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Crossroads: Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis

YANG LI1,2, JIAN LIU1,3,*, YUEDI HU1,2, CHENGZHI CONG1,2, YIMING CHEN1,2, QIAO ZHOU1,2

1 Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, 230031, China
2 First Clinical Medical School, Anhui University of Chinese Medicine, Hefei, 230031, China
3 Institute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, 230031, China

* Corresponding Author: JIAN LIU. Email: email

(This article belongs to this Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)

BIOCELL 2024, 48(1), 9-19. https://doi.org/10.32604/biocell.2023.045862

Abstract

Rheumatoid arthritis (RA) is a prevalent autoimmune disease whose main features include chronic synovial inflammation, bone destruction, and joint degeneration. Neutrophils are often considered to be the first responders to inflammation and are a key presence in the inflammatory milieu of RA. Neutrophil extracellular traps (NETs), a meshwork of DNA-histone complexes and proteins released by activated neutrophils, are widely involved in the pathophysiology of autoimmune diseases, especially RA, in addition to playing a key role in the neutrophil innate immune response. NETs have been found to be an important source of citrullinated autoantigen antibodies and inflammatory factor release, which can activate RA synovial fibroblasts (FLS) and cause joint damage. This article reviews the role of NETs in the pathophysiology of RA, demonstrating the application of multiple molecules with various therapies, with a view to informing the discovery and development of novel biomarkers and therapeutic targets for RA.

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Crossroads: Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis

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Cite This Article

LI, Y., LIU, J., HU, Y., CONG, C., CHEN, Y. et al. (2024). Crossroads: Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis. BIOCELL, 48(1), 9–19.



cc This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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