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  • Open Access

    REVIEW

    MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma: potential therapeutic targets and diagnostic/prognostic markers and web based tools

    ELHAM SHAKIBA1, SETI BOROOMAND2, SIMA KHERADMAND KIA3, MEHDI HEDAYATI4,*

    Oncology Research, Vol.32, No.6, pp. 1011-1019, 2024, DOI:10.32604/or.2024.049235

    Abstract This review aimed to describe the inculpation of microRNAs (miRNAs) in thyroid cancer (TC) and its subtypes, mainly medullary thyroid carcinoma (MTC), and to outline web-based tools and databases for bioinformatics analysis of miRNAs in TC. Additionally, the capacity of miRNAs to serve as therapeutic targets and biomarkers in TC management will be discussed. This review is based on a literature search of relevant articles on the role of miRNAs in TC and its subtypes, mainly MTC. Additionally, web-based tools and databases for bioinformatics analysis of miRNAs in TC were identified and described. MiRNAs can… More > Graphic Abstract

    MicroRNAs in thyroid cancer with focus on medullary thyroid carcinoma: potential therapeutic targets and diagnostic/prognostic markers and web based tools

  • Open Access

    ARTICLE

    Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

    YUE ZHANG1,#, WENYU YANG1,#, XIAOWANG HAN1,#, YUE QIAO1, HAITAO WANG2, TING CHEN1, TIANYING LI1, WEN-BIN OU1,*

    Oncology Research, Vol.32, No.6, pp. 1119-1128, 2024, DOI:10.32604/or.2024.045025

    Abstract It has been shown that the high expression of human epididymis protein 4 (HE4) in most lung cancers is related to the poor prognosis of patients, but the mechanism of pathological transformation of HE4 in lung cancer is still unclear. The current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma (LUAD). Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies, and through analysis of The Cancer Genome Atlas (TCGA) dataset. Frequent HE4 overexpression was demonstrated in LUAD, but not in lung squamous… More >

  • Open Access

    ARTICLE

    Highly Differentiated Target Detection under Extremely Low-Light Conditions Based on Improved YOLOX Model

    Haijian Shao1,2,*, Suqin Lei1, Chenxu Yan3, Xing Deng1, Yunsong Qi1

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1507-1537, 2024, DOI:10.32604/cmes.2024.050140

    Abstract This paper expounds upon a novel target detection methodology distinguished by its elevated discriminatory efficacy, specifically tailored for environments characterized by markedly low luminance levels. Conventional methodologies struggle with the challenges posed by luminosity fluctuations, especially in settings characterized by diminished radiance, further exacerbated by the utilization of suboptimal imaging instrumentation. The envisioned approach mandates a departure from the conventional YOLOX model, which exhibits inadequacies in mitigating these challenges. To enhance the efficacy of this approach in low-light conditions, the dehazing algorithm undergoes refinement, effecting a discerning regulation of the transmission rate at the pixel… More > Graphic Abstract

    Highly Differentiated Target Detection under Extremely Low-Light Conditions Based on Improved YOLOX Model

  • Open Access

    ARTICLE

    Sensitivity Analysis of Electromagnetic Scattering from Dielectric Targets with Polynomial Chaos Expansion and Method of Moments

    Yujing Ma1,4, Zhongwang Wang2, Jieyuan Zhang3, Ruijin Huo1,4, Xiaohui Yuan1,4,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 2079-2102, 2024, DOI:10.32604/cmes.2024.048488

    Abstract In this paper, an adaptive polynomial chaos expansion method (PCE) based on the method of moments (MoM) is proposed to construct surrogate models for electromagnetic scattering and further sensitivity analysis. The MoM is applied to accurately solve the electric field integral equation (EFIE) of electromagnetic scattering from homogeneous dielectric targets. Within the bistatic radar cross section (RCS) as the research object, the adaptive PCE algorithm is devoted to selecting the appropriate order to construct the multivariate surrogate model. The corresponding sensitivity results are given by the further derivative operation, which is compared with those of More >

  • Open Access

    ARTICLE

    Image Segmentation-P300 Selector: A Brain–Computer Interface System for Target Selection

    Hang Sun, Changsheng Li*, He Zhang

    CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2505-2522, 2024, DOI:10.32604/cmc.2024.049898

    Abstract Brain–computer interface (BCI) systems, such as the P300 speller, enable patients to express intentions without necessitating extensive training. However, the complexity of operational instructions and the slow pace of character spelling pose challenges for some patients. In this paper, an image segmentation P300 selector based on YOLOv7-mask and DeepSORT is proposed. The proposed system utilizes a camera to capture real-world objects for classification and tracking. By applying predefined stimulation rules and object-specific masks, the proposed system triggers stimuli associated with the objects displayed on the screen, inducing the generation of P300 signals in the patient’s… More >

  • Open Access

    ARTICLE

    MAPK9 as a therapeutic target: unveiling ferroptosis in localized prostate cancer progression

    CHENG-GONG LUO1,2,#, JIAO ZHANG1,#, YUN-ZHAO AN1, XUAN LIU1, SHUAI-JIE LI1, WEI ZHANG1, KAI LI1, XU ZHAO1, DONG-BO YUAN1, LING-YUE AN1, WEI CHEN2, YE TIAN1,*, BIN XU1,*

    BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878

    Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted… More >

  • Open Access

    ARTICLE

    Securing Forwarding Layers from Eavesdropping Attacks Using Proactive Approaches

    Jiajun Yan, Ying Zhou*, Anchen Dai, Tao Wang

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 563-580, 2024, DOI:10.32604/cmc.2024.048922

    Abstract As an emerging network paradigm, the software-defined network (SDN) finds extensive application in areas such as smart grids, the Internet of Things (IoT), and edge computing. The forwarding layer in software-defined networks is susceptible to eavesdropping attacks. Route hopping is a moving target defense (MTD) technology that is frequently employed to resist eavesdropping attacks. In the traditional route hopping technology, both request and reply packets use the same hopping path. If an eavesdropping attacker monitors the nodes along this path, the risk of 100% data leakage becomes substantial. In this paper, we present an effective… More >

  • Open Access

    ARTICLE

    A Layered Energy-Efficient Multi-Node Scheduling Mechanism for Large-Scale WSN

    Xue Zhao, Shaojun Tao, Hongying Tang, Jiang Wang*, Baoqing Li*

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1335-1351, 2024, DOI:10.32604/cmc.2024.047996

    Abstract In recent years, target tracking has been considered one of the most important applications of wireless sensor network (WSN). Optimizing target tracking performance and prolonging network lifetime are two equally critical objectives in this scenario. The existing mechanisms still have weaknesses in balancing the two demands. The proposed heuristic multi-node collaborative scheduling mechanism (HMNCS) comprises cluster head (CH) election, pre-selection, and task set selection mechanisms, where the latter two kinds of selections form a two-layer selection mechanism. The CH election innovatively introduces the movement trend of the target and establishes a scoring mechanism to determine More >

  • Open Access

    REVIEW

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

    KARAN WADHWA1, PAYAL CHAUHAN1, SHOBHIT KUMAR2, RAKESH PAHWA3,*, RAVINDER VERMA4, RAJAT GOYAL5, GOVIND SINGH1, ARCHANA SHARMA6, NEHA RAO3, DEEPAK KAUSHIK1,*

    Oncology Research, Vol.32, No.5, pp. 877-897, 2024, DOI:10.32604/or.2024.047278

    Abstract Background: Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective: Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods: Relevant literature for this manuscript has been collected from a comprehensive More > Graphic Abstract

    Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

  • Open Access

    REVIEW

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

    NILAM BHUSARE, MAUSHMI KUMAR*

    Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

    Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways… More > Graphic Abstract

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

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