Jie Wei*†1,
Yuanliang Yan*†1,
Xi Chen*†, Long Qian*†, Shuangshuang Zeng*†, Zhi Li‡,
Shuang Dai*†, Zhicheng Gong*†,Zhijie Xu§
Oncology Research, Vol.27, No.7, pp. 849-858, 2019, DOI:10.3727/096504018X15447833065047
Abstract Over the past decade, natural compounds have been proven to be effective against many human diseases,
including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii
Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). Here we mainly
focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC,
such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF- B activation, suppression
of miRNA expression, etc. In addition, the effect… More >
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