SUKHENDU DEY^1,#, SANDIPAN PAL^2,#, APURBA RATAN GHOSH¹, PALAS SAMANTA^3,*

BIOCELL, Vol.47, No.12, pp. 2579-2590, 2023, DOI:10.32604/biocell.2023.031114

Abstract The process of development is intricate and couple-dependent phenomenon. Accordingly, the study of molecular and cellular biology-based developmental toxicology biomarkers increasingly is becoming an important part of risk assessment and management of chemicals for detection of health outcomes and/or biological endpoint like cytotoxicity, cell death, etc. Since, the evolution of developmental toxicology field a number of tools/markers have been developed or addressed to deal with developmental outcomes, which can ultimately be used for the development of adverse outcome pathways (AOPs) of developmental toxicants. As a result, this paper provides an overview of the current state of developmental toxicology biomarkers and… More >

CARLOS ALBERTO-SILVA^1,*, ANA CAROLINA DE ARAUJO¹, RODRIGO SIMãO BONFIM¹, JOYCE MEIRE GILIO²

BIOCELL, Vol.47, No.2, pp. 289-295, 2023, DOI:10.32604/biocell.2023.023787

Abstract Bothrops envenomation is complex and provokes prominent local tissue damage and systemic disturbances, but little is known about their effects on the male reproductive system. After intratesticular injection, the bioactive peptide fraction (Bj-PF) obtained from Bothrops jararaca snake venom changes the structure of different stages of the seminiferous epithelium cycle in adult mice. For the first time, we investigated whether local envenomation of Bj-PF induces toxicological effects on the male reproductive system, particularly on the seminiferous epithelium and Sertoli cells. Male adult mice were treated with 0.24 mg.kg⁻¹ by intramuscular (i.m.) injection for 24 h. The testes samples were collected… More >

KATARINA BARALIć^1,*, KATARINA ŽIVANčEVIć¹, DRAGICA BoŽIĆ¹, DANYEL JENNEN², ALEKSANDRA BUHA DJORDJEVIC¹, EVICA ANTONIJEVIć MILJAKOVIć¹, DANIJELA ĐUKIć-ĆOSIć¹

BIOCELL, Vol.46, No.2, pp. 519-533, 2022, DOI:10.32604/biocell.2022.018271

Abstract This in silico toxicogenomic study aims to explore the relationship between phthalates and bisphenol A (BPA) co-exposure and obesity, as well as its comorbid conditions, in order to construct a possible set of genomic biomarkers. The Comparative Toxicogenomics Database (CTD; http://ctd.mdibl.org) was used as the main data mining tool, along with GeneMania (https://genemania.org), ToppGene Suite (https://toppgene.cchmc.org) and DisGeNET (http://www.disgenet.org). Among the phthalates, bis(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) were chosen as the most frequently curated phthalates in CTD, which also share similar mechanisms of toxicity. DEHP, DBP and BPA interacted with 84, 90 and 194 obesity-related genes/proteins, involved in… More >

PEDRO CARRIQUIRIBORDE, ALICIA RONCO

BIOCELL, Vol.30, Suppl.S, pp. 97-109, 2006

Abstract This article has no abstract. More >

Gregory Reimonn¹, Taofeng Lu¹, Neeti Gandhi², Wan-Ting Chen^1,*

Journal of Renewable Materials, Vol.7, No.12, pp. 1251-1268, 2019, DOI:10.32604/jrm.2019.08055

Abstract Microplastic pollution represents a side-effect stemming from a global plastic waste mismanagement problem and includes degraded particles or mass produced plastic particles less than 5 mm in largest dimension. The small nature of microplastics gives this area of pollution different environmental concerns than general plastic waste in the environment. The biological toxicity of particles, their internal components, and their surface level changes all present opportunities for these particles to adversely affect the environment around them. Thus, it is necessary to review the current literature surrounding this topic and identify areas where the study of microplastic can be pushed forward. Here… More >