Giovanni Matera1, Maria Carla Liberto1, Leo A. B. Joosten2, Maria Vinci1, Angela Quirino1, Maria Concetta Pulicari1, Bart Jan Kullberg2, Jos W. M. Van der Meer2, Mihai G. Netea2, Alfredo Focà1
European Cytokine Network, Vol.19, No.3, pp. 113-118, 2008, DOI:10.1684/ecn.2008.0128
Abstract Bartonella quintana (B. quintana) is a facultative, intracellular bacterium, which causes trench
fever, chronic bacteraemia and bacillary angiomatosis. Little is known about the recognition of B. quintana by the
innate immune system. In this review, we address the impact of Toll-like receptors (TLRs) on the recognition of
B. quintana and the activation of the host defense. When experimental models using human mononuclear cells,
transfected CHO cells, or TLR2-/- and TLR4-/- mice were used, differential effects of TLR2 and TLR4 have been
observed. B. quintana micro-organisms stimulated cytokine production through TLR2-mediated signals, whereas
no role for TLR4 in the recognition of this… More >
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