic treatment?


    BIOCELL, Vol.47, No.8, pp. 1689-1701, 2023, DOI:10.32604/biocell.2023.029409

    Abstract Epilepsy is one of the most common neurological diseases worldwide with a high prevalence and unknown pathogenesis. Further, its control is challenging. It is generally accepted that an imbalance between the excitatory and inhibitory properties of the central nervous system (CNS) leads to a large number of abnormally synchronized neuronal discharges in the brain. Transient receptor potential vanilloid protein type 1 (TRPV1) is a non-selective cation channel that contributes to the regulation of the nervous system and influences the excitability of the nervous system. This includes the release of neurotransmitters, action potential generation due to More >

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