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  • Open Access

    REVIEW

    Therapeutic actions of terpenes in neurodegenerative disorders and their correlations with the regulation and remodeling of the extracellular matrix

    RENATA DA SILVA CARNEIRO1, MATEUS HENRIQUE DE ALMEIDA DA COSTA1, JOSé ZILTON LIMA VERDE SANTOS1, VALDILéIA TEIXEIRA UCHôA2, LUCIANO DA SILVA LOPES3, ANDERSON NOGUEIRA MENDES1,*

    BIOCELL, Vol.49, No.1, pp. 109-125, 2025, DOI:10.32604/biocell.2024.058405 - 24 January 2025

    Abstract Neurodegenerative diseases are a major public health challenge, mainly affecting the elderly population and compromising their cognitive, sensory, and motor functions. Currently, available therapies focus on alleviating symptoms and slowing the progression of these conditions, but they do not yet offer a definitive cure. In this scenario, terpenes emerge as promising natural alternatives due to their neuroprotective properties. These compounds can reduce the formation of protein aggregates, neutralize free radicals, and inhibit pro-inflammatory enzymes, which are crucial factors in the development of neurodegenerative diseases. In addition, terpenes also play an important role in the… More >

  • Open Access

    ARTICLE

    Fractions of a chloroform extract of ajenjo leaves (Artemisia mendozana DC. var. mendozana) inhibit the proliferation, viability and clonogenicity of B16-F0 melanoma cells

    MARÍA ELISA MILLÁN1, MARÍA FERNANDA MARRA1, LEONARDO ANDRÉS SALVARREDI1,2,3, EMILIO FERNANDO LIZARRAGA4,*, LUIS ALBERTO LOPEZ1,*

    BIOCELL, Vol.44, No.3, pp. 293-299, 2020, DOI:10.32604/biocell.2020.012342 - 22 September 2020

    Abstract The ajenjo, Artemisia mendozana DC. var. mendozana (Asteraceae), grows in the Andean foothills of Mendoza and San Juan, Argentina, and is used as a medicinal plant for its antispasmodic and antifungal properties. The aim of this work was to obtain fractions of a chloroform extract of ajenjo leaves and to evaluate the in vitro effects on proliferation, viability and clonogenicity of B16-F0 melanoma cells. Using a silica gel chromatography column, 120 fractions were collected and grouped according to the chromatographic profile in 9 main fractions (F1–F9). Their major compounds identified were: terpenes (F1), terpenes and sesquiterpene lactones (F2–F3), More >

  • Open Access

    ARTICLE

    A revision of Eupatorium (Compositae: Eupatorieae) from Michoacan

    Garcia Sanchez E1,2, CB Ramirez Lopez1,2, REN del Rio Torres2, MM Martinez Pacheco2

    Phyton-International Journal of Experimental Botany, Vol.80, pp. 139-146, 2011, DOI:10.32604/phyton.2011.80.139

    Abstract An important study in species of the genus Eupatorium, that inhabits other parts of the world, was conducted in the search for new molecules with pharmacological activities, thus showing that it is a potential source of novel secondary metabolites. We reviewed the number of Eupatorium species that have been described in the State of Michoacan, and that can be available for harvesting, to make a phytochemical screening. It was found that 69 Eupatorium spp are growing in 69% of the Michoacan territory. Within this group there are ten species used in Mexican traditional medicine. It was evident More >

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