Yong Wang*, Rui-Zhi Jia*, Shu Diao*, Jun He†, Li Jia†
Oncology Research, Vol.28, No.2, pp. 203-212, 2020, DOI:10.3727/096504019X15761480623959
Abstract Despite the considerable knowledge on the involvement of microRNA-101 (miR-101) in the evolution of oral
squamous cell carcinoma (OSCC), the underlying mechanisms remain obscure. In this study, miR-101 expression
was markedly downregulated in the OSCC cell lines and tissues. Cell counting kit-8 (CCK-8), ethynyl deoxyuridine (EdU), and colony formation assays showed that miR-101 inhibited the proliferation of OSCC cells. Flow
cytometry and caspase 3 activity assays indicated that miR-101 induced OSCC cell apoptosis. Transwell assays
demonstrated that this miRNA also repressed OSCC cell migration and invasion. Moreover, tube formation
assay showed that miR-101 abated the proangiogenesis of OSCC cells. Dual-luciferase… More >
Login
Register
