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    Thrombospondin 1 Triggers Osteosarcoma Cell Metastasis and Tumor Angiogenesis

    Yue Kui Jian1, Huan Ye Zhu1, Xing Lin Wu, Bo Li

    Oncology Research, Vol.27, No.2, pp. 211-218, 2019, DOI:10.3727/096504018X15208993118389

    Abstract Osteosarcomas, especially those with metastatic or unresectable disease, have limited treatment options. The antitumor effects of pharmacologic inhibitors of angiogenesis in osteosarcomas are hampered in patients by the rapid development of tumor resistance, notably through increased invasiveness and accelerated metastasis. Here we demonstrated that thrombospondin 1 (TSP-1) is a potent inhibitor of the growth and metastasis of the osteosarcoma cell line MG-63. Moreover, we demonstrate that upregulation of TSP-1 facilitated expression of vasculostatin in MG-63 cells. In angiogenesis assays, overexpression of TSP-1 inhibited MG-63 cells and induced tube formation of human umbilical vein endothelial cells (HUVECs) in a CD36-dependent fashion.… More >

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