HYUNG SEOK KIM^*

Oncology Research, Vol.33, No.5, pp. 995-1000, 2025, DOI:10.32604/or.2025.060616 - 18 April 2025

Abstract The discovery of glycosylated RNA molecules, known as glycoRNAs, introduces a novel dimension to cellular biology. This commentary explores the transformative findings surrounding glycoRNAs, emphasizing their unique roles in cancer progression and the therapeutic opportunities they present. GlycoRNAs, through interactions with lectins and immune receptors, may contribute to tumor immune evasion. Moreover, the therapeutic potential of this emerging knowledge includes interventions targeting glycoRNA synthesis and modulation of associated signaling pathways. By highlighting these critical insights, this commentary aims to encourage the development of innovative strategies that could improve cancer prognosis and treatment. More >

GAVIN M. ANCHONDO, KYRA PARKER, ALEXIS BRUCE, ELIZABETH CORTEZ, LE SU^*

Oncology Research, Vol.33, No.5, pp. 1001-1005, 2025, DOI:10.32604/or.2025.060573 - 18 April 2025

Abstract Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX. The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma, and it has thus been commonly accepted that disruption of SS18-SSX function represents a therapeutic means of treating synovial sarcoma, but emerging evidence suggests that upon depletion of SS18-SSX, an anti-apoptotic signal surprisingly arises to protect synovial sarcoma cell survival. In this article, we discuss the controversial roles of SS18-SSX’s transcriptional activity in synovial sarcoma biology and outline a synergistic strategy for overcoming the resistance of More > Graphic Abstract

MOEKA NAKASHIMA, NAOKO SUGA, AKARI FUKUMOTO, SAYURI YOSHIKAWA, SATORU MATSUDA^*

Oncology Research, Vol.33, No.5, pp. 1007-1017, 2025, DOI:10.32604/or.2025.059657 - 18 April 2025

Abstract Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation, invasion, metastasis, and/or recurrence of their malignancies. In particular, cancer stem cells (CSCs) within these tumors might be responsible for the property of invasiveness and/or therapies-resistance. CSCs are a self-renewing, awfully tumorigenic subpopulation of cancer cells, which are notorious for strong chemoresistance and are frequently responsible the aggravated invasion, metastasis, and/or recurrence. Developing targeting therapies against CSCs, therefore, may be deliberated a more encouraging mission for the greater cancer therapy. Innovation for a more potent anti-CSC treatment has been required as soon as possible.… More > Graphic Abstract

Oncology Research Editorial Office

Oncology Research, Vol.33, No.5, pp. 1253-1253, 2025, DOI:10.32604/or.2024.056916 - 18 April 2025

Abstract This article has no abstract. More >

Jianyin Tang, Zhenglin Yu^*, Changshun Shao

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2829-2850, 2025, DOI:10.32604/cmc.2025.063287 - 16 April 2025

Abstract In the field of automated fruit harvesting, precise and efficient fruit target recognition and localization play a pivotal role in enhancing the efficiency of harvesting robots. However, this domain faces two core challenges: firstly, the dynamic nature of the automatic picking process requires fruit target detection algorithms to adapt to multi-view characteristics, ensuring effective recognition of the same fruit from different perspectives. Secondly, fruits in natural environments often suffer from interference factors such as overlapping, occlusion, and illumination fluctuations, which increase the difficulty of image capture and recognition. To address these challenges, this study conducted… More >

Emmanuel Mago¹, Jiayi Xu¹, Dan Weng^1,*, Yan Pan^2,*

BIOCELL, Vol.49, No.3, pp. 381-398, 2025, DOI:10.32604/biocell.2025.059432 - 31 March 2025

Abstract Z-DNA binding protein 1 (ZBP1) has emerged as a critical player in cancer biology, functioning as a cytosolic nucleic acid sensor that triggers PANoptosis, a form of programmed cell death that integrates pyroptosis, apoptosis, and necroptosis. Although ZBP1 was initially recognized for its role in antiviral defense, recent research has highlighted its importance in the tumor microenvironment (TME), where it is essential for suppressing tumor growth and proliferation. This review explores the multifaceted role of ZBP1 in various cancer types, emphasizing its ability to detect Z-nucleic acids and double-stranded RNAs, leading to the initiation of… More >

Lijuan Zhang^1,2, Xiaoyu Wang^1,2, Songtao Zhang³, Yutong Jiang^4,*, Dongming Li¹, Weichen Sun⁴

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1219-1237, 2025, DOI:10.32604/cmc.2025.059856 - 26 March 2025

Abstract In this paper, a reasoning enhancement method based on RGCN (Relational Graph Convolutional Network) is proposed to improve the detection capability of UAV (Unmanned Aerial Vehicle) on fast-moving military targets in urban battlefield environments. By combining military images with the publicly available VisDrone2019 dataset, a new dataset called VisMilitary was built and multiple YOLO (You Only Look Once) models were tested on it. Due to the low confidence problem caused by fuzzy targets, the performance of traditional YOLO models on real battlefield images decreases significantly. Therefore, we propose an improved RGCN inference model, which improves More >

AMJAD YOUSUF¹, NAJEEB ULLAH KHAN^2,*

Oncology Research, Vol.33, No.4, pp. 851-861, 2025, DOI:10.32604/or.2025.058956 - 19 March 2025

Abstract Breast cancer is a significant global concern, with limited effective treatment options. Therefore, therapies with high efficacy and low complications, unlike the existing chemotherapies, are urgently required. To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction. This review aims to investigate the efficacy of MDM2 inhibition in restoring TP53 activity in breast cancer cells, as evidenced by clinical studies, reviews, and trials. TP53 is a tumor suppressor and MDM2 facilitates proteasomal degradation of TP53. MDM2 and TP53 activity More > Graphic Abstract

JIAHENG WEI¹, LIANGMING ZHU^2,*

Oncology Research, Vol.33, No.4, pp. 863-872, 2025, DOI:10.32604/or.2024.054201 - 19 March 2025

Abstract Lung cancer is one of the main causes of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) being the most prevalent histological subtype of lung cancer. Glutathione peroxidase 4 (GPX4) is a crucial antioxidant enzyme that plays a role in regulating ferroptosis. It is also involved in a wide variety of biological processes, such as tumor cell growth invasion, migration, and resistance to drugs. This study comprehensively examined the role of GPX4 in NSCLC and investigated the clinical feasibility of targeting GPX4 for NSCLC treatment. We discovered that GPX4 influences the progression of NSCLC More >

ZHIZHENG ZHANG^1,#, TAO LI^2,#, YUAN LI³, XI WANG⁴, HAO LIU⁵, XINYU SHEN⁵, ANN XU⁶, TIANSONG XIA^1,*, BO XU^7,*

Oncology Research, Vol.33, No.4, pp. 811-819, 2025, DOI:10.32604/or.2024.050505 - 19 March 2025

Abstract Background: Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy. Methods: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as “breast cancer stem cells,” “immunotherapy,” “gene therapy,” and “cell therapy.” Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells. Results: Breast cancer stem cells exhibit unique properties More >