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    The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer

    Jie Wei*†1, Yuanliang Yan*†1, Xi Chen*†, Long Qian*†, Shuangshuang Zeng*†, Zhi Li, Shuang Dai*†, Zhicheng Gong*†,Zhijie Xu§

    Oncology Research, Vol.27, No.7, pp. 849-858, 2019, DOI:10.3727/096504018X15447833065047

    Abstract Over the past decade, natural compounds have been proven to be effective against many human diseases, including cancers. Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). Here we mainly focused on the key molecular signaling pathways that lead to the inhibitory effects of TPL on human NSCLC, such as mitogen-activated protein kinases (MAPKs) modulation, inhibition of NF- B activation, suppression of miRNA expression, etc. In addition, the effect… More >

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