Xuehuan He¹, Stephane Avril², Jia Lu^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 50-52, 2019, DOI:10.32604/mcb.2019.07390

Abstract A Multi-layer Perceptron (MLP) neural network model [1] is developed to predict the strength of ascending thoracic aortic aneurysm (ATAA) tissues using tension-strain data and assess local rupture risk. The data were collected through in vitro inflation tests on ATAA samples from 12 patients who underwent surgical intervention [2]. An inverse stress analysis was performed to compute the wall tension at Gauss points. Some of these Gauss points are at or near sites where the samples eventually ruptured, while others are at locations where the tissue remained intact. A total of 27,648 tension- strain curves, including 26,676 2223 nonrupture and… More >

Stéphane Avril^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 17-18, 2019, DOI:10.32604/mcb.2019.05705

Abstract The fluid mechanics community has been interested for many years in hemodynamics. More recently, significant endeavours of the solid mechanics community have permitted to establish constitutive equations and to achieve stress analyses in arterial lesions (atheromatous plaque in coronary or carotid arteries, aneurysms of the aorta). The mechanical properties of blood vessels have often been characterized ex vivo, but medical imaging, including MRI, now allows non-intrusive identifications in vivo. The spatial heterogeneity of these mechanical properties, even at the macroscopic scale, remains poorly explored despite its undeniable interest in understanding the mechanisms of remodeling and degeneration of the tissue. We… More >

LINGFENG CHEN^1,2,3, ZHIPENG GAO^1,2,3, BAIMEI LIU^1,2,3, YING LV^1,2,3, MEIWEN AN^1,2,3,*, JILING FENG^4,*

BIOCELL, Vol.42, No.1, pp. 25-34, 2018, DOI:10.32604/biocell.2018.06114

Abstract Arterial characterization of healthy descending thoracic aorta (DTA) is indispensable in determining stress distributions across wall thickness and different regions that may be responsible for aorta inhomogeneous dilation, rupture, and dissection when aneurysm occurs. Few studies have shown the inhomogeneity of DTA along the aorta tree considering changes in circumferential direction. The present study aims to clarify the circumferential regional characterization of DTA. Porcine DTA tissues were tested according to region and orientation using uniaxial tension. For axial test, results show that the difference in circumferential direction was mainly in collagen fiber modulus, where the anterior collagen fiber modulus was… More >