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  • Open Access

    COMMENTARY

    GlycoRNA: A new player in cellular communication

    HYUNG SEOK KIM*

    Oncology Research, Vol.33, No.5, pp. 995-1000, 2025, DOI:10.32604/or.2025.060616 - 18 April 2025

    Abstract The discovery of glycosylated RNA molecules, known as glycoRNAs, introduces a novel dimension to cellular biology. This commentary explores the transformative findings surrounding glycoRNAs, emphasizing their unique roles in cancer progression and the therapeutic opportunities they present. GlycoRNAs, through interactions with lectins and immune receptors, may contribute to tumor immune evasion. Moreover, the therapeutic potential of this emerging knowledge includes interventions targeting glycoRNA synthesis and modulation of associated signaling pathways. By highlighting these critical insights, this commentary aims to encourage the development of innovative strategies that could improve cancer prognosis and treatment. More >

  • Open Access

    VIEWPOINT

    The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma

    GAVIN M. ANCHONDO, KYRA PARKER, ALEXIS BRUCE, ELIZABETH CORTEZ, LE SU*

    Oncology Research, Vol.33, No.5, pp. 1001-1005, 2025, DOI:10.32604/or.2025.060573 - 18 April 2025

    Abstract Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX. The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma, and it has thus been commonly accepted that disruption of SS18-SSX function represents a therapeutic means of treating synovial sarcoma, but emerging evidence suggests that upon depletion of SS18-SSX, an anti-apoptotic signal surprisingly arises to protect synovial sarcoma cell survival. In this article, we discuss the controversial roles of SS18-SSX’s transcriptional activity in synovial sarcoma biology and outline a synergistic strategy for overcoming the resistance of More > Graphic Abstract

    The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma

  • Open Access

    REVIEW

    Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy

    MOEKA NAKASHIMA, NAOKO SUGA, AKARI FUKUMOTO, SAYURI YOSHIKAWA, SATORU MATSUDA*

    Oncology Research, Vol.33, No.5, pp. 1007-1017, 2025, DOI:10.32604/or.2025.059657 - 18 April 2025

    Abstract Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation, invasion, metastasis, and/or recurrence of their malignancies. In particular, cancer stem cells (CSCs) within these tumors might be responsible for the property of invasiveness and/or therapies-resistance. CSCs are a self-renewing, awfully tumorigenic subpopulation of cancer cells, which are notorious for strong chemoresistance and are frequently responsible the aggravated invasion, metastasis, and/or recurrence. Developing targeting therapies against CSCs, therefore, may be deliberated a more encouraging mission for the greater cancer therapy. Innovation for a more potent anti-CSC treatment has been required as soon as possible.… More > Graphic Abstract

    Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy

  • Open Access

    RETRACTION

    Retraction: Swainsonine inhibits invasion and the EMT process in esophageal carcinoma cells by targeting twist1

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.5, pp. 1253-1253, 2025, DOI:10.32604/or.2024.056916 - 18 April 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    TransSSA: Invariant Cue Perceptual Feature Focused Learning for Dynamic Fruit Target Detection

    Jianyin Tang, Zhenglin Yu*, Changshun Shao

    CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2829-2850, 2025, DOI:10.32604/cmc.2025.063287 - 16 April 2025

    Abstract In the field of automated fruit harvesting, precise and efficient fruit target recognition and localization play a pivotal role in enhancing the efficiency of harvesting robots. However, this domain faces two core challenges: firstly, the dynamic nature of the automatic picking process requires fruit target detection algorithms to adapt to multi-view characteristics, ensuring effective recognition of the same fruit from different perspectives. Secondly, fruits in natural environments often suffer from interference factors such as overlapping, occlusion, and illumination fluctuations, which increase the difficulty of image capture and recognition. To address these challenges, this study conducted… More >

  • Open Access

    REVIEW

    Involvement of ZBP1 in Cancer and Its Potential Therapeutic Target Effects

    Emmanuel Mago1, Jiayi Xu1, Dan Weng1,*, Yan Pan2,*

    BIOCELL, Vol.49, No.3, pp. 381-398, 2025, DOI:10.32604/biocell.2025.059432 - 31 March 2025

    Abstract Z-DNA binding protein 1 (ZBP1) has emerged as a critical player in cancer biology, functioning as a cytosolic nucleic acid sensor that triggers PANoptosis, a form of programmed cell death that integrates pyroptosis, apoptosis, and necroptosis. Although ZBP1 was initially recognized for its role in antiviral defense, recent research has highlighted its importance in the tumor microenvironment (TME), where it is essential for suppressing tumor growth and proliferation. This review explores the multifaceted role of ZBP1 in various cancer types, emphasizing its ability to detect Z-nucleic acids and double-stranded RNAs, leading to the initiation of… More >

  • Open Access

    ARTICLE

    Target Detection-Oriented RGCN Inference Enhancement Method

    Lijuan Zhang1,2, Xiaoyu Wang1,2, Songtao Zhang3, Yutong Jiang4,*, Dongming Li1, Weichen Sun4

    CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1219-1237, 2025, DOI:10.32604/cmc.2025.059856 - 26 March 2025

    Abstract In this paper, a reasoning enhancement method based on RGCN (Relational Graph Convolutional Network) is proposed to improve the detection capability of UAV (Unmanned Aerial Vehicle) on fast-moving military targets in urban battlefield environments. By combining military images with the publicly available VisDrone2019 dataset, a new dataset called VisMilitary was built and multiple YOLO (You Only Look Once) models were tested on it. Due to the low confidence problem caused by fuzzy targets, the performance of traditional YOLO models on real battlefield images decreases significantly. Therefore, we propose an improved RGCN inference model, which improves More >

  • Open Access

    REVIEW

    Targeting MDM2-p53 interaction for breast cancer therapy

    AMJAD YOUSUF1, NAJEEB ULLAH KHAN2,*

    Oncology Research, Vol.33, No.4, pp. 851-861, 2025, DOI:10.32604/or.2025.058956 - 19 March 2025

    Abstract Breast cancer is a significant global concern, with limited effective treatment options. Therefore, therapies with high efficacy and low complications, unlike the existing chemotherapies, are urgently required. To address this issue, advances have been made in therapies targeting molecular pathways related to the murine double minute 2 proto-oncogene (MDM2)-tumor proteinp53 (TP53) interaction. This review aims to investigate the efficacy of MDM2 inhibition in restoring TP53 activity in breast cancer cells, as evidenced by clinical studies, reviews, and trials. TP53 is a tumor suppressor and MDM2 facilitates proteasomal degradation of TP53. MDM2 and TP53 activity More > Graphic Abstract

    Targeting MDM2-p53 interaction for breast cancer therapy

  • Open Access

    REVIEW

    The role of glutathione peroxidase 4 in the progression, drug resistance, and targeted therapy of non-small cell lung cancer

    JIAHENG WEI1, LIANGMING ZHU2,*

    Oncology Research, Vol.33, No.4, pp. 863-872, 2025, DOI:10.32604/or.2024.054201 - 19 March 2025

    Abstract Lung cancer is one of the main causes of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) being the most prevalent histological subtype of lung cancer. Glutathione peroxidase 4 (GPX4) is a crucial antioxidant enzyme that plays a role in regulating ferroptosis. It is also involved in a wide variety of biological processes, such as tumor cell growth invasion, migration, and resistance to drugs. This study comprehensively examined the role of GPX4 in NSCLC and investigated the clinical feasibility of targeting GPX4 for NSCLC treatment. We discovered that GPX4 influences the progression of NSCLC More >

  • Open Access

    REVIEW

    Cancer stem cell specificity as new targets in breast tumor treatment

    ZHIZHENG ZHANG1,#, TAO LI2,#, YUAN LI3, XI WANG4, HAO LIU5, XINYU SHEN5, ANN XU6, TIANSONG XIA1,*, BO XU7,*

    Oncology Research, Vol.33, No.4, pp. 811-819, 2025, DOI:10.32604/or.2024.050505 - 19 March 2025

    Abstract Background: Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy. Methods: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as “breast cancer stem cells,” “immunotherapy,” “gene therapy,” and “cell therapy.” Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells. Results: Breast cancer stem cells exhibit unique properties More >

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