Ni Kou*1,
Sha Liu*1,
Xiaojie Li*, Wuwei Li*, Weijian Zhong*, Lin Gui*, Songling Chai*, Xiang Ren*,
Risu Na*, Tao Zeng†, Huiying Liu*
Oncology Research, Vol.27, No.2, pp. 173-182, 2019, DOI:10.3727/096504018X15202945197589
Abstract The long noncoding RNA (lncRNA) H19 has been described to participate in the metastasis of various tumors.
Nevertheless, whether H19 promotes or impedes tongue squamous cell carcinoma (TSCC) cell migration and
invasion remains controversial. Here we found that the expression of H19 was elevated in TSCC tissues compared with adjacent normal tissues. Moreover, we demonstrated that the expression of H19 was higher in
metastasized tumors compared with unmetastasized tumors. Consistently, TSCC cells express higher levels of
H19 than human squamous cells. Subsequently, depletion of H19 impaired the migration and invasion abilities of TSCC cells. Mechanistically, we demonstrated that H19 functions… More >
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