Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077270 - 30 December 2025

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.077269 - 30 December 2025

Abstract This article has no abstract. More >

Se Ha Jang^1,2,#, Hyung Seok Kim^3,#, Jung Woo Eun^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.072240 - 30 December 2025

Abstract Hepatocellular carcinoma (HCC) remains one of the most prevalent and lethal malignancies worldwide. Long non-coding RNAs (lncRNAs) have emerged as crucial regulators of gene expression and cancer progression, yet the functional diversity of RP11-derived lncRNAs—originally mapped to bacterial artificial chromosome (BAC) clones from the Roswell Park Cancer Institute—has only recently begun to be appreciated. This mini-review aims to systematically synthesize current findings on RP11-derived lncRNAs in HCC, outlining their genomic origins, molecular mechanisms, and biological significance. We highlight their roles in metabolic reprogramming, microRNA network modulation, and tumor progression, as well as their diagnostic and More >

Dongchi Cai^1,2,#, Jialin Ji^3,#, Chunhui Yang^1,*, Hong Cai^1,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.071152 - 30 December 2025

Abstract Metabolic reprogramming involving branched-chain amino acids (BCAAs)—leucine, isoleucine, and valine—is increasingly recognized as pivotal in cancer progression, metastasis, and immune modulation. This review comprehensively explores how cancer cells rewire BCAA metabolism to enhance proliferation, survival, and therapy resistance. Tumors manipulate BCAA uptake and catabolism via high expression of transporters like L-type amino acid transporter 1 (LAT1) and enzymes including branched chain amino acid transaminase 1(BCAT1), branched chain amino acid transaminase 2 (BCAT2), branched-chain alpha-keto acid dehydrogenase (BCKDH), and branched chain alpha-keto acid dehydrogenase kinase (BCKDK). These alterations sustain energy production, biosynthesis, redox homeostasis, and oncogenic… More >

Lv Ling^1,#, Minying Lu^2,#, Ling Ye³, Yuanhang Chen², Sheng Lin², Jun Yang², Yu Rong^2,*, Guixiong Wu^4,*

Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.069889 - 30 December 2025

Abstract Background: A significant proportion of patients still cannot benefit from existing targeted therapies and immunotherapies, making the search for new treatment strategies extremely urgent. In this study, we combined integrate public data analysis with experimental validation to identify novel prognostic biomarkers and therapeutic targets for lung adenocarcinoma (LUAD). Methods: We analyzed RNA and protein databases to assess the expression levels of cytochrome C oxidase 5B (COX5B) in LUAD. Several computational algorithms were employed to investigate the relationship between COX5B and immune infiltration in LUAD. To further elucidate the role of COX5B in LUAD, we utilized… More > Graphic Abstract

Dike Chen^1,2,3, Zhiyong Qin², Ji Zhang², Hongyuan Wang^1,2,*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-17, 2026, DOI:10.32604/cmc.2025.072494 - 09 December 2025

Abstract To address the challenges of small target detection and significant scale variations in unmanned aerial vehicle (UAV) aerial imagery, which often lead to missed and false detections, we propose Multi-scale Feature Fusion YOLO (MFF-YOLO), an enhanced algorithm based on YOLOv8s. Our approach introduces a Multi-scale Feature Fusion Strategy (MFFS), comprising the Multiple Features C2f (MFC) module and the Scale Sequence Feature Fusion (SSFF) module, to improve feature integration across different network levels. This enables more effective capture of fine-grained details and sequential multi-scale features. Furthermore, we incorporate Inner-CIoU, an improved loss function that uses auxiliary More >

Jay Barach^*

CMC-Computers, Materials & Continua, Vol.86, No.2, pp. 1-23, 2026, DOI:10.32604/cmc.2025.071705 - 09 December 2025

Abstract Human Resource (HR) operations increasingly rely on cloud-based platforms that provide hiring, payroll, employee management, and compliance services. These systems, typically built on multi-tenant microservice architectures, offer scalability and efficiency but also expand the attack surface for adversaries. Ransomware has emerged as a leading threat in this domain, capable of halting workflows and exposing sensitive employee records. Traditional defenses such as static hardening and signature-based detection often fail to address the dynamic requirements of HR Software as a Service (SaaS), where continuous availability and privacy compliance are critical. This paper presents a Moving Target Defense… More >

Jianhua Yang^*, Zhiwei Lv, Changling Huo

CMC-Computers, Materials & Continua, Vol.86, No.1, pp. 1-18, 2026, DOI:10.32604/cmc.2025.068442 - 10 November 2025

Abstract Aiming at the scale adaptation of automatic driving target detection algorithms in low illumination environments and the shortcomings in target occlusion processing, this paper proposes a YOLO-LKSDS automatic driving detection model. Firstly, the Contrast-Limited Adaptive Histogram Equalisation (CLAHE) image enhancement algorithm is improved to increase the image contrast and enhance the detailed features of the target; then, on the basis of the YOLOv5 model, the Kmeans++ clustering algorithm is introduced to obtain a suitable anchor frame, and SPPELAN spatial pyramid pooling is improved to enhance the accuracy and robustness of the model for multi-scale target… More >

Xingkang Jiang^*, Jing Tian, Yong Xu

Canadian Journal of Urology, Vol.32, No.6, pp. 539-540, 2025, DOI:10.32604/cju.2025.073363 - 30 December 2025

Abstract This article has no abstract. More >

Abdul Baseet Arham¹, John M. Rieth², Michael A. O’Donnell^3,*

Canadian Journal of Urology, Vol.32, No.6, pp. 605-620, 2025, DOI:10.32604/cju.2025.063632 - 30 December 2025

Abstract Background: Genitourinary (GU) sarcomas are rare soft tissue malignancies, comprising around 2% of all GU cancers. Due to their rarity, limited data exist on optimal management and long-term outcomes. This study presents a 25-year single-institution experience, evaluating clinical presentation, treatment strategies, and survival outcomes, aims to identify trends over time and potential predictors of prognosis. Methods: A retrospective review was conducted of patients aged ≥18 years diagnosed with GU sarcomas at the University of Iowa Hospitals and Clinics (1998–2023). Data on tumor subtype, staging, histopathology, treatment modalities, and survival outcomes were analyzed. Kaplan-Meier analysis estimated… More >