QIUQIANG CHEN^1,*, XUEJUN GUO², WENXUE MA^3,*

Oncology Research, Vol.32, No.1, pp. 49-60, 2024, DOI:10.32604/or.2023.042383

Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and… More > Graphic Abstract

Yue Cui^1,*, Liyuan Wang², Jian Wu¹, Haisheng Liu¹, Di Wu¹

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.1, pp. 165-177, 2024, DOI:10.32604/fdmp.2023.030311

Abstract This study aims to improve the performances of the high-pressure water descaling technology used in steel hot rolling processes. In particular, a 2050 mm hot rolling line is considered, and the problem is investigated by means of a fluid–structure interaction (FSI) method by which the descaling effect produced by rolling coils with different section sizes is examined. Assuming a flat fan-shaped nozzle at the entrance of the R1R2 roughing mill, the out- flow field characteristics and the velocity distribution curve on the strike line (at a target distance of 30–120 mm) are determined. It is found that the velocity in… More >

ELYN AMIELA SALLEH¹, YEONG YEH LEE², ANDEE DZULKARNAEN ZAKARIA³, NUR ASYILLA CHE JALIL⁴, MARAHAINI MUSA^1,*

BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541

Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed to help in determining patient… More > Graphic Abstract

SHENGJIE SONG, ZHIZHOU SHI^*

BIOCELL, Vol.47, No.10, pp. 2207-2215, 2023, DOI:10.32604/biocell.2023.027677

Abstract Metabolic reprogramming frequently occurs in the majority of cancers, wherein fatty acid oxidation (FAO) is usually induced and serves as a compensatory mechanism to improve energy consumption. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO and is widely involved in tumor growth, metastasis, and chemo-/radio-resistance. This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis, including in proliferation and tumor growth, invasion and metastasis, and the tumor microenvironment. Importantly, CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target,… More > Graphic Abstract

Tengda Li, Gang Wang, Qiang Fu^*, Xiangke Guo, Minrui Zhao, Xiangyu Liu

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3499-3522, 2023, DOI:10.32604/cmc.2023.041253

Abstract Aiming at the problems of traditional dynamic weapon-target assignment algorithms in command decision-making, such as large computational amount, slow solution speed, and low calculation accuracy, combined with deep reinforcement learning theory, an improved Deep Deterministic Policy Gradient algorithm with dual noise and prioritized experience replay is proposed, which uses a double noise mechanism to expand the search range of the action, and introduces a priority experience playback mechanism to effectively achieve data utilization. Finally, the algorithm is simulated and validated on the ground-to-air countermeasures digital battlefield. The results of the experiment show that, under the framework of the deep neural… More >

Zhenyu Huang^1,2, Gun Li², Xudong Sun¹, Yong Chen¹, Jie Sun¹, Zhangsong Ni^1,*, Yang Yang^1,*

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 3219-3238, 2023, DOI:10.32604/cmc.2023.039489

Abstract Onboard visual object tracking in unmanned aerial vehicles (UAVs) has attracted much interest due to its versatility. Meanwhile, due to high precision, Siamese networks are becoming hot spots in visual object tracking. However, most Siamese trackers fail to balance the tracking accuracy and time within onboard limited computational resources of UAVs. To meet the tracking precision and real-time requirements, this paper proposes a Siamese dense pixel-level network for UAV object tracking named SiamDPL. Specifically, the Siamese network extracts features of the search region and the template region through a parameter-shared backbone network, then performs correlation matching to obtain the candidate… More >

Huaixi Xing^*, Qinghua Xing

CMC-Computers, Materials & Continua, Vol.76, No.3, pp. 2685-2705, 2023, DOI:10.32604/cmc.2023.036223

Abstract With the advancement of combat equipment technology and combat concepts, new requirements have been put forward for air defense operations during a group target attack. To achieve high-efficiency and low-loss defensive operations, a reasonable air defense weapon assignment strategy is a key step. In this paper, a multi-objective and multi-constraints weapon target assignment (WTA) model is established that aims to minimize the defensive resource loss, minimize total weapon consumption, and minimize the target residual effectiveness. An optimization framework of air defense weapon mission scheduling based on the multi-objective artificial bee colony (MOABC) algorithm is proposed. The solution for point-to-point saturated… More >

WEI LU^1,*, KAN GUO², DIANMEI XI¹, ZHAOXIA XIA¹

BIOCELL, Vol.47, No.9, pp. 1995-2008, 2023, DOI:10.32604/biocell.2023.024591

Abstract Background: Mesenchymal stem cell (MSC)-derived exosomes are closely related to pyroptosis in diabetic nephropathy (DN). This study aimed to explore the protective effect of exosomal miR-30a-5p on podocyte pyroptosis in DN. Methods: Streptozotocin was used to establish the mouse model of DN. Human bone marrow MSC-derived exosomes were extracted and identified via transmission electron microscopy, nanoparticle tracking analysis, and western blotting. MiR-30a-5p mimics and non-control (NC) mimics were transfected into MSCs and podocytes, and exosomes were isolated from the MSCs. High glucose (HG)-induced podocyte model was established to determine the effect of exosomal miR-30a-5p on pyroptosis and inflammation in vitro.… More >

LU SUN^1,2, HUAICHENG TAN¹, TING YU³, RUICHAO LIANG^4,*

Oncology Research, Vol.31, No.6, pp. 967-988, 2023, DOI:10.32604/or.2023.042309

Abstract Lung adenocarcinoma (LUAD) is the most common and deadliest subtype of lung cancer. To select more targeted and effective treatments for individuals, further advances in classifying LUAD are urgently needed. The number, type, and function of T cells in the tumor microenvironment (TME) determine the progression and treatment response of LUAD. Long noncoding RNAs (lncRNAs), may regulate T cell differentiation, development, and activation. Thus, our aim was to identify T cell-related lncRNAs (T cell-Lncs) in LUAD and to investigate whether T cell-Lncs could serve as potential stratifiers and therapeutic targets. Seven T cell-Lncs were identified to further establish the T… More >

MAKOTO KAWATANI^1,2,*, HARUMI AONO², SAYOKO HIRANUMA³, TAKESHI SHIMIZU³, MAKOTO MUROI^1,2, TOSHIHIKO NOGAWA⁴, TOMOKAZU OHISHI⁵, SHUN-ICHI OHBA⁵, MANABU KAWADA⁵, KANAMI YAMAZAKI⁶, SHINGO DAN⁶, NAOSHI DOHMAE¹, HIROYUKI OSADA^2,7,*

Oncology Research, Vol.31, No.6, pp. 833-844, 2023, DOI:10.32604/or.2023.030241

Abstract Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases. This study presents the identification of a potent DHODH inhibitor by proteomic profiling. Cell-based screening revealed that NPD723, which is reduced to H-006 in cells, strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells. H-006 also suppressed the growth of various cancer cells. Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors. H-006 potently inhibited human DHODH activity in vitro, whereas NPD723 was approximately… More >