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Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine

Submission Deadline: 31 December 2023 (closed)

Guest Editors

Prof. Dr. Anna Maria Lavezzi, University of Milan, Italy. anna.lavezzi@unimi.it


Prof. Dr. Riffat Mehboob, Lahore Medical Research Center, Pakistan. mehboob.riffat@gmail.com

Summary

A biomarker is a measurable indicator that substitutes for and ideally predicts a clinically relevant endpoint or intermediate outcome that is difficult to observe directly. It plays a crucial role in precision medicine, particularly as predictive biomarkers. Clinical biomarkers offer a more cost-effective and efficient alternative to directly measuring the final clinical endpoint, and they have various applications in disease screening, diagnosis, monitoring, and individualized therapeutic interventions. Understanding the pathophysiological relationship between a biomarker and the clinical endpoint is essential. Good biomarkers should be reliable, show little variability, have a significant signal-to-noise ratio, and respond promptly to changes in the condition or its treatment.

 

Biomarkers are vital for clinical and experimental diagnostics, enabling the detection and quantification of diseases. Rapid detection of disease-specific biomarkers is crucial for early diagnosis and subsequent treatments. Various detection techniques are available for identifying disease biomarkers. In evidence-based medicine, novel molecular biomarkers have the potential to improve disease diagnosis, treatment, and health outcomes while reducing the socio-economic impact of diseases. Biomarkers are extensively used in cancer treatment to monitor disease progression, drug response, relapses, and drug resistance. However, despite extensive research efforts, the identification of biomarkers for early detection, especially in cancer, has been challenging.

 

This Special Issue aims to gather original research papers, reviews, and commentaries on recent advances in biomarker research in both health and disease. We are particularly interested in new insights into the mechanisms of action underlying physiological and pathological processes and diseases, the discovery of biomarker-associated therapeutic targets, RNA-based therapies associated with biomarkers (including peptide delivery systems), peptide biomarkers (including circulating peptides), and the role of peptides in cell-to-cell communication. The Research Topic seeks to cover innovative research and clinical trends in identifying, characterizing, assessing, and applying molecular biomarkers in different disease conditions.

 

Areas to be covered in this special issue may include, but are not limited to:


1. Role of peptides in immune-mediated cell death in tumor progression and therapy.

2. Pathophysiologic Mechanisms and Potential Biomarkers 
3. Identification and experimental validation of novel molecular, fluid, salivary, tissue, serum, cerebrospinal fluid, spinal fluid, seminal fluid, liquid biopsy biomarkers of different disease conditions such as cancers, neuropathology, neurodegenerative diseases, infectious diseases, pain, psychiatry, cardiovascular
4. Investigation of novel genetic, epigenetic, and biochemical biomarkers

5. Use of biomarkers in human pharmacology

6. Diagnostic and prognostic significance of current and future disease biomarkers
7. Use of combinations of biomarkers and panels of biomarkers for risk prediction, diagnosis, and prognosis of different diseases

 

We welcome original research articles, reviews, mini-reviews, and opinion articles. All submissions will undergo rigorous peer review, and selected articles will be published in the special issue. 


Keywords

neurotransmitters, peptides, immuno-markers, biomarkers, precision medicine

Published Papers


  • Open Access

    REVIEW

    Non-coding RNA as future target for diagnose and treatment of perineural invasion in cancers

    BINGJIE LI, WENBO CAO, JINJING XIAO, YIXIAO CHEN, QIYING WEI, MINGJIN YUE, SAIJUN MO
    BIOCELL, DOI:10.32604/biocell.2024.049160
    (This article belongs to the Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)
    Abstract Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond the primary tumor site, infiltrating distant regions devoid of lymphatic or vascular structures. PNI often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of cancers. Despite its clinical significance, the underlying molecular mechanisms of PNI remain elusive, complicating the development of specific and efficacious diagnostic and therapeutic strategies. In the realm of cancer research, non-coding RNAs (ncRNAs) have attracted considerable… More >

  • Open Access

    ARTICLE

    MAPK9 as a therapeutic target: unveiling ferroptosis in localized prostate cancer progression

    CHENG-GONG LUO, JIAO ZHANG, YUN-ZHAO AN, XUAN LIU, SHUAI-JIE LI, WEI ZHANG, KAI LI, XU ZHAO, DONG-BO YUAN, LING-YUE AN, WEI CHEN, YE TIAN, BIN XU
    BIOCELL, Vol.48, No.5, pp. 771-792, 2024, DOI:10.32604/biocell.2024.048878
    (This article belongs to the Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)
    Abstract Background: Ferroptosis, a lipid peroxidation-mediated programmed cell death, is closely linked to tumor development, including prostate cancer (PCa). Despite established connections between ferroptosis and PCa, a comprehensive investigation is essential for understanding its impact on patient prognosis. Methods: A risk model incorporating four ferroptosis-related genes was developed and validated. Elevated risk scores correlated with an increased likelihood of biochemical recurrence (BCR), diminished immune infiltration, and adverse clinicopathological characteristics. To corroborate these results, we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort (TCGA) and the Gene Expression Synthesis Cohort (GEO). Moreover, we conducted… More >

  • Open Access

    ARTICLE

    Inhibition of SLC26A4 regulated by electroacupuncture suppresses the progression of myocardial ischemia-reperfusion injury

    FEI KONG, QIYUAN TIAN, BINGLIN KUANG, LILI SHANG, XIAOXIAO ZHANG, DONGYANG LI, YING KONG
    BIOCELL, Vol.48, No.4, pp. 665-675, 2024, DOI:10.32604/biocell.2024.046342
    (This article belongs to the Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)
    Abstract Introduction: Myocardial ischemia-reperfusion (IR) injury has received widespread attention due to its damaging effects. Electroacupuncture (EA) pretreatment has preventive effects on myocardial IR injury. SLC26A4 is a Na+ independent anion reverse transporter and has not been reported in myocardial IR injury. Objectives: To find potential genes that may be regulated by EA and explore the role of this gene in myocardial IR injury. Methods: RNA sequencing and bioinformatics analysis were performed to obtain the differentially expressed genes in the myocardial tissue of IR rats with EA pretreatment. Myocardial infarction size was detected by TTC staining. Serum CK,… More >

    Graphic Abstract

    Inhibition of SLC26A4 regulated by electroacupuncture suppresses the progression of myocardial ischemia-reperfusion injury

  • Open Access

    REVIEW

    MicroRNAs modulation in lung cancer: exploring dual mechanisms and clinical prospects

    SHAHID HUSSAIN, HABIB BOKHARI, XINGXING FAN, SHAUKAT IQBAL MALIK, SUNDAS IJAZ, MUHAMMAD ADNAN SHEREEN, AIMAN FATIMA
    BIOCELL, Vol.48, No.3, pp. 403-413, 2024, DOI:10.32604/biocell.2024.044801
    (This article belongs to the Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)
    Abstract The global incidence of lung cancer is marked by a considerably elevated mortality rate. MicroRNAs (miRNAs) exert pivotal influence in the intricate orchestration of gene regulation, and their dysregulation can precipitate dire consequences, notably cancer. Within this context, miRNAs encapsulated in exosomes manifest a diversified impact on the landscape of lung cancer, wherein their actions may either foster angiogenesis, cell proliferation, and metastasis, or counteract these processes. This comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung cancer. Tumor-suppressive miRNAs, such as miR-204, miR-192, miR-30a, miR-34a, miR-34b, miR-203,… More >

  • Open Access

    ARTICLE

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

    SHAN OU, YUN XU, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI, JIE YAO
    BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178
    (This article belongs to the Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)
    Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a… More >

    Graphic Abstract

    Analysis of large datasets for identifying molecular targets in intestinal polyps and metabolic disorders

  • Open Access

    REVIEW

    Crossroads: Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis

    YANG LI, JIAN LIU, YUEDI HU, CHENGZHI CONG, YIMING CHEN, QIAO ZHOU
    BIOCELL, Vol.48, No.1, pp. 9-19, 2024, DOI:10.32604/biocell.2023.045862
    (This article belongs to the Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)
    Abstract Rheumatoid arthritis (RA) is a prevalent autoimmune disease whose main features include chronic synovial inflammation, bone destruction, and joint degeneration. Neutrophils are often considered to be the first responders to inflammation and are a key presence in the inflammatory milieu of RA. Neutrophil extracellular traps (NETs), a meshwork of DNA-histone complexes and proteins released by activated neutrophils, are widely involved in the pathophysiology of autoimmune diseases, especially RA, in addition to playing a key role in the neutrophil innate immune response. NETs have been found to be an important source of citrullinated autoantigen antibodies and More >

    Graphic Abstract

    Crossroads: Pathogenic role and therapeutic targets of neutrophil extracellular traps in rheumatoid arthritis

  • Open Access

    REVIEW

    New insight into the role of exosomes in idiopathic membrane nephropathy

    JIANHONG LIU, KAI HE, HAN WANG, XIAOHONG CHENG
    BIOCELL, Vol.48, No.1, pp. 21-32, 2024, DOI:10.32604/biocell.2023.045631
    (This article belongs to the Special Issue: Advances in Biomarker Research: Unveiling the Pathways to Precision Medicine)
    Abstract Exosomes, nanoscale extracellular vesicles (EVs) derived from the invagination of the endosomal membrane, are secreted by a majority of cell types. As carriers of DNA, mRNA, proteins, and microRNAs, exosomes are implicated in regulating biological activities under physiological and pathological conditions. Kidney-derived exosomes, which vary in origin and function, may either contribute to the pathogenesis of disease or represent a potential therapeutic resource. Membranous nephropathy (MN), an autoimmune kidney disease characterized by glomerular damage, is a predominant cause of nephrotic syndrome. Notably, MN, especially idiopathic membranous nephropathy (IMN), often results in end-stage renal disease (ESRD),… More >

    Graphic Abstract

    New insight into the role of exosomes in idiopathic membrane nephropathy

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