Xiaohui Shen, Xia Gao, Hui Li, Yajun Gu, Junguo Wang
Oncology Research, Vol.27, No.1, pp. 73-80, 2019, DOI:10.3727/096504018X15201099883047
Abstract Laryngeal carcinoma is a type of head and neck carcinoma with a high incidence and mortality. Chemotherapy
treatments of human laryngeal carcinoma may fail due to the development of chemoresistance. Tissue inhibitor
of metalloproteinase 3 (TIMP-3) has been shown to be implicated in a number of pathological processes typical
for cancer. The present study aims to investigate the involvement of TIMP-3 in the chemoresistance of laryngeal
carcinoma. We showed that TIMP-3 expression was significantly decreased in chemoresistant laryngeal carcinoma tissues compared with chemosensitivity tissues. Patients with low TIMP-3 expression exhibited poorer
overall survival than those with high TIMP-3 expression. Moreover,… More >
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